Drug-Induced Nephrotoxicity

  • Deepa H. Chand
  • Meenal Patwardhan


A 6-year-old female with a history of spina bifida is admitted for presumed acute pyelonephritis with fevers, vomiting, and abdominal pain. Her urine culture and sensitivity results are pending. She has a past medical history significant for a ventriculoperitoneal (VP) shunt, gastrostomy tube, and neurogenic bladder. She has been admitted several times in the past for pyelonephritis with bacteremia. Her baseline renal function equates to an estimated glomerular filtration rate (eGFR) of approximately 60 mL/min/1.73 m2. You are consulted by the hospitalist to provide input regarding the choice of antibiotic and dosage to be prescribed.

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Copyright information

© Springer Nature Singapore Pte Ltd. 2019

Authors and Affiliations

  • Deepa H. Chand
    • 1
  • Meenal Patwardhan
    • 2
  1. 1.AbbvieUniversity of Illinois College of MedicineChicagoUSA
  2. 2.Research and DevelopmentAbbvie, Inc.North ChicagoUSA

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