Quorum Sensing in Helicobacter pylori: Role of Biofilm and Its Implications for Antibiotic Resistance and Immune Evasion

  • Surekha Challa
  • Nageswara Rao Reddy Neelapu


Helicobacter pylori colonizes the host inducing gastritis, gastric ulcer and cancer. Successful infection in harsh environment requires a special mechanism to colonize the epithelial lining of the host stomach. Antibiotic resistance reports on H. pylori have driven the research to identify the factors contributing to antibiotic resistance. Many reports were there on the communities of microorganisms growing on different surfaces. Such communities of microorganisms growing on the surfaces like gastric mucosa are known as biofilms. The formation of biofilms by H. pylori on the surfaces of gastric mucosa can be one of the reasons for antibiotic resistance and successful infection in the harsh acidic environment. Several reports were also there on formation of biofilm and quorum sensing in H. pylori. The present chapter reviews formation of biofilm, quorum sensing and the advantages of H. pylori biofilm which are responsible for successful colonization.


Helicobacter pylori Biofilm Immune evasion Antibiotic resistance 



CS and NNR are grateful to GITAM (Deemed to be University) for providing necessary facilities to carry out the research work and for extending constant support.

Authors Contribution

CS and NNR initiated the review, participated in writing and revised the manuscript.

Conflict of Interest Statement

The authors declare that there is no potential conflict of interest.


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Copyright information

© Springer Nature Singapore Pte Ltd. 2018

Authors and Affiliations

  • Surekha Challa
    • 1
  • Nageswara Rao Reddy Neelapu
    • 1
  1. 1.Department of Biochemistry and BioinformaticsGITAM Institute of Science, Gandhi Institute of Technology and Management (GITAM)VisakhapatnamIndia

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