Acute Tubulointerstitial Nephritis

  • Uri S. AlonEmail author


Tubulointerstitial nephritis, indicating an inflammatory process in the tubulointerstitial compartment, is traditionally divided between acute and chronic diseases. In the pediatric intensive care unit, more commonly seen is a child with acute illness, who developed acute kidney injury. The etiologies of acute tubulointerstitial nephritis are divided between medications, infectious, immune-mediated, and others. Besides the increase in serum creatinine concentration, the clinical and laboratory findings are not specific, and the definitive diagnosis can be established only by kidney biopsy. The latter however is indicated only under special circumstances. No specific therapy is available, but treatment includes stopping the offending agent, corticosteroids and other immunosuppressive agents, and when indicated renal supportive therapy. Prognosis in general is good but some cases might be left with chronic renal damage.


Acute kidney injury Corticosteroids Drug reaction Eosinophiluria Interstitium Tubules 


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© Springer Nature Singapore Pte Ltd. 2019

Authors and Affiliations

  1. 1.Division of Pediatric Nephrology, Children’s Mercy Hospital Kansas CityUniversity of Missouri at Kansas CityKansas CityUSA

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