Cribriform-Morular Variant of Papillary Thyroid Carcinoma
Cribriform-morular variant of papillary thyroid carcinoma (CMV-PTC) is rare and constitutes less than 0.5% of all PTC. CMV-PTC typically affects young adults with a female predominance, showing a female-to-male ratio of 17:1. It is commonly associated with familial adenomatous polyposis and has a germline mutation in the adenomatous polyposis coli (APC) gene. However, sporadic form without FAP has been also reported. Preoperative diagnosis of CMV-PTC is important. As CMV-PTC with FAP usually displays multifocal nodules, total thyroidectomy is required. On the other hand, lobectomy is sufficient for sporadic cases because of solitary nodule and excellent prognosis. In this chapter, we describe the diagnostic clue of CMV-PTC.
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