DOHaD Cohort Studies and Public Health Implications in Japan

  • Kohta SuzukiEmail author
Part of the Current Topics in Environmental Health and Preventive Medicine book series (CTEHPM)


Because the “Developmental Origins of Health and Disease (DOHaD)” hypothesis recently became widely known in a medical research area, fetal and childhood environment has been drawing more attention. In addition, based on the DOHaD, childhood growth trajectories, which are described by multilevel analysis, might be important in examining the effects of early-life environment. Therefore, it becomes more important to establish epidemiological evidence related to DOHaD from population-based birth cohort studies which include the study that uses the dataset from some public health activities. Moreover, it is also important to apply the findings from these studies to public health. In this chapter, some nationwide and local birth cohort studies and the results related to DOHaD from these studies are introduced. For instance, the association between maternal smoking status during pregnancy and birthweight from “Japanese Environment and Children’s Study” which is conducted by the Ministry of Environment, and childhood growth trajectories according to maternal smoking status during pregnancy from Project Koshu, are described.


Birth cohort study Public health Japan 



Body mass index


Confidence interval


Diabetes mellitus


Developmental Origins of Health and Disease


Gestational diabetes mellitus


Hyperemesis gravidarum


Japan Environment and Children’s Study


Low birth weight




Nausea and vomiting in early pregnancy


Odds ratio


Pregnancy-induced hypertension


Standard deviation




Current smokers



I thank the participants of these studies, the JECS staff and the collaborating hospitals and clinics, the staff of the Administrative Office of Koshu City and current and former members of the Department Health Sciences and the Center for Birth Cohort Studies, University of Yamanashi.


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Copyright information

© Springer Nature Singapore Pte Ltd. 2019

Authors and Affiliations

  1. 1.Department of Health and Psychosocial MedicineAichi Medical University School of MedicineNagakuteJapan

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