Future Treatment and Other New Biologics for Asthma

  • Hiroshi OhnishiEmail author
  • Akihito Yokoyama
Part of the Respiratory Disease Series: Diagnostic Tools and Disease Managements book series (RDSDTDM)


Various cytokines and their receptors implicated in asthma pathophysiology are new targets for future treatments for severe asthma. There are several asthma endotypes that are characterized by the presence of (1) immunoglobulin E (IgE)-mediated inflammation, (2) type 2 inflammation (T2)-high, and (3) T2-low. Endotype-based approaches are new therapeutic strategies for severe asthma. In some countries, monoclonal antibodies (mAbs) that block IgE or interleukin (IL)-5 signaling are being used to treat severe allergic asthma and severe eosinophilic asthma, respectively. Neutralizing mAbs that target the IL-4/IL-13 signaling pathway and thymic stromal lymphopoietin (TSLP) were investigated in several clinical trials involving patients with severe asthma. Drugs generated from these mAbs, such as dupilumab and tezepelumab, may be promising treatments for severe asthma patients. An antagonist of the chemoattractant receptor-homologous molecule on Th2 cells (CRTh2) is another promising drug for the treatment of asthma. Macrolides are also effective for reducing asthma exacerbation in patients with severe asthma. Together, these therapies hold promise for more effective management of asthma.


Biologic Chemoattractant receptor-homologous molecule on Th2 cells (CRTh2) IL-4 IL-5 IL-13 Macrolide Severe asthma Thymic stromal lymphopoietin (TSLP) 



Asthma control questionnaire


Antibody-dependent cell cytotoxicity


Asthma quality of life questionnaire




Chemoattractant receptor-homologous molecule on Th2 cells


Eosinophilic granulomatosis with polyangiitis


Food and Drug Administration


Fraction of exhaled nitric oxide


Forced expiratory volume in 1 second


Inhaled corticosteroids


Immunoglobulin E




Group 2 innate lymphoid cells


Long-acting β2 agonist


Long-acting muscarinic antagonist


Monoclonal antibody


Oral corticosteroids


Quality of life


Type 2 helper T


Thymic stromal lymphopoietin


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© Springer Nature Singapore Pte Ltd. 2019

Authors and Affiliations

  1. 1.Department of Hematology and Respiratory Medicine, Kochi Medical SchoolKochi UniversityNankokuJapan

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