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Risk Factors in Amyotrophic Lateral Sclerosis

  • Kazushi Okamoto
Chapter
Part of the Current Topics in Environmental Health and Preventive Medicine book series (CTEHPM)

Abstract

Amyotrophic lateral sclerosis (ALS) is a devastating and lethal adult-onset degenerative disease of the upper and lower motor neuron systems. It is of unknown etiology and affects the motor neurons in the spinal cord, leading to atrophy of the skeletal muscles, paralysis, and death within 2–5 years of symptom onset, often due to respiratory insufficiency. High incidence areas are located approximately on the 135 east longitude. Most cases of ALS are sporadic, with only 5–10% having a family history, suggesting that nongenetic factors have a greater effect on the development of ALS than genetic factors.

In this review, we introduce the major factors related to the development of ALS and provide data on gender and age group differences for the risk factors listed.

Keywords

Amyotrophic lateral sclerosis Risk factors Lifestyle Environment Medical condition 

References

  1. 1.
    Maruyama H, Morino H, Ito H, Izumi Y, Kato H, Watanabe Y, et al. Mutations of optineurin in amyotrophic lateral sclerosis. Nature. 2010;465:223–6.CrossRefPubMedGoogle Scholar
  2. 2.
    Turner MR, Hardiman O, Benatar M, Brooks BR, Chio A, de Carvalho M, et al. Controversies and priorities in amyotrophic lateral sclerosis. Lancet Neurol. 2013;12:310–22.CrossRefPubMedPubMedCentralGoogle Scholar
  3. 3.
    Gellera C, Castellotti B, Riggio MC, Silani V, Morandi L, Testa D, et al. Superoxide dismutase gene mutations in Italian patients with familial and sporadic amyotrophic lateral sclerosis: identification of three novel missense mutations. Neuromuscul Disord. 2001;11:404–10.CrossRefPubMedGoogle Scholar
  4. 4.
    Appel SH, Zhao W, Beers DR, Henkel JS. The microglial-motoneuron dialogue in ALS. Acta Myol. 2011;30:4–8.PubMedPubMedCentralGoogle Scholar
  5. 5.
    McGuire V, Longstreth WT Jr, Koepsell TD, van Belle G. Incidence of amyotrophic lateral sclerosis in three counties in western Washington state. Neurology. 1996;47(2):571–3.CrossRefPubMedGoogle Scholar
  6. 6.
    Traynor BJ, Codd MB, Corr B, Forde C, Frost E, Hardiman O. Incidence and prevalence of ALS in Ireland, 1995–1997: a population-based study. Neurology. 1999;52(3):504–9.CrossRefPubMedGoogle Scholar
  7. 7.
    Marin B, Boumédiene F, Logroscino G, Couratier P, Babron MC, Leutenegger AL, et al. Variation in worldwide incidence of amyotrophic lateral sclerosis: a meta-analysis. Int J Epidemiol. 2017 Feb 1;46(1):57–74.Google Scholar
  8. 8.
    Manjaly ZR, Scott KM, Abhinav K, et al. The sex ratio in amyotrophic lateral sclerosis: a population based study. Amyotroph Lateral Scler. 2010;11(5):439–42.CrossRefPubMedGoogle Scholar
  9. 9.
    Kihira T, Yoshida S, Hironishi M, Miwa H, Okamato K, Kondo T. Changes in the incidence of amyotrophic lateral sclerosis in Wakayama, Japan. Amyotroph Lateral Scler Other Motor Neuron Disord. 2005 Sep;6(3):155–63.CrossRefPubMedGoogle Scholar
  10. 10.
    Sejvar JJ, Holman RC, Bresee JS, Kochanek KD, Schonberger LB. Amyotrophic lateral sclerosis mortality in the United States, 1979–2001. Neuroepidemiology. 2005;25(3):144–52.CrossRefPubMedGoogle Scholar
  11. 11.
