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Ayurvedic Rasayana Therapy: A Rational Understanding Necessary for Mass Benefits

  • Sanjeev Rastogi
  • Subhash C. Lakhotia
  • Ram H. Singh
Chapter

Abstract

Rasayana is a branch of Ayurveda (Oriental health-care system originated in India) which deals with drugs, formulations, food, and lifestyle suggestive of anti- or rather delaying aging effects. Such approaches, collectively called as Rasayana, are proclaimed to induce qualitative improvements at cellular and probably at molecular levels eventually leading to a delay in aging process. Delayed aging resulting as a consequence of Rasayana intake is reflected through sustained youthfulness both in perceptible and functional terms. In the process of delaying the aging, Rasayana may eventually reduce the incidence of morbidities which are degenerative in nature and hence are related to aging. Seeing the global interest toward antiaging, delaying aging, and healthy aging and also seeing the globally increasing proportion of elderly population by virtue of increasing life span, Rasayana proposition of Ayurveda seems highly promising as a measure to reduce the burden associated with increasing age. To achieve this objective, however, this ancient science is required to be evaluated and tested rigorously in tune to current scientific understanding in order to make it applicable for the mass benefits. This chapter reviews in depth the concepts of Rasayana, as are ingrained in Ayurveda, looks critically at the gaps in the existing knowledge, and suggests the quest for the knowledge which is required to translate this wisdom into an understanding which is dependably and reproducibly applicable in terms of its desired outcomes.

Keywords

Rasayana Rejuvenation Antiaging Super nutrition Delayed aging Age-related morbidities 

