The Role of Sleep in Homeostatic Regulation of Ionic Balances and Its Implication in Cognitive Functions

  • Fayaz Ahmad Mir
  • Sushil K. Jha
  • Vibha M. Jha


Several studies have suggested that physiological sleep is an indispensable part of the system. It is, however, not known what sleep does to our brain and body. Sleep helps to modulate transcription and translational processes, synaptic neurotransmission, metabolic processes, detoxification, restitution, proliferation, thermoregulation and neuro-immuno-endocrine information, stress reactions, emotional fluctuations, growth, timekeeping, and strategy for survival. In addition, evidences suggest that sleep could be involved in the maintenance of inter- and intracellular microenvironments. Sleep may modulate the homeostatic regulation of (a) acid-base balance, (b) biological buffer system, and (c) ionic/electrolytic balances. We have proposed earlier that one of the essential functions of REM sleep could be to maintain normal bodily CO2 level during sleep. The elevated bodily CO2 level during prolonged vigilant states can adversely alter the cellular ionic milieu. Therefore, it is essential that the level of CO2 must remain within physiological limits, and sleep seems to play an essential role in the maintenance of physiological CO2 level. Furthermore, sleep may also be playing an essential role in maintaining homeostatic balance of several ions such as iron, calcium, potassium, sodium, zinc, magnesium, etc. In this chapter, we discuss the role of sleep in the maintenance of ionic and acid-base balances. We have also addressed how the chronic and acute sleep loss can cause ionic imbalances leading to cellular distress. Further, we have attempted to highlight the influence of ionic homeostatic dysregulation on cognitive performances.


Acid-base balance Energy homeostasis Learning and memory Respiratory acidosis NREM sleep REM sleep and sleep deprivation 



Funding to SKJ from DBT, DST, DST-PURSE, UGC-Resource Networking, UGC-SAP, and UPOE-II is highly acknowledged.


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Copyright information

© Springer Nature Singapore Pte Ltd. 2019

Authors and Affiliations

  • Fayaz Ahmad Mir
    • 1
  • Sushil K. Jha
    • 2
  • Vibha M. Jha
    • 2
  1. 1.School of Life ScienceJawaharlal Nehru UniversityNew DelhiIndia
  2. 2.Sleep Research Laboratory, School of Life SciencesJawaharlal Nehru UniversityNew DelhiIndia

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