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Stem Cell-Based Therapy for Ischemic Stroke

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Advancement in the Pathophysiology of Cerebral Stroke

Abstract

Stroke is still a leading cause of death and physical disability among adults. For stroke patients, there is a need for improved and effective therapy. Tissue plasminogen activator is a single FDA-approved drug available for treatment with short window of opportunity (it must be applied within 4.5 h of symptom onset). Over the years, several clinical trials of potential drugs have failed to show positive results. Stem cell therapy currently holds great promise as a neuroregenerative medical strategy for stroke by replenishing the lost brain functions. In the clinical arena of stroke therapy, animal studies revealed that the therapeutic efficacy of stem cells, including mesenchymal stem cells, neural stem cells, embryonic stem cells, and inducible pluripotent stem cells, may be due to angiogenesis, endogenous neurogenesis, neurorestoration, neuroprotection, and modulation of inflammation and immune responses. In this chapter, the current status, therapeutic potential, and the detailed factors of stem cell-based therapy for ischemic stroke are presented and discussed.

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Authors and Affiliations

  1. School of Biomedical Engineering, Indian Institute of Technology (Banaras Hindu University), Varanasi, Uttar Pradesh, India

    Gaurav Kumar, Sumedha Mukherjee, Amit Kumar Tripathi & Ranjana Patnaik

  2. Neurotherapeutics Laboratory, Department of Pharmaceutical Engineering and Technology, Indian Institute of Technology (Banaras Hindu University), Varanasi, Uttar Pradesh, India

    Pankaj Paliwal & Sairam Krishnamurthy

Authors
  1. Gaurav Kumar
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  2. Sumedha Mukherjee
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  3. Pankaj Paliwal
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  4. Amit Kumar Tripathi
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  5. Sairam Krishnamurthy
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  6. Ranjana Patnaik
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Corresponding author

Correspondence to Gaurav Kumar .

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Editors and Affiliations

  1. School of Biomedical Engineering, Indian Institute of Technology (Banaras Hindu University), Varanasi, Uttar Pradesh, India

    Ranjana Patnaik

  2. School of Biomedical Engineering, Indian Institute of Technology (Banaras Hindu University), Varanasi, Uttar Pradesh, India

    Amit Kumar Tripathi

  3. Department of Zoology, Banaras Hindu University, Varanasi, Uttar Pradesh, India

    Ashish Dwivedi

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Kumar, G., Mukherjee, S., Paliwal, P., Tripathi, A.K., Krishnamurthy, S., Patnaik, R. (2019). Stem Cell-Based Therapy for Ischemic Stroke. In: Patnaik, R., Tripathi, A., Dwivedi, A. (eds) Advancement in the Pathophysiology of Cerebral Stroke. Springer, Singapore. https://doi.org/10.1007/978-981-13-1453-7_9

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