References

  1. 1.
    Wenzel U. Nutrition, sirtuins and aging. Genes Nutr. 2006;1(2):85–93.  https://doi.org/10.1007/BF02829950.CrossRefPubMedPubMedCentralGoogle Scholar
  2. 2.
    Savrikar SS, Ravishankar B. Introduction to “Rasashaastra” the iatrochemistry of Ayurveda. Afr J Tradit Complement Altern Med. 2011;8(5 Suppl):66–82.  https://doi.org/10.4314/ajtcam.v8i5S.1. CrossRefPubMedPubMedCentralGoogle Scholar
  3. 3.
    Aunan JR, Watson MM, Hagland HR, Søreide K. Molecular and biological hallmarks of ageing. Br J Surg. 2016;103:e29–46.CrossRefGoogle Scholar
  4. 4.
    Mendoza-Núñez VM. What is the onset age of human aging and old age? Int J Gerontol. 2016;10:56.  https://doi.org/10.1016/j.ijge.2015.06.0042015.CrossRefGoogle Scholar
  5. 5.
    Hayflick L, Moorhead PS. The serial cultivation of human diploid cell strains. Exp Cell Res. 1961;25:585–621.CrossRefGoogle Scholar
  6. 6.
    Childs BG, Gluscevic M, Baker DJ, Laberge R-M, Marquess D, Dananberg J, van Deursen JM. Senescent cells: an emerging target for diseases of ageing. Nat Rev Drug Discov. 2017;16:718–35.CrossRefGoogle Scholar
  7. 7.
    Weber CR. Dynamic properties of the tight junction barrier. Ann N Y Acad Sci. 2012;1257:77–84.  https://doi.org/10.1111/j.1749-6632.2012.06528.CrossRefPubMedPubMedCentralGoogle Scholar
  8. 8.
    Mälkki Y, Virtanen E. Gastrointestinal effects of oat bran and oat gum: a review. LWT Food Sci Technol. 2001;34(6):337–47.CrossRefGoogle Scholar
  9. 9.
    Gaur BL, Commentary on Charaka Samhita. New Delhi: Rasthriya Ayurveda Vidyapeeth; 2011.Google Scholar
  10. 10.
    How homes kept cool before the age of AC. http://blog.solarcity.com/how-homes-kept-cool-before-the-age-of-ac/. Last accessed on 29 Oct 2017.
  11. 11.
    Rastogi S, Chaudhari P. Convalescent food practices in Ayurveda. In: Rastogi S, editor. Ayurvedic science of food and nutrition. New York: Springer; 2014. p. 67–80.Google Scholar
  12. 12.
    Williams JM, Duckworth CA, Burkitt MD, Watson AJM, Campbell BJ, Pritchard DM. Epithelial cell shedding and barrier function: a matter of life and death at the small intestinal villus tip. Vet Pathol. 2015;52(3):445–55.  https://doi.org/10.1177/0300985814559404.CrossRefPubMedPubMedCentralGoogle Scholar
  13. 13.
    Mayhew TM, Myklebust R, Whybrow A, et al. Epithelial integrity, cell death and cell loss in mammalian small intestine. Histol Histopathol. 1999;14(1):257–67. [PubMed].PubMedGoogle Scholar
  14. 14.
    Boss GR, Seegmiller JE. Age-related physiological changes and their clinical significance. West J Med. 1981;135(6):434–40.PubMedPubMedCentralGoogle Scholar
  15. 15.
    Nigam Y, Knight J, Bhattacharya S, Bayer A. Physiological changes associated with aging and immobility. J Aging Res. 2012;1:Article ID 468469, 2 pages.  https://doi.org/10.1155/2012/468469.CrossRefGoogle Scholar
  16. 16.
    Wheeler HE, Kim SK. Genetics and genomics of human ageing. Philos Trans Roy Soc B Biol Sci. 2011;366(1561):43–50.  https://doi.org/10.1098/rstb.2010.0259.CrossRefGoogle Scholar
  17. 17.
    Horvath S. DNA methylation age of human tissues and cell types. Genome Biol. 2013;14(10):R115.CrossRefGoogle Scholar
  18. 18.
    Singh RH, Rastogi S. Rasayana therapy and rejuvenation. In: Rastogi S, editor. Evidence-based practice in complementary and alternative medicine. Berlin: Springer; 2012.Google Scholar
  19. 19.
    Ornish D, Lin J, Chan JM, et al. Effect of comprehensive lifestyle changes on telomerase activity and telomere length in men with biopsy-proven low-risk prostate cancer: 5-year follow-up of a descriptive pilot study. Lancet Oncol. 2013;14(11):1112–20.  https://doi.org/10.1016/S1470-2045(13)70366-8.CrossRefPubMedGoogle Scholar
  20. 20.
    Shrivastava S. Commentary on Sharangadhara Samhita. Varanasi: Chaukhambha Orientalia; 1999.Google Scholar
  21. 21.
    Life expectancy at birth, total (years). https://data.worldbank.org/indicator/SP.DYN.LE00.IN. Last accessed on 22 Oct 2017.
  22. 22.
    Metrics: disability-adjusted life year (DALY). http://www.who.int/healthinfo/global_burden_disease/metrics_daly/en/. Last accessed on 30 Oct 2017.