    Plato CC, Garruto RM, Galasko D, et al. Amyotrophic lateral sclerosis and parkinsonism-dementia complex of Guam: changing incidence rates during the past 60 years. Am J Epidemiol. 2003;157(2):149–57.CrossRefPubMedGoogle Scholar
  12. 12.
    Testa D, Lovati R, Ferrarini M, Salmoiraghi F, Filippini G. Survival of 793 patients with amyotrophic lateral sclerosis diagnosed over a 28-year period. Amyotroph Lateral Scler Other Motor Neuron Disord. 2004;5(4):208–12.CrossRefPubMedGoogle Scholar
  13. 13.
    Logroscino G, Traynor BJ, Hardiman O, et al. Incidence of amyotrophic lateral sclerosis in Europe. J Neurol Neurosurg Psychiatry. 2010;81(4):385–90.CrossRefPubMedGoogle Scholar
  14. 14.
    Cruz DC, Nelson LM, McGuire V, Longstreth WT Jr. Physical trauma and family history of neurodegenerative diseases in amyotrophic lateral sclerosis: a population-based case-control study. Neuroepidemiology. 1999;18(2):101–10.CrossRefPubMedGoogle Scholar
  15. 15.
    Kamel F, Umbach DM, Munsat TL, Shefner JM, Sandler DP. Association of cigarette smoking with amyotrophic lateral sclerosis. Neuroepidemiology. 1999;18(4):194–202.CrossRefPubMedGoogle Scholar
  16. 16.
    Al-Chalabi A, Fang F, Hanby MF, Leigh PN, Shaw CE, Ye W, et al. An estimate of amyotrophic lateral sclerosis heritability using twin data. J Neurol Neurosurg Psychiatry. 2010;81(12):1324–6.CrossRefPubMedPubMedCentralGoogle Scholar
  17. 17.
    Robberecht W, Aguirre T, Van den Bosch L, Tilkin P, Cassiman JJ, Matthijs G. D90A heterozygosity in the SOD1 gene is associated with familial and apparently sporadic amyotrophic lateral sclerosis. Neurology. 1996;47(5):1336–9.CrossRefPubMedGoogle Scholar
  18. 18.
    Andersen P. Amyotrophic lateral sclerosis associated with mutations in the CuZn superoxide dismutase gene. Curr Neurol Neurosci Rep. 2006;6(1):37–46.CrossRefPubMedGoogle Scholar
  19. 19.
    Renton AE, Majounie E, Waite A, et al. A hexanucleotide repeat expansion in C9ORF72 is the cause of chromosome 9p21-linked ALS-FTD. Neuron. 2011;72(2):257–68.CrossRefPubMedPubMedCentralGoogle Scholar
  20. 20.
    Gijselinck I, Van Langenhove T, van der Zee J, et al. A C9orf72 promoter repeat expansion in a Flanders-Belgian cohort with disorders of the frontotemporal lobar degeneration-amyotrophic lateral sclerosis spectrum: a gene identification study. Lancet Neurol. 2012;11(1):54–65.CrossRefGoogle Scholar
  21. 21.
    Millecamps S, Boillée S, Le Ber I, et al. Phenotype difference between ALS patients with expanded repeats in C9ORF72 and patients with mutations in other ALS-related genes. J Med Genet. 2012;49(4):258–63.CrossRefPubMedGoogle Scholar
  22. 22.
    Ishiura H, Takahashi Y, Mitsui J, Yoshida S, Kihira T, Kokubo Y, et al. C9ORF72 repeat expansion in amyotrophic lateral sclerosis in the Kii peninsula of Japan. Arch Neurol. 2012;69(9):1154–8.CrossRefPubMedGoogle Scholar
  23. 23.
    Okamoto K, Kihira T, Kondo T, Kobashi G, Washio M, Sasaki S, et al. Lifestyle factors and risk of amyotrophic lateral sclerosis: a case-control study in Japan. Ann Epidemiol. 2009;19(6):359–64.  https://doi.org/10.1016/j.annepidem.2009.01.015. Epub 2009 Apr 2CrossRefPubMedGoogle Scholar
  24. 24.
    Gallo V, Wark PA, Jenab M, Pearce N, Brayne C, Vermeulen R, et al. Prediagnostic body fat and risk of death from amyotrophic lateral sclerosis: the EPIC cohort. Neurology. 2013 Feb 26;80(9):829–38.  https://doi.org/10.1212/WNL.0b013e3182840689.CrossRefPubMedPubMedCentralGoogle Scholar
