Oral Lichen Planus and the Lichenoid Group of Diseases

  • Felipe Paiva Fonseca
  • Peter A. Brennan
  • Ricardo Santiago Gomez
  • Hélder Antônio Rebelo Pontes
  • Eduardo Rodrigues Fregnani
  • Márcio Ajudarte Lopes
  • Pablo Agustin Vargas
Part of the Head and Neck Cancer Clinics book series (HNCC)


According to available articles that investigated patients affected by OLP, it seems that only a very small rate of malignant transformation may occur in these chronic autoimmune disorders. However, the difficult reproducibility of lichen planus diagnosis, the short and irregular follow-up periods, the simultaneous use of risk factors for oral cancer, and the lack of a well-controlled prospective clinical study are some limitations that impair that any strong conclusion on the real potential for carcinomatous change of OLP is obtained. Moreover, these methodological limitations also avoid that possible predictive factors for OSCC development are found. Therefore, the main objective of future studies must be to obtain large samples of cases strictly selected based on current clinical and morphological criteria for diagnosing OLP, so that more reliable data can be provided and the controversial discussion on malignant transformation of OLP that already takes over a century can be better clarified. New biomarkers may also improve the diagnosis of OLP and better differentiate this lesion from its main differential diagnoses.


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Copyright information

© Peter A. Brennan, Tom Aldridge, Raghav C. Dwivedi, Rehan Kazi 2019

Authors and Affiliations

  • Felipe Paiva Fonseca
    • 1
  • Peter A. Brennan
    • 2
  • Ricardo Santiago Gomez
    • 1
  • Hélder Antônio Rebelo Pontes
    • 3
  • Eduardo Rodrigues Fregnani
    • 4
  • Márcio Ajudarte Lopes
    • 5
  • Pablo Agustin Vargas
    • 5
  1. 1.Department of Oral Surgery and Pathology, School of DentistryUniversidade Federal de Minas GeraisBelo HorizonteBrazil
  2. 2.Department of Oral & Maxillofacial SurgeryQueen Alexandra HospitalPortsmouthUK
  3. 3.Service of Oral Pathology, João de Barros Barreto University HospitalFederal University of ParáBelémBrazil
  4. 4.Service of Oral MedicineSírio-Libanês HospitalSão PauloBrazil
  5. 5.Department of Oral Diagnosis (Pathology and Semiology), Piracicaba Dental SchoolUniversity of CampinasPiracicabaBrazil

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