Perspective of Quorum Sensing Mechanism in Candida albicans
- 453 Downloads
Candida albicans a polymorphic fungus can cause wide range of disease in humans, its potential to transform between yeast to hypha form and biofilm formation is associated with its virulence. The regulated expression of virulence genes plays a critical role during pathogenesis and immune evasion. The synchronized expression of genes in accordance with the population density is define as Quorum sensing (QS).There are enormous information about prokaryotic QS but the eukaryotic QS was concealed till the discovery of farnesol in Candida albicans. Farnesol is a sesquiterpine alcohol produce endogenously in plants, animals and fungi. It inhibits the initiation of hyphal formation. Apart from farnesol other quorum sensing molecule (QSM) in fungal kingdom includes aromatic amino acid derived alcohols like tyrosol, tryptophol and phenylethanol. This chapter emphasizes more on the various types of mechanisms involved in the fungal Quorum sensing, elaborating their physiological effects and quorum sensing involved during the host-pathogen interactions. Understanding of Quorum sensing mechanisms in Candida albicans may open the door of various therapeutic possibilities.
KeywordsCandida albicans Quorum sensing mechanisms Farnesol
I gratefully acknowledge the University Grant Commission, Government of India for awarding Junior and Senior Research Fellowship.
Conflict of Interest
Authors have no conflict of interest.
- 10.Derengowski, L. S., De-Souza-Silva, C., Braz, S. V., et al. (2009). Antimicrobial effect of farnesol, a Candida albicans quorum sensing molecule, on Paracoccidioides brasiliensis growth and morphogenesis. Annals of Clinical Microbiology and Antimicrobials, 8, 13 [PubMed: 19402910].CrossRefGoogle Scholar
- 36.Zordan, R., & Cormack, B. (2012). Adhesins on Opportunistic Fungal Pathogens. In R. A. Calderone & C. J. Clancy (Eds.), Candida and Candidiasis (pp. 243–259). Washington, DC: ASM Press.Google Scholar