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Benzothiophenes as Potent Analgesics Against Neuropathic Pain

  • Saurabh Yadav
  • Vishnu Kumar Dwivedi
  • Sarika Gupta
  • Avadhesha SuroliaEmail author
Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1112)

Abstract

Neuropathic pain arises because of neuronal injury. Unlike inflammatory pain which can be managed by classical nonsteroid anti-inflammatory drugs (NSAIDs), neuropathic pain is difficult to treat. The classical NSAIDs work through inhibition of cyclooxygenase 2 (COX2) enzyme. However, COX2 inhibitors are insufficient to treat neuropathic pain. Hence, it becomes important to explore for novel molecules acting through cell surface molecules like ion channels, for the treatment of neuropathic pain. We investigated multiple bromobenzothiophene carboxamides for their efficacy against neuropathic pain. Interestingly, AS6 was found to be very effective in treating neuropathic pain through inhibition of Kv4.3 ion channel. AS6 also reduced the COX2 overexpression associated with neuropathic pain. These results as well as results from our previous study indicate that AS6 can be a potent antinociceptive agent against both inflammatory and neuropathic pain.

Keywords

Neuropathic pain NSAIDs COX2 Bromobenzothiophenes Inflammation 

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Copyright information

© Springer Nature Singapore Pte Ltd. 2018

Authors and Affiliations

  • Saurabh Yadav
    • 1
  • Vishnu Kumar Dwivedi
    • 2
  • Sarika Gupta
    • 2
  • Avadhesha Surolia
    • 1
    Email author
  1. 1.Molecular Biophysics UnitIndian Institute of ScienceBangaloreIndia
  2. 2.National Institute of Immunology, Aruna Asaf Ali MargJawaharlal Nehru UniversityNew DelhiIndia

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