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Pathology and Cell-Based Therapy of Parkinson’s Disease

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Pathology, Prevention and Therapeutics of Neurodegenerative Disease

Abstract

Parkinson’s disease (PD) comprises an age-related and the second most common disorders which is characterized by progressive motor symptoms such as bradykinesia, rigidity, akinesia, abnormal posture, and resting tremor. The pathology of PD involves the loss of dopaminergic (DA) neurons from the substantia nigra and the production α-synuclein-containing Lewy bodies and Lewy neurites. Current pharmacological treatments for PD target early symptoms by supplying dopamine precursors. These treatments regrettably have long-term side-effects, whereas stem cells-based therapies demonstrate safety and efficiency in preclinical studies through enhancement of dopamine uptake and motor symptoms. Therefore, stem cell transplantation shows great promise as a method to replace lost DA neurons; and for acquiring a better understanding of these neurodegenerative diseases mechanisms. In this review, we discuss recent preclinical studies of stem cell-based therapy for PD and important areas of future research.

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Acknowledgement

This work was carried out with the support of “Cooperative Research Program for Agriculture Science & Technology Development (Project No.PJ011792032017)” Rural Development Administration, Republic of Korea. This research was syupported by the Bio & Medical Technology Development Program of the NRF funded by the Korean gorverment, MSIP (NRF-2016M3A9B6900776).

Conflicts of Interest: The authors declare that they have no competing interests.

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  1. So Young Kim and Sung S. Choi contributed equally to this work.

Authors and Affiliations

  1. Department of Medicine, Chungbuk National University, Cheongju, Republic of Korea

    So Young Kim & Sang Hoon Cha

  2. Research Institute, eBiogen Inc, Seoul, Republic of Korea

    Sung S. Choi & Hong J. Lee

  3. School of Life Sciences and Biotechnology, BK21 Plus KNU Creative BioResearch Group, College of Natural Sciences, Kyungpook National University, Daegu, Republic of Korea

    Dong-Seok Lee

  4. Animal Biotechnology Division, National Institute of Animal Science, RDA, Wanju-gun, Republic of Korea

    Seung Hoon Lee

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  1. Toxicology and Experimental Medicine Division, CSIR-Central Drug Research Institute, Lucknow, India

    Sarika Singh

  2. Department of Surgery, Samuel Oschin Comprehensive Cancer Institute, Cedar Sinai Medical Center, Los Angeles, CA, USA

    Neeraj Joshi

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Kim, S.Y., Choi, S.S., Lee, DS., Lee, S.H., Cha, S.H., Lee, H.J. (2019). Pathology and Cell-Based Therapy of Parkinson’s Disease. In: Singh, S., Joshi, N. (eds) Pathology, Prevention and Therapeutics of Neurodegenerative Disease. Springer, Singapore. https://doi.org/10.1007/978-981-13-0944-1_3

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