P2Y Receptor

  • Senthilkumar Rajagopal
  • Murugavel Ponnusamy


Purinergic receptors (P2Ys) are rhodopsin-like GPCR (metabotropic receptors) that are activated by extracellular nucleotides (ATP, ADP, UTP and UDP). They stimulate a wide range of signaling pathways through activation of a variety of G proteins. P2Y family contains 8 members and they are grouped as P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6 and P2Y11) and P2Y12-like receptors (P2Y12, P2Y13, P2Y14) based on their amino acid sequence homology and preference for ligands. These receptors are ubiquitously expressed in the biological system and they have unavoidable role in many physiological functions including neurotransmission, hormone secretion, blood vessel contraction, homeostasis and metabolism. As P2Y receptors can interact and/or heterodimerize with various GPCRs and other family receptors, they are now gaining much attention as a potential therapeutic target for various disorders including stroke, epilepsy and cancer. This chapter illustrates the classification, characteristic features and distribution of members of P2Y receptor family. In addition, the current knowledge of physiological and pathological functions of P2Y receptors are described.


Biochemical properties Classification Purinergic P2Y receptors Physiological role Pathological role 


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Copyright information

© Springer Nature Singapore Pte Ltd. 2018

Authors and Affiliations

  • Senthilkumar Rajagopal
    • 1
  • Murugavel Ponnusamy
    • 2
  1. 1.Department of BiochemistryRayalaseema UniversityKurnoolIndia
  2. 2.Center for Developmental Cardiology, Institute for Translational MedicineQingdao UniversityQingdaoChina

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