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Hemophagocytic Lymphohistiocytosis

  • Kyung-Nam KohEmail author
Chapter

Abstract

A previously healthy 11-month-old girl was transferred to the emergency room (ER) with a 7-day history of high fever and progressive lethargy. Her parents reported that she had developed mild cough and rhinorrhea 1 week before presentation. These symptoms were followed by severe illness with high fever, distended abdomen, skin rash, and poor oral intake. She was empirically started on broad-spectrum antibiotics at the referring hospital before transfer.

Keywords

Hemophagocytic lymphohistiocytosis (HLH) Perforin/granzyme pathway Familial hemophagocytic lymphohistiocytosis (FHL) Secondary hemophagocytic lymphohistiocytosis (secondary HLH) Hyperinflammation 

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Copyright information

© Springer Nature Singapore Pte Ltd. 2019

Authors and Affiliations

  1. 1.Division of Pediatric Hematology/Oncology, Department of Pediatrics, Asan Medical Center Children’s HospitalUniversity of Ulsan College of MedicineSeoulSouth Korea

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