Case-Control Study of Idiopathic Pulmonary Fibrosis in Japan
With regard to risk factors for idiopathic pulmonary fibrosis (IPF), the results from a case-control study of a Japanese population were shown. Included in the study were 104 patients of IPF, aged 40 years or over, who had been diagnosed within the previous 2 years, in accordance with the most recent criteria. Control subjects, aged 40 years or over, consisted of 56 hospitalized patients diagnosed as having acute bacterial pneumonia and four outpatients with the common cold. Exposure to metal dust was related to an approximately tenfold increased risk of IPF. A significant increased risk of IPF was observed for smokers with 20.0–39.9 pack-years. Intake levels of saturated fatty acids and meat were independently related to an increased risk of IPF. Consumption of fruit in the second and third quartiles was associated with a statistically significant reduced risk of IPF. Having a child with a history of allergic rhinitis was significantly related to an increased risk of IPF. Epidemiological investigations regarding gene–environment interaction affecting the risk of IPF are required.
KeywordsCase-control study Japan Idiopathic pulmonary fibrosis Risk factor
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