Future Directions in Vascularized Composite Allotransplantation Field

  • Yur-Ren Kuo
Part of the Head and Neck Cancer Clinics book series (HNCC)


Vascularized composite allotransplantation (VCA) was proposed as a feasible treatment option for complex reconstructive procedures, which includes tumor ablation surgeries, traumatic injuries, and burn-induced extensive tissue loss. Composite tissue allotransplantation is composed of heterogeneous tissues of diverse antigenicity, including the skin, fat, lymph nodes, muscle, nerves, ligaments, cartilage, bone, and bone marrow. Therefore, VCA is believed to generate a higher response in comparison with transplant of solid organs (e.g., the heart, lung, kidney, liver, etc.). VCA serves to solve functional loss and improves the quality of life comparing with solid organ transplantation (SOT), which is lifesaving in most circumstances.


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Copyright information

© The Author(s) 2019

Authors and Affiliations

  • Yur-Ren Kuo
    • 1
    • 2
    • 3
  1. 1.Division of Plastic Surgery, Department of SurgeryKaohsiung Medical University HospitalKaohsiungTaiwan
  2. 2.Faculty of Medicine, College of MedicineKaohsiung Medical UniversityKaohsiungTaiwan
  3. 3.Department of Biological SciencesNational Sun Yat-sen UniversityKaohsiung CityTaiwan

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