  25. 25.
    Alonso A, Logroscino G, Hernán MA. Smoking and the risk of amyotrophic lateral sclerosis: a systematic review and meta-analysis. J Neurol Neurosurg Psychiatry. 2010;81(11):1249–52.CrossRefPubMedGoogle Scholar
  26. 26.
    Pamphlett R, Ward EC. Smoking is not a risk factor for sporadic amyotrophic lateral sclerosis in an Australian population. Neuroepidemiology. 2012;38(2):106–13.CrossRefPubMedGoogle Scholar
  27. 27.
    Alonso A, Logroscino G, Jick SS, Hernán MA. Association of smoking with amyotrophic lateral sclerosis risk and survival in men and women: a prospective study. BMC Neurol. 2010 Jan 14;10:6.CrossRefPubMedPubMedCentralGoogle Scholar
  28. 28.
    Peters ME, Rao V, Bechtold KT, Roy D, Sair HI, Leoutsakos JM, et al. Head injury serum markers for assessing response to trauma: design of the HeadSMART study. Brain Inj. 2017;31(3):370–8.CrossRefPubMedGoogle Scholar
  29. 29.
    Binazzi A, Belli S, Uccelli R, Desiato MT, Talamanca IF, Antonini G, et al. An exploratory case control study on spinal and bulbar forms of amyotrophic lateral sclerosis in the province of Rome. Amyotroph Lateral Scler. 2009 Oct-Dec;10(5–6):361–9.CrossRefPubMedGoogle Scholar
  30. 30.
    Peters TL, Fang F, Weibull CE, Sandler DP, Kamel F, Ye W. Severe head injury and amyotrophic lateral sclerosis. Amyotroph Lateral Scler Frontotemporal Degener. 2013;14(4):267–72.CrossRefPubMedPubMedCentralGoogle Scholar
  31. 31.
    Beghi E, Logroscino G, Micheli A, Millul A, Perini M, Riva R, et al. Validity of hospital discharge diagnoses for the assessment of the prevalence and incidence of amyotrophic lateral sclerosis. Amyotrophic Lateral Scler. 2001;2:99–104.Google Scholar
  32. 32.
    Chen H, Richard M, Sandler DP, Umbach DM, Kamel F. Head injury and amyotrophic lateral sclerosis. Am J Epidemiol. 2007;166(7):810–6.CrossRefPubMedPubMedCentralGoogle Scholar
  33. 33.
    Szczygielski J, Mautes A, Steudel WI, Falkai P, Bayer TA, Wirths O. Traumatic brain injury: cause or risk of Alzheimer's disease? A review of experimental studies. J Neural Transm. 2005;112:1547–64.CrossRefPubMedGoogle Scholar
  34. 34.
    Goldman SM, Tanner CM, Oakes D, Bhudhikanok GS, Gupta A, Langston JW. Head injury and Parkinson's disease risk in twins. Ann Neurol. 2006;60:65–72.CrossRefPubMedGoogle Scholar
  35. 35.
    Hamidou B, Couratier P, Besançon C, Nicol M, Preux PM, Marin B. Epidemiological evidence that physical activity is not a risk factor for ALS. Eur J Epidemiol. 2014;29(7):459–75.CrossRefPubMedGoogle Scholar
  36. 36.
    Harwood CA, Westgate K, Gunstone S, Brage S, Wareham NJ, McDermott CJ, et al. Long-term physical activity: an exogenous risk factor for sporadic amyotrophic lateral sclerosis? Amyotroph Lateral Scler Frontotemporal Degener. 2016;17(5–6):377–84.CrossRefPubMedPubMedCentralGoogle Scholar
  37. 37.
    Longstreth WT, McGuire V, Koepsell TD, Wang Y, van Belle G. Risk of amyotrophic lateral sclerosis and history of physical activity: a population-based case-control study. Arch Neurol. 1998;55(2):201.CrossRefPubMedGoogle Scholar
  38. 38.
    Chio A, Benzi G, Dossena M, Mutani R, Mora G. Severely increased risk of amyotrophic lateral sclerosis among Italian professional football players. Brain. 2005;128(Pt 3):472–6.CrossRefGoogle Scholar
