Circular RNAs pp 191-204 | Cite as

Circular RNAs in Cardiovascular Diseases

  • Lijun Wang
  • Xiangmin Meng
  • Guoping Li
  • Qiulian Zhou
  • Junjie XiaoEmail author
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1087)


Circular RNAs (circRNAs), a group of circular RNA molecules with a 3′,5′-phosphodiester bond at the junction site, are generated by back-splicing of precursor mRNAs. Most of the circular RNAs originate from the exon region of the encoded protein, and some are derived from intron regions, antisense transcripts, or long noncoding RNAs. Circular RNAs are abundantly in eukaryotic transcriptome and participate in various biological processes. It is closely associated with various diseases such as tumors, diabetes, nervous system diseases, and cardiovascular diseases. In cardiovascular system, numerous circRNAs have been identified and involved in important processes of cardiovascular development and diseases. Here we will review the latest research progress of circular RNA in cardiovascular diseases. Also, we will outline the specific examples of circRNAs involved in cardiovascular system regulatory effects, including act as miRNA sponges, interaction with RNA-binding proteins, regulated by RNA-binding proteins and serve as biomarkers. In addition, potential mechanisms underlying the regulatory role of circRNAs in cardiovascular diseases will be discussed.


Circular RNA microRNA RNA-binding protein Cardiovascular diseases 



The authors thank members of the Cardiac Regeneration and Ageing Lab in Shanghai University for the discussion. Due to space restrictions, the authors cannot cite all the relevant literature in the field. The authors apologize to those colleagues whose work contributed significantly. This work was supported by the grants from the National Natural Science Foundation of China (81722008, 91639101, and 81570362 to JJ Xiao), the Innovation Program of Shanghai Municipal Education Commission (2017-01-07-00-09-E00042 to JJ Xiao), the grant from the Science and Technology Commission of Shanghai Municipality (17010500100 to JJ Xiao), and the development fund for Shanghai talents (to JJ Xiao).

Competing Financial Interests

The authors declare no competing financial interests.


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Copyright information

© Springer Nature Singapore Pte Ltd. 2018

Authors and Affiliations

  • Lijun Wang
    • 1
    • 2
  • Xiangmin Meng
    • 1
    • 2
  • Guoping Li
    • 3
  • Qiulian Zhou
    • 4
    • 1
    • 2
  • Junjie Xiao
    • 5
    Email author
  1. 1.Cardiac Regeneration and Ageing Lab, Institute of Cardiovascular Sciences, School of Life ScienceShanghai UniversityShanghaiChina
  2. 2.Shanghai Key Laboratory of Bio-Energy Crops, School of Life SciencesShanghai UniversityShanghaiChina
  3. 3.Cardiovascular Division of the Massachusetts General Hospital, Harvard Medical SchoolBostonUSA
  4. 4.Shanghai Applied Radiation Institute, School of Environmental and Chemical EngineeringShanghai UniversityShanghaiChina
  5. 5.School of Life Science, Institute of Cardiovascular SciencesShanghai UniversityShanghaiChina

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