Quorum Sensing in Streptococcus pyogenes and Their Role in Establishment of Disease

  • Parul Sahu
  • Pallaval Veera Bramhachari


The social behaviour of bacteria for the fulfilment of different physiological activities is defined as Quorum Sensing (QS). This ranges from conjugation, symbiosis, virulence, antibiotic production, sporulation and biofilm formation. Streptococcus pyogenes which is also named as group A streptococcus (GAS) is a Gram-positive bacteria, is reported to cause diseases strictly in human. The different QS mechanisms in GAS (group A streptococcus) reported till date include Rgg-SHP quorum sensing pathway, SilC (streptococcal invasion locus) quorum-sensing pathway, Lantibiotic regulatory systems, LuxS and AI-2. The proteins of Rgg family are conserved transcription factors, which is modulated by short peptides, thus involve in the biofilm formation and virulence of bacteria. The SilC mechanism involved in the invasive tissue disease and also in the biofilm formation, Lantibiotic regulatory systems aids bacteria in adopting different immune evasion strategies and thus allow them to persist in the harsh hostile environment. Lastly, LuxS and AI-2 are the common mechanisms in all the different bacterial species including streptococcus for the virulence, motility and bio-film formation. The current chapter focuses on the detail mechanism of all the four different pathways along with the role of Quorum Sensing for the establishment of disease in the host, the immune evasion strategies of bacteria using Quorum sensing (QS) and future clinical perspective with possible applications. This may help to increase our vision towards putative vaccine targets by exploiting the mechanisms involved in Quorum Sensing.


Quorum sensing Streptococcus pyogenes (GAS) Virulence Immune evasion 


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Copyright information

© Springer Nature Singapore Pte Ltd. 2018

Authors and Affiliations

  • Parul Sahu
    • 1
  • Pallaval Veera Bramhachari
    • 2
  1. 1.Product Development Cell-1National Institute of ImmunologyNew DelhiIndia
  2. 2.Department of BiotechnologyKrishna UniversityMachilipatnamIndia

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