  39. 39.
    Chio A, Calvo A, Dossena M, Ghiglione P, Mutani R, Mora G. ALS in Italian professional soccer players: the risk is still present and could be soccer-specific. Amyotroph Lateral Scler. 2009;10(4):205–9.CrossRefPubMedGoogle Scholar
  40. 40.
    Savica R, Parisi JE, Wold LE, Josephs KA, Ahlskog JE. High school football and risk of neuro- degeneration: a community-based study. Mayo Clin Proc. 2012;87(4):335–40.CrossRefPubMedPubMedCentralGoogle Scholar
  41. 41.
    Pupillo E, Messina P, Giussani G, Logroscino G, Zoccolella S, Chiò A, et al. Physical activity and amyotrophic lateral sclerosis: a European population-based case-control study. Ann Neurol. 2014 May;75(5):708–16.CrossRefPubMedGoogle Scholar
  42. 42.
    Ingre C, Roos PM, Piehl F, Kamel F, Fang F. Risk factors for amyotrophic lateral sclerosis. Clin Epidemiol. 2015;7:181–93.PubMedPubMedCentralGoogle Scholar
  43. 43.
    Dearborn MJ, Hastings JE. Type a personality as a mediator of stress and strain in employed women. J Hum Stress. 1982;13:53–60.CrossRefGoogle Scholar
  44. 44.
    Orpen C. Type a personality as a moderator of the effects of role conflict, role ambiguity and role overload on individual strain. J Hum Stress. 1982;8:8–14.CrossRefGoogle Scholar
  45. 45.
    Okamoto K, Kihira T, Kokubo Y, Kuzuhara S. Gender and age differences in lifestyle factors and risk of amyotrophic lateral sclerosis; a case-control study in Japan. J Neurol Psychol August. 2017;5:1–4.CrossRefGoogle Scholar
  46. 46.
    Wu D, Liu B, Yin J, Xu T, Zhao S, Xu Q, et al. Detection of 8-hydroxydeoxyguanosine (8-OHdG) as a biomarker of oxidative damage in peripheral leukocyte DNA by UHPLC-MS/MS. J Chromatogr B Analyt Technol Biomed Life Sci. 2017;1064:1–6.CrossRefPubMedGoogle Scholar
  47. 47.
    Song Y, Leonard SW, Traber MG, Ho E. Zinc deficiency affects DNA damage, oxidative stress, antioxidant defenses, and DNA repair in rats. J Nutr. 2009;139:1626–31.CrossRefPubMedPubMedCentralGoogle Scholar
  48. 48.
    Wu LL, Chiou CC, Chang PY, et al. Urinary 8-OHdG: a marker of oxidative stress to DNA and a risk factor for cancer, atherosclerosis and diabetics. Clin Chim Acta. 2004;339:1–9.CrossRefPubMedGoogle Scholar
  49. 49.
    Sato S, Mizuno Y, Hattori N, et al. Urinary 8-hydroxydeoxyguanosine levels as a biomarker for progression of Parkinson disease. Neurology. 2005;64:1081–3.CrossRefPubMedGoogle Scholar
  50. 50.
    Kihira T, Okamoto K, Sakurai I, Arakawa Y, Wakayama I, Takamiya K, et al. Nutritional status and risk of amyotrophic lateral sclerosis in Japan. Intern Med. 2017;56(12):1497–506.CrossRefPubMedPubMedCentralGoogle Scholar
  51. 51.
    Morimoto S, Kuzuhara S, Kokubo Y. Increased oxidative stress in patients with amyotrophic lateral sclerosis/Parkinsonism-dementia complex in the Kii peninsula, Japan. Mov Disord. 2009 Jan 15;24(1):123–6.CrossRefPubMedGoogle Scholar
  52. 52.
    Yase Y. The pathogenesis of amyotrophic lateral sclerosis. Lancet. 1972;II:292–6.CrossRefGoogle Scholar
  53. 53.
    Garruto RM, Yanagihara R, Gajdusek DC, Arion DM. Concentrations of heavy metals and essential minerals in garden soil and drinking water in the western Pacific. In: Chen KM, Yase Y, (eds). Amyotrophic lateral sclerosis in Asia and Oseania. National Taiwan University, Shyan-Fu Chou, 1984: 265–330.Google Scholar
