Understanding the Connect of Quorum Sensing and CRISPR-Cas System: Potential Role in Biotechnological Applications

  • Anoop Singh
  • Mohita Gaur
  • Richa Misra


Quorum sensing is employed by bacteria to control gene expression, by communicating through signals, necessary to confer advantageous traits in a community. We now understand that to counter susceptibility to phages in communities, bacteria evolved specialized adaptive immune system called CRISPR-Cas (clustered regularly interspaced short palindromic repeats and CRISPR-associated proteins) system that may use quorum sensing for its regulation. As a countermeasure, phages have also evolved diverse mechanisms to evade the defense strategies. The chapter discusses the dynamics of this co-evolutionary war, understanding of which will help pave way for many biotechnological applications. An important aspect includes refining tools such as quorum-sensing inhibition and phage therapy that are utilized to control many biofilm-forming bacterial infections.


Quorum sensing CRISPR-CAS system Biotechnology 



We sincerely acknowledge the support and guidance provided by Prof. Yogendra Singh, Department of Zoology, University of Delhi, for this work and Dr. Anupam Kumar Mondal, CSIR-IGIB, India for insights into the field of CRISPR biology.


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Copyright information

© Springer Nature Singapore Pte Ltd. 2018

Authors and Affiliations

  • Anoop Singh
    • 1
  • Mohita Gaur
    • 1
  • Richa Misra
    • 1
    • 2
  1. 1.Department of ZoologyUniversity of DelhiDelhiIndia
  2. 2.Department of Zoology, Sri Venkateswara CollegeUniversity of DelhiDelhiIndia

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