Inhibition of mTOR Signalling: A Potential Anti-aging Drug Strategy
Maintenance of cellular energy homeostasis, counterbalanced by cellular stress response and an adequate cellular housekeeping are the hallmarks of improved healthspan and lifespan. Mammalian target of rapamycin (mTOR) is a central cell growth regulator that integrates cellular growth and proliferation with nutrient status of the cell. It is an intracellular nutrient sensor that controls protein synthesis, cell growth and metabolism. mTOR turns off stress resistance and autophagy and activates translation. Available scientific evidence endorses that molecular inhibition of this pathway slows aging, extends lifespan and improves symptoms of diverse array of age-related diseases in wide range of species. Rapamycin, a small molecule inhibitor of the protein kinase mTOR, has been found to extend the lifespan of model organisms including mice. Many of such inhibitors of this pathway are already characterized and clinically approved. In the present chapter, we summarize current understanding of mTOR and its role in aging and age-related disease progression.
KeywordsAging Autophagy Mammalian target of rapamycin Protein synthesis Rapamycin
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