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Proteomics of Neurodegenerative Disorders of the Eye

  • Kim Ramasamy
  • Krishnadas Ramasamy
  • Dharmalingam Kuppamuthu
  • Jeya Maheshwari JayapalEmail author
Chapter
Part of the Essentials in Ophthalmology book series (ESSENTIALS)

Abstract

Neurodegenerative eye diseases refer to those ocular conditions where the retina is affected and include pathologies such as diabetic retinopathy, age-related macular degeneration, and glaucoma. All these three diseases are the leading causes of irreversible blindness. Although they affect different parts of the retina, the death of retinal cells that is responsible for vision loss is the common unifying factor of the three conditions. These diseases are generally multifactorial, relatively asymptomatic, and progressive. Proteomics of the tissues and fluids of the posterior compartment of the eye has advanced our understanding on the pathological mechanisms underlying all three conditions. These studies have also contributed to the identification of candidate biomarkers that upon validation would be helpful in the early diagnosis of these diseases.

Keywords

Neurodegeneration Age-related macular degeneration Diabetic retinopathy Glaucoma Proteomics 

Notes

Compliance with Ethical Requirements

R. Kim, R. Krishnadas, K. Dharmalingam, and J. Jeya Maheshwari declare that they have no conflict of interest.

No human or animal studies were performed by the authors for this article.

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Copyright information

© Springer Nature Singapore Pte Ltd. 2019

Authors and Affiliations

  • Kim Ramasamy
    • 1
  • Krishnadas Ramasamy
    • 2
  • Dharmalingam Kuppamuthu
    • 3
  • Jeya Maheshwari Jayapal
    • 3
    Email author
  1. 1.Retina-Vitreous ServicesAravind Eye HospitalMaduraiIndia
  2. 2.Glaucoma ServicesAravind Eye HospitalMaduraiIndia
  3. 3.Department of ProteomicsAravind Medical Research FoundationMaduraiIndia

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