  23. 23.
    Everett JS, Budescu M, Sommers MS. Making sense of skin color in clinical care. Clin Nurs Res. 2012;21(4):495–516.  https://doi.org/10.1177/1054773812446510.CrossRefPubMedPubMedCentralGoogle Scholar
  24. 24.
    Farage MA, Miller KW, Elsner P, Maibach HI. Characteristics of the aging skin. Adv Wound Care. 2013;2(1):5–10.  https://doi.org/10.1089/wound.2011.0356.CrossRefGoogle Scholar
  25. 25.
    Diego MA, Field T. Moderate pressure massage elicits a parasympathetic nervous system response. Int J Neurosci. 2009;119(5):630–8.  https://doi.org/10.1080/00207450802329605.CrossRefPubMedGoogle Scholar
  26. 26.
    Valacchi G, Lim Y, Belmonte G, Miracco C, Zanardi I, Bocci V, Travagli V. Ozonated sesame oil enhances cutaneous wound healing in SKH1 mice. Wound Repair Regen. 2011;19:107–15.  https://doi.org/10.1111/j.1524-475X.2010.00649.x.CrossRefPubMedGoogle Scholar
  27. 27.
    Dhar S, Banerjee R, Malakar R. Oil massage in babies: Indian perspectives. Indian J Paediatr Dermatol. 2013;14:1–3.CrossRefGoogle Scholar
  28. 28.
    Mirmohammadali M, Hosseini-Baharanchi FS, Dehkordi ZR, Bekhradi R, Delaram M. The effect of massage with oils on the growth of term infants: a randomized controlled trial. Open J Pediatr. 2015;5(3):223–31.  https://doi.org/10.4236/ojped.2015.53034.CrossRefGoogle Scholar
  29. 29.
    Kulkarni R, Girish KJ, Kumar A. Nootropic herbs (Medhya Rasayana) in Ayurveda: an update. Pharmacogn Rev. 2012;6(12):147–53.  https://doi.org/10.4103/0973-7847.99949.CrossRefPubMedPubMedCentralGoogle Scholar
  30. 30.
    Shastri KN, Chaturvedi GN. Charaka Samhita. Varanasi: Chaukhambha Bharati Academy; 1986.Google Scholar
  31. 31.
    Ali M. A brief history of Indian alchemy covering pre-Vedic to Vedic and Ayurvedic period (circa 400 B.C.-800 A.D.). Bull Indian Inst Hist Med Hyderabad. 1993;23(2):151–66.PubMedGoogle Scholar
  32. 32.
    Dwivedi V, Anandan EM, Mony RS, Muraleedharan TS, Valiathan MS, Mutsuddi M, Lakhotia SC. In vivo effects of traditional ayurvedic formulations in Drosophila melanogaster model relate with therapeutic applications. PLoS One. 2012;7:e37113.CrossRefGoogle Scholar
  33. 33.
    Dwivedi V, et al. Ayurvedic Amalaki Rasayana and Rasa-Sindoor suppress neurodegeneration in fly models of Huntington’s and Alzheimer’s diseases. Curr Sci. 2013;105:1711–23.Google Scholar
  34. 34.
    Saba K, et al. Energetics of excitatory and inhibitory neurotransmission in aluminum chloride model of Alzheimer’s disease: reversal of behavioral and metabolic deficits by Rasa Sindoor. Front Mol Neurosci. 2017;10:323.  https://doi.org/10.3389/fnmol.2017.00323.eCollection2017. CrossRefPubMedPubMedCentralGoogle Scholar
  35. 35.
    Ramanan N, Lahiri D, Rajput P, et al. Investigating structural aspects to understand the putative/claimed non toxicity of the Hg based ayurvedic drug Rasasindura using XAFS. J Synchrotron Rad. 2015;22:1233–41.  https://doi.org/10.1107/S1600577515012473.CrossRefGoogle Scholar
  36. 36.
    Mukhi P, Mohapatra S, Bhattacharjee M, et al. Mercury based drug in ancient India: the red sulfide of mercury in nanoscale. J Ayurveda Integr Med. 2017;8(2):93–8.  https://doi.org/10.1016/j.jaim.2017.01.009.CrossRefPubMedPubMedCentralGoogle Scholar
  37. 37.
    Dwivedi V, Lakhotia SC. Ayurvedic Amalaki Rasayana promotes improved stress tolerance and thus has anti-aging effects in Drosophila melanogaster. J Biosci. 2016;41(4):697–711.CrossRefGoogle Scholar
  38. 38.
    Swain U, Sindhu KK, Boda U, et al. Studies on the molecular correlates of genomic stability in rat brain cells following Amalaki rasayana therapy. Mech Aging Dev. 2012;133:112–7.CrossRefGoogle Scholar
  39. 39.
    Guruprasad KP, Dash S, Shivakumar MB, et al. Influence of Amalaki Rasayana on telomerase activity and telomere length in human blood mononuclear cells. J Ayurveda Integr Med. 2017;8(2):105–12.  https://doi.org/10.1016/j.jaim.2017.01.007. Epub 2017 Jun 9.CrossRefPubMedPubMedCentralGoogle Scholar
  40. 40.
