Chemotherapy for Metastatic Colorectal Cancer

  • Takeshi YamadaEmail author
  • Michihiro Koizumi
  • Seiichi Shinji
  • Akihisa Matsuda
  • Yasuyuki Yokoyama
  • Goro Takahashi
  • Takuma Iwai
  • Keisuke Hara
  • Masahiro Hotta
  • Kohki Takeda
  • Kohji Ueda
  • Hiroshi Yoshida


The overall survival of patients with unresectable metastatic colorectal cancer (mCRC) has increased from approximately 1 year during the era of fluoropyrimidine monotherapy to >30 months with the combination of cytotoxic agents and molecular-targeted agents. Here, we review the current landscape of chemotherapy for mCRC. The recent establishment of late-line chemotherapy, including regorafenib and TAS-102, and development of biomarker analysis have attracted much attention. Maintenance and rechallenge are relatively new concepts. The former has been developed for less-invasive treatment and the latter because performance status of patients with mCRC is good beyond standard second-line chemotherapy.


Colorectal cancer Chemotherapy EGFR VEGF Rechallenge 


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Copyright information

© Springer Nature Singapore Pte Ltd. 2019

Authors and Affiliations

  • Takeshi Yamada
    • 1
    Email author
  • Michihiro Koizumi
    • 1
  • Seiichi Shinji
    • 1
  • Akihisa Matsuda
    • 1
  • Yasuyuki Yokoyama
    • 1
  • Goro Takahashi
    • 1
  • Takuma Iwai
    • 1
  • Keisuke Hara
    • 1
  • Masahiro Hotta
    • 1
  • Kohki Takeda
    • 1
  • Kohji Ueda
    • 1
  • Hiroshi Yoshida
    • 1
  1. 1.Department of Gastrointestinal and Hepato-Biliary-Pancreatic SurgeryNippon Medical SchoolTokyoJapan

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