Circular RNAs pp 299-308 | Cite as

Functional Role of Circular RNA in Regenerative Medicine

  • Richard Y. Cao
  • Qiying Dai
  • Qing Li
  • Jian Yang
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1087)


Every year, millions of people around the world suffer from different forms of tissue trauma. Regenerative medicine refers to therapy that replaces the injured organ or cells. Stem cells are the frontiers and hotspots of current regenerative medicine research. Circular RNAs (circRNAs) are essential for the early development of many species. It was found that they could guide stem cell differentiation through interacting with certain microRNAs (miRNAs). Based on this concept, it is meaningful to look into how circRNAs influence stem cells and its role in regenerative medicine. In this chapter we will discuss the functional roles of circRNAs in the prevention, repair, or progression of chronic diseases, through the communication between stem cells.


Circular RNA Regenerative medicine Stem cell 


Competing Financial Interests

The authors declare no competing financial interests.


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Copyright information

© Springer Nature Singapore Pte Ltd. 2018

Authors and Affiliations

  • Richard Y. Cao
    • 1
  • Qiying Dai
    • 2
    • 3
  • Qing Li
    • 1
  • Jian Yang
    • 1
  1. 1.Zhongshan-Xuhui Hospital, Fudan University/Shanghai Clinical Research Center, Chinese Academy of SciencesShanghaiChina
  2. 2.MetroWest Medical CenterFraminghamUSA
  3. 3.Department of CardiologyFirst Affiliated Hospital of Nanjing Medical UniversityNanjingChina

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