Advertisement

Hepatitis C Virus Infection

  • Etsuko Iio
  • Yasuhito TanakaEmail author
Chapter

Abstract

The estimated 170 million carriers worldwide persistently infected with hepatitis C virus (HCV) make a global health problem affecting a significant proportion of the world’s population. HCV infection poses a significant risk for progressive hepatic fibrosis, subsequent liver cirrhosis (LC) and hepatocellular carcinoma (HCC). It is estimated that 28% of cases of LC and 26% of cases of HCC are attributable to HCV.

Interferon (IFN)-free oral regimens combining direct-acting antiviral agents (DAAs) available from 2014 have achieved remarkably high rates of HCV eradication. However, there is still a risk of HCC after eradicating HCV.

Keywords

HCV DAA IFN HCC SVR 

References

  1. Akuta N et al (2010) Amino acid substitution in hepatitis C virus core region and genetic variation near the interleukin 28B gene predict viral response to telaprevir with peginterferon and ribavirin. Hepatology 52:421–429CrossRefGoogle Scholar
  2. Ge D et al (2009) Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance. Nature 461:399–401CrossRefGoogle Scholar
  3. Matsuura K et al (2017) Genome-wide association study identifies TLL1 variant associated with development of hepatocellular carcinoma after eradication of hepatitis C virus infection. Gastroenterology 152(6):1383–1394CrossRefGoogle Scholar
  4. Okamoto T et al (2006) Hepatitis C virus RNA replication is regulated by FKBP8 and Hsp90. EMBO J 25:5015–5025CrossRefGoogle Scholar
  5. Saito I et al (1990) Hepatitis C virus infection is associated with the development of hepatocellular carcinoma. Proc Natl Acad Sci U S A 87:6547–6549CrossRefGoogle Scholar
  6. Simmonds P et al (2005) Consensus proposals for a unified system of nomenclature of hepatitis C virus genotypes. Hepatology 42:962–973CrossRefGoogle Scholar
  7. Tanaka Y et al (2009) Genome-wide association of IL28B with response to pegylated interferon-alpha and ribavirin therapy for chronic hepatitis C. Nat Genet 41:1105–1109CrossRefGoogle Scholar
  8. Thomas DL et al (2009) Genetic variation in IL28B and spontaneous clearance of hepatitis C virus. Nature 461:798–801CrossRefGoogle Scholar

Copyright information

© Springer Nature Singapore Pte Ltd. 2019

Authors and Affiliations

  1. 1.Department of Virology, Liver UnitNagoya City University Graduate School of Medical SciencesNagoyaJapan

Personalised recommendations