Circular RNAs pp 245-257 | Cite as

Circular RNA in Liver: Health and Diseases

  • Meiyi Song
  • Lu Xia
  • Mengxue Sun
  • Changqing Yang
  • Fei WangEmail author
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1087)


Circular RNA (circRNA) is an important class of noncoding RNA characterized by covalently closed continuous loop structures. In recent years, the various functions of circRNAs have been continuously documented, including effects on cell proliferation and apoptosis and nutrient metabolism. The liver is the largest solid organ in mammals, and it also performs many functions in the body, which is considered to be the busiest organ in the body. At the same time, the liver is vulnerable to multiple pathogenic factors, causing various acute and chronic liver diseases. The pathogenesis of liver disease is still not fully understood. As a rising star for the past few years, circRNAs have been proven involved in the regulation of liver homeostasis and disease. This chapter will explain the role of circRNAs in liver health and diseases and sort out the confusion in the present study.


Circular RNA Liver MicroRNA Noncoding RNA 



This work was supported by the grants from National Natural Science Foundation of China (81670571 and 81370559 C. Yang; 81400635 to F. Wang), Joint Projects in Major Diseases funding from Shanghai Municipal Commission of Health and Family Planning (2014ZYJB0201 to C. Yang), Joint Projects for Novel Frontier Technology in Shanghai Municipal Hospital from Shanghai Municipal Commission of Health and Family Planning (SHDC12014122 to C. Yang), Shanghai Medical Guide Project from Shanghai Science and Technology Committee (14411971500 to F. Wang), grants from Chinese Foundation for Hepatitis Prevention and Control (TQGB20140141 to F. Wang), and funds from Shanghai Innovation Program (12431901002 to C. Yang).

Competing Financial Interests

The authors declare no competing financial interests.


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Copyright information

© Springer Nature Singapore Pte Ltd. 2018

Authors and Affiliations

  • Meiyi Song
    • 1
  • Lu Xia
    • 1
  • Mengxue Sun
    • 1
  • Changqing Yang
    • 1
  • Fei Wang
    • 1
    Email author
  1. 1.Division of Gastroenterology and Hepatology, Digestive Disease Institute, Shanghai Tongji HospitalTongji University School of MedicineShanghaiChina

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