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Chemical Synthesis of Boranophosphate Deoxy-ribonucleotides

  • Yohei Nukaga
  • Takeshi Wada
Chapter

Abstract

Boranophosphate deoxyribonucleotides, in which a non-bridging oxygen atom of each phosphodiester internucleotidic linkage is replaced by a BH3 group, are useful as therapeutic agents owing to affinity for complementary RNA, nuclease resistance, RNase H activity, efficient cellular uptake, and potency for gene suppression. Over past two decades, chemists have tried to develop an efficient method for the chemical synthesis of boranophosphate deoxyribonucleotides. In this review, recent studies on the synthesis of boranophosphate deoxyribonucleotides are focused.

Keywords

Boranophosphate DNA Stereodefined boranophosphate DNA Solid-phase synthesis Stereocontrolled synthesis H-phosphonate approach Phosphoramidite approach Boranophosphotriester approach H-boranophosphonate approach Oxazaphospholidine approach 

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Copyright information

© Springer Nature Singapore Pte Ltd. 2018

Authors and Affiliations

  1. 1.Department of Medicinal and Life Science, Faculty of Pharmaceutical SciencesTokyo University of ScienceNodaJapan

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