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Systemic Diseases with an Increased Risk of Oral Squamous Cell Carcinoma

  • Martina K. ShephardEmail author
  • Esther A. Hullah
Chapter
Part of the Head and Neck Cancer Clinics book series (HNCC)

Abstract

There is a growing awareness of the important relationships between systemic inflammatory diseases, infections, genetic disorders, medical therapies and cancer risk. A number of systemic disorders have been associated with an increased risk of head and neck squamous cell carcinoma. These include autoimmune conditions, genetic syndromes, infections, iatrogenic causes such as haematopoietic stem cell transplantation and graft-versus-host disease and rare associations including novel drugs. This chapter will discuss conditions which confer an increased risk of head and neck squamous cell carcinoma, as well as review the evidence for diseases which have been historically associated with oral cancer.

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Copyright information

© Peter A. Brennan, Tom Aldridge, Raghav C. Dwivedi, Rehan Kazi 2019

Authors and Affiliations

  1. 1.Oral Medicine, Eastman Dental HospitalUniversity College London Hospitals NHS TrustLondonUK
  2. 2.Oral MedicineGuy’s and St Thomas’ NHS Foundation TrustLondonUK

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