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Analysis of Stimuli Discrimination in Indian Patients with Chronic Schizophrenia

  • Jaskirat Singh
  • Sukhwinder Singh
  • Savita Gupta
  • Bir Singh Chavan
Chapter
Part of the Advances in Intelligent Systems and Computing book series (AISC, volume 897)

Abstract

Event-Related Potentials (ERPs) components are widely studied to understand brain response associated with cognitive processes in terms of amplitude, latency, and brain topography. Schizophrenia is a psychiatric illness which is characterized by reduced amplitude and increased latency of P300 ERP component. In this work, we have analyzed the attributes of P300 component involved during discrimination of visual stimuli (frequent, infrequent, and rare) at midline frontal and parietal sites in 14 schizophrenic patients who were receiving remediation in psychiatric setup for a long time. The key findings include increase in P300 amplitude when infrequent and rare stimuli were presented which reflected better contribution of attentional resources toward discrimination of stimuli. The P300 latency was found to be increased at same measurement sites for standards and rares for which the responses have to be ignored. The latencies were reduced in the case of infrequent stimuli (targets) which reflected better speed of cognitive processes involved during the identification of the stimuli.

Keywords

Schizophrenia Event-Related Potentials P300 Amplitude Latency 

References

  1. 1.
    Jutzeler, C.R., Mcmullen, M.E., Featherstone, R.F., Tatardleitman, V.M., Gandal, M.J., Carlson, G.C., Siegel, S.J.: Electrophysiological Deficits in Schizophrenia: Models and Mechanisms in Psychiatric Disorders Trends and Developments. IntechOpen (2011). ISBN 978-953-307-745-1Google Scholar
  2. 2.
    Oribe, N., Yoji, H., Kanba, S., Del Re, E., Seidman, L., Mesholam-Gately, R., Goldstein, J.M., et al.: Progressive reduction of visual P300 amplitude in patients with first-episode schizophrenia: an ERP study. Schizophr. Bull. 41(2), 460–470 (2014)Google Scholar
  3. 3.
    Polich, J.: Updating P300: an integrative theory of P3a and P3b. Clin. Neurophysiol. 118(10), 2128–2148 (2007)CrossRefGoogle Scholar
  4. 4.
    Ford, J.M., Mathalon, D.H., Marsh, L., Faustman, W.O., Harris, D., Hoff, A.L., Beal, M., Pfefferbaum, A.: P300 amplitude is related to clinical state in severely and moderately ill patients with schizophrenia. Biol. Psychiatry 46(1), 94–101 (1999)CrossRefGoogle Scholar
  5. 5.
    Rao, K.J., Ananthnarayanan, C.V., Gangadhar, B.N., Janakiramaiah, N.: Smaller auditory P300 amplitude in schizophrenics in remission. Neuropsychobiology 32(3), 171–174 (1995)CrossRefGoogle Scholar
  6. 6.
    Turetsky, B.I., Cannon, T.D., Gur, R.E.: P300 subcomponent abnormalities in schizophrenia: III. Deficits in unaffected siblings of schizophrenic probands. Biol. Psychiatry 47(5), 380–390 (2000)CrossRefGoogle Scholar
  7. 7.
    Faux, S.F., McCarley, R.W., Nestor, P.G., Shenton, M.E., Pollak, S.D., Penhune,V., Mondrow, E., Marcy, B., Peterson, A., Horvath, T., Davis, K.L.: P300 topographic asymmetries are present in unmedicated schizophrenics. Electroencephalogr. Clin. Neurophysiol./Evoked Potentials Sect. 88(1), 32–41 (1993)Google Scholar
  8. 8.
    Sahoo, S., Malhotra, S., Basu, D., Modi, M.: Auditory P300 event related potentials in acute and transient psychosis—comparison with schizophrenia. Asian J. Psychiatry 23, 8–16 (2016)CrossRefGoogle Scholar
  9. 9.
    McCathern, A.: Emitted P3a and P3b in chronic schizophrenia and in first episode schizophrenia. Doctoral dissertation, University of Pittsburgh. http://dscholarship.pitt.edu/31431/ (2017)
  10. 10.
    Kim, M., Lee, T.H., Kim, J.H., Hong, H., Lee, T.Y., Lee, Y., Salisbury, D.F., Kwon, J.S.: Decomposing P300 into correlates of genetic risk and current symptoms in schizophrenia: an inter-trial variability analysis. Schizophr. Res. (2017)Google Scholar
  11. 11.
    Vafaii, P., Mazhari, S., Pourrahimi, A.M., Nakhaee, N.: Hemispheric differences for visual P3 amplitude in patients with schizophrenia. Neuropsychiatry (London) 6(6), 309 (2016)Google Scholar
  12. 12.
    Luck, S.J.: An Introduction to the Event-Related Potential Technique (Cognitive Neuroscience). The MIT Press (2005)Google Scholar
  13. 13.
    Jeek, P.: Database of EEG/ERP experiments: technical report no. DCSE/TR-201004. https://dspace5.zcu.cz/handle/11025/21566 (2010)
  14. 14.
    Acharya, J.N., Hani, A.J., Thirumala, P., Tsuchida, T.N.: American clinical neurophysiology society guideline 3: a proposal for standard montages to be used in clinical EEG. Neurodiagn. J. 56(4), 253–260 (2016)CrossRefGoogle Scholar
  15. 15.
    Delorme, A., Palmer, J., Onton, J., Oostenveld, R., Makeig, S.: Independent EEG sources are dipolar. PLoS ONE 7(2), e30135 (2012)CrossRefGoogle Scholar
  16. 16.
    Molina, G.N.G.: Direct brain-computer communication through scalp recorded EEG signals. École Polytechnique Fédérale de Lausanne (2004)Google Scholar
  17. 17.
    Chaumon, M., Bishop, D.V., Busch, N.A.: A practical guide to the selection of independent components of the electroencephalogram for artifact correction. J. Neurosci. Methods 250, 47–63 (2015)CrossRefGoogle Scholar
  18. 18.
    Mognon, A., Jovicich, J., Bruzzone, L., Buiatti, M.: ADJUST: An automatic EEG artifact detector based on the joint use of spatial and temporal features. Psychophysiology 48(2), 229–240 (2011)CrossRefGoogle Scholar
  19. 19.
    Delorme, A., Makeig, S.: EEGLAB: an open source toolbox for analysis of single-trial EEG dynamics including independent component analysis. J. Neurosci. Methods 134(1), 9–21 (2004)CrossRefGoogle Scholar
  20. 20.
    Lopez-Calderon, J., Luck, S.J.: ERPLAB: an opensource toolbox for the analysis of event-related potentials. Front. Hum. Neurosci. 8, 213 (2014)CrossRefGoogle Scholar
  21. 21.
    Picton, T.W.: The P300 wave of the human event related potential. J. Clin. Neurophysiol. 9, 456–456 (1992)Google Scholar

Copyright information

© Springer Nature Singapore Pte Ltd. 2019

Authors and Affiliations

  • Jaskirat Singh
    • 1
  • Sukhwinder Singh
    • 1
  • Savita Gupta
    • 1
  • Bir Singh Chavan
    • 2
  1. 1.University Institute of Engineering and Technology, Panjab UniversityChandigarhIndia
  2. 2.Department of PsychiatryGovernment Medical College and HospitalChandigarhIndia

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