  54. 54.
    Kihira T, Okamoto K, Yoshida S, et al. Environmental characteristics and oxidative stress of inhabitants and patients with amyotrophic lateral sclerosis in a high-incidence area on the Kii peninsula, Japan. Intern Med. 2013;52:1479–86.CrossRefPubMedGoogle Scholar
  55. 55.
    Kihira T, Okamoto K, Sakurai I, Arakawa Y, Wakayama I, Takamiya K, et al. Lifestyle changes and oxidative stress in a high-incidence area of amyotrophic lateral sclerosis in the Southwestern Kii Peninsula, Japan. Intern Med. 2017;56(12):1497–506.CrossRefPubMedPubMedCentralGoogle Scholar
  56. 56.
    Taysi S, Cikman O, Kaya A, Demircan B, Gumustekin K, Yilmaz A, et al. Increased oxidant stress and decreased antioxidant status in erythrocytes of rats fed with zinc deficient diet. Biol Trace Elem Res. 2008;123(1–3):161–7.CrossRefPubMedGoogle Scholar
  57. 57.
    Dobson AW, Erikson KM, Aschner M. Manganese neurotoxicity. Ann N Y Acad Sci. 2004;1012:115–28.CrossRefPubMedGoogle Scholar
  58. 58.
    Roos PM, Lierhagen S, Flaten TP, Syversen T, Vesterberg O, Nordberg M. Manganese in cerebrospinal fluid and blood plasma of patients with amyotrophic lateral sclerosis. Exp Biol Med (Maywood). 2012;237(7):803–10.CrossRefGoogle Scholar
  59. 59.
    Allen DA, Yaqoob MM, Harwood SM. Mechanism of high glucose-induced apoptosis and its relationship to diabetic complications. J Nutr Biochem. 2005;16:705–13.CrossRefPubMedGoogle Scholar
  60. 60.
    Perez J, Ware MA, Chevalier S, Gougeon R, Bennett GJ, Shir Y. Dietary fat and protein interact in suppressing neuropathic pain-related disorders following a partial sciatic ligation injury in rats. Pain. 2004;111:297–305.CrossRefPubMedGoogle Scholar
  61. 61.
    Wang ZJ, Li GM, Nie BM, Lu Y, Yin M. Neuroprotective effect of stearic acid against oxidative stress via phosphatidylinositol 3-kinase pathway. Chem Biol Interact. 2006;160:80–7.CrossRefPubMedGoogle Scholar
  62. 62.
    Russo A, Izzo AA, Borrelli F, Renis M, Vanella A. Free radical scavenging capacity and protective effect of Bacopa monniera L. on DNA damage. Phytother Res. 2003;17(8):870–5.CrossRefPubMedGoogle Scholar
  63. 63.
    Okamoto K. Dietary antioxidant intake and risk of an amyotrophic lateral sclerosis in Japan. J Public Health. 2017;1(2):1–5.Google Scholar
  64. 64.
    Wang H, O'Reilly ÉJ, Weisskopf MG, Logroscino G, McCullough ML, Schatzkin A, et al. Vitamin E intake and risk of amyotrophic lateral sclerosis: a pooled analysis of data from 5 prospective cohort studies. Am J Epidemiol. 2011 Mar 15;173(6):595–602.CrossRefPubMedPubMedCentralGoogle Scholar
  65. 65.
    Okamoto K, Kihira T, Kobashi G, Washio M, Sasaki S, Yokoyama T, et al. Fruit and vegetable intake and risk of amyotrophic lateral sclerosis in Japan. Neuroepidemiology. 2009;32(4):251–6.CrossRefPubMedGoogle Scholar
  66. 66.
    Okamoto K. Dietary patterns and risk of amyotrophic lateral Screlosis: a case-control study in Japan. J Neurol Epidemiol. 2017. 1–6.Google Scholar

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© Springer Nature Singapore Pte Ltd. 2019

Authors and Affiliations

  1. 1.Department of Public Health and EpidemiologyAichi Prefectural College School of Nursing and HealthNagoyaJapan

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