Entry and Deposit of Aluminum in the Brain

  • Linping Wang
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1091)


Aluminum, as a known neurotoxicant, contributes to cognitive dysfunction and may contribute to Alzheimer’s disease. The important reason is that aluminum can enter and be deposited in the brain. There have been three routes by which aluminum could enter the brain from systemic circulation or the site of absorption. Aluminum fluxes into brain across the blood-brain barrier (BBB), the choroid plexuses and the nasal cavity. Some factors, such as the increasing of the blood-brain barrier permeability, citric acid and parathyroid hormone (PTH), and vitamin D, can promote aluminum to enter the brain. But the redistribution of aluminum out of the brain is slow, so aluminum can be deposited in the brain for a long time.


Aluminum Entry Deposit Brain 


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Copyright information

© Springer Nature Singapore Pte Ltd. 2018

Authors and Affiliations

  1. 1.Shanxi Medical UniversityTaiyuanPeople’s Republic of China

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