    Tiwari V, Saba K, Veeraiah P, Jose J, Lakhotia SC, Patel AB. Amalaki Rasayana improved memory and neuronal metabolic activity in AbPP-PS1 mouse model of Alzheimer’s disease. J Biosci. 2017;42:363–71.  https://doi.org/10.1007/s12038-017-9692-7.CrossRefPubMedGoogle Scholar
  41. 41.
    Kumar V, Aneesh KA, Kshemada K, et al. Amalaki Rasayana, a traditional Indian drug enhances cardiac mitochondrial and contractile functions and improves cardiac function in rats with hypertrophy. Sci Rep. 2017;7:8588.  https://doi.org/10.1038/s41598-017-09225-x.CrossRefPubMedPubMedCentralGoogle Scholar
  42. 42.
    Ong AD, Patterson A. Eudaimonia, aging, and health: a review of underlying mechanisms. In: Vittersø J, editor. Handbook of Eudaimonic Well-being. International handbooks of quality-of-life. Cham: Springer; 2016.Google Scholar
  43. 43.
    Rastogi S, Chaudhari P. Ethics as a modality affecting health and healthcare practice: revealing the real strengths of traditional healthcare. Asian Bioethics Rev. 2015;7(4):371–9.  https://doi.org/10.1353/asb.2015.0030.CrossRefGoogle Scholar
  44. 44.
    Lederberg J. Molecular biology, eugenics and euphenics. Nature. 1963;198:428–9.CrossRefGoogle Scholar
  45. 45.
    Patwardhan B, Mutalik G, Tillu G. Integrative approaches for health: biomedical research, ayurveda and yoga. London: Academic Press; 2016.Google Scholar
  46. 46.
    Valiathan MS. Ayurvedic biology: the first decade. Proc Indian Natl Sci Acad. 2016;82(1):13–9.CrossRefGoogle Scholar
  47. 47.
    Lakhotia SC. Ayurvedic biology—an unbiased approach to understand traditional health-care system. Proc Indian Natl Sci Acad. 2016;82(1):1–3.CrossRefGoogle Scholar
  48. 48.
    Valiathan MS. Ayurveda and modern science. Aryavaidyan. 2017;XXX(3):5–9.Google Scholar
  49. 49.
    Patwardhan B. Bridging Ayurveda with evidence-based scientific approaches in medicine. EPMA J. 2014;5(1):19.CrossRefGoogle Scholar
  50. 50.
    Lakhotia SC. Validation of Ayurvedic formulations in animal models requires stringent scientific rigor. J Ayurveda Integr Med. 2010;3:171–2.CrossRefGoogle Scholar
  51. 51.
    Valiathan MS. Ayurvedic Biology: a decadal vision document. Bengaluru: Indian Academy of Science; 2006.Google Scholar
  52. 52.
    Wolbring G. Eugenics, euthenics, euphenics: the underlying issue is that someone decides, based on values, which characteristics should be part of society and which are not. GeneWatch. 1999;12(3):8–10.PubMedGoogle Scholar
  53. 53.
    Chyawanprash market in India. http://www.mbarendezvous.com/general-awareness/chyawanprash-market-in-india/. Last accessed 5 Nov 2017.
  54. 54.
  55. 55.
    Savaliya AA, Shah RP, Prasad B, Singh SJ. Screening of Indian aphrodisiac ayurvedic/herbal healthcare products for adulteration with sildenafil, tadalafil and/or vardenafil using LC/PDA and extracted ion LC–MS/TOF. J Pharm Biomed Anal. 2010;52(3):406–9.CrossRefGoogle Scholar
  56. 56.
    Industry Scenario. http://vibrantAyurveda.in/?page_id=2083. Last accessed on 5 Nov 2017.
  57. 57.
    AnanthaNarayana DB, Durg S, RamManohar P, Mahapatra A, Aramya AR. Chyawanprash: a review of therapeutic benefits as in authoritative texts and documented clinical literature. J Ethnopharmacol. 2017;197:52–60.  https://doi.org/10.1016/j.jep.2016.07.078.CrossRefGoogle Scholar
  58. 58.
    Yadav JS, Thakur S, Chadha P. Chyawanprash Awaleha: a genoprotective agent for bidi smokers. Int J Hum Genet. 2003;3(1):33–8.CrossRefGoogle Scholar
  59. 59.
    Caring for our elders: early response India Ageing Report 2017. http://india.unfpa.org/sites/default/files/pub-pdf/India%20Ageing%20Report%20-%202017%20%28Final%20Version%29.pdf. Last accessed on 5 Nov 2017.

Copyright information

© Springer Nature Singapore Pte Ltd. 2019

Authors and Affiliations

  • Sanjeev Rastogi
    • 1
  • Subhash C. Lakhotia
    • 2
  • Ram H. Singh
    • 3
  1. 1.Department of Kaya ChikitsaState Ayurvedic College and Hospital, Lucknow UniversityLucknowIndia
  2. 2.Cytogenetics Laboratory, Department of ZoologyBanaras Hindu UniversityVaranasiIndia
  3. 3.Department of Kaya Chikitsa, Faculty of AyurvedaInstitute of Medical Sciences, Banaras Hindu UniversityVaranasiIndia

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