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Past and Current Arsenic Poisonings

  • Hiroshi YamauchiEmail author
  • Ayako Takata
Chapter
Part of the Current Topics in Environmental Health and Preventive Medicine book series (CTEHPM)

Abstract

The health issues arising from the exposure to inorganic arsenic (iAs), an increasingly important problem in Asia, are remarkable because the source of the iAs is the natural environment and the number of people affected is in the order of tens of millions. In many cases 20–30 years have passed since the onset of exposure to high-level iAs, which raises concern about the imminent occurrence of excessive cancers related to this exposure, as this is the typical time frame for chemically induced cancer in humans. Studies conducted in Chile and Argentina, where oral exposure to iAs has a longer history than in Asia, have revealed a causal relationship between iAs and lung and bladder cancers. Furthermore, multiple studies have presented evidence that early life iAs exposures can influence the next generation by induction of tumors and brain dysfunctions. Follow-up surveys on subacute arsenic poisoning in infants that occurred about 50 years ago in Japan (approximately 12,000 victims, including 130 deaths) confirmed the manifestations of growth inhibition and central nervous system disorders. These findings over the last century provide essential information for the planning and implementation of future studies. Because it is necessary to intensify research on the influences of arsenic compounds on the next generation and on its impact on brain function, promotion of future studies involving collaboration across the fields of medicine, neurology, environmentology, pharmacy, nutritional science, and engineering is required.

Keywords

Historical arsenic poisonings Chronic arsenic poisoning Inorganic arsenic contamination of drinking water Inorganic arsenic contamination of food Medicinal arsenicals 

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Copyright information

© Springer Nature Singapore Pte Ltd. 2019

Authors and Affiliations

  1. 1.Department of Preventive MedicineSt. Marianna University School of MedicineKawasakiJapan

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