Hashimoto’s Thyroiditis or Papillary Carcinoma
The nuclei of the oxyphilic or non-oxyphilic follicular epithelium in Hashimoto’s thyroiditis often exhibit considerable nuclear atypia, showing a range of nuclear changes that mimic those encountered in papillary thyroid carcinoma. Syncytial tissue fragments with or without any architectural configurations; enlarged nuclei with finely granular, powdery, or watery chromatin and nuclear contour irregularity; nuclear pseudoinclusions; nuclear grooves; and multiple micro- and/or macronucleoli could be applicable as the minimal criteria for the cytological diagnosis of papillary carcinoma. It is essential to remain in conservative diagnosis until the minimal criteria of papillary thyroid carcinoma is fulfilled. One single cytological feature of papillary carcinoma proves to be meaningless to conclude malignancy in Hashimoto’s thyroiditis since Hashimoto’s thyroiditis shows several overlapping features with papillary carcinoma.
KeywordsHashimoto’s thyroiditis Nuclear atypia Minimal criteria Diagnostic system Papillary carcinoma
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