Aspirin-Exacerbated Respiratory Disease (AERD)

  • Masami TaniguchiEmail author
  • Chihiro Mitsui
  • Hiroaki Hayashi
Part of the Respiratory Disease Series: Diagnostic Tools and Disease Managements book series (RDSDTDM)


The characteristics in AERD are severe asthma, eosinophilic rhinosinusitis, and cysteinyl leukotriene (CysLT) overproduction. The interaction between platelets and granulocytes leads to the CysLT overproduction and severe eosinophilic inflammation. The ongoing activation of mast cells is key pathogenesis in not only stable AERD but exacerbated AERD by aspirin. Omalizumab is an effective option for AERD via suppression of mast cell activation.


AERD Leukotriene Severe asthma Omalizumab Eosinophilic sinusitis 


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Copyright information

© Springer Nature Singapore Pte Ltd. 2019

Authors and Affiliations

  • Masami Taniguchi
    • 1
    Email author
  • Chihiro Mitsui
    • 1
  • Hiroaki Hayashi
    • 1
  1. 1.Clinical Research CenterSagamihara National HospitalSagamiharaJapan

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