Drosophila as a Model to Gain Insight into the Role of lncRNAs in Neurological Disorders

  • Luca Lo Piccolo
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1076)


It is now clear that the majority of transcription in humans results in the production of long non-protein-coding RNAs (lncRNAs) with a variable length spanning from 200 bp up to several kilobases. To date, we have a limited understanding of the lncRNA function, but a huge number of evidences have suggested that lncRNAs represent an outstanding asset for cells. In particular, temporal and spatial expression of lncRNAs appears to be important for proper neurological functioning. Stunningly, abnormal lncRNA function has been found as being critical for the onset of neurological disorders. This chapter focus on the lncRNAs with a role in diseases affecting the central nervous system with particular regard for the lncRNAs causing those neurodegenerative diseases that exhibit dementia and/or motor dysfunctions. A specific section will be dedicated to the human neuronal lncRNAs that have been modelled in Drosophila. Finally, even if only few examples have been reported so far, an overview of the Drosophila lncRNAs with neurological functions will be also included in this chapter.


lncRNAs Neurological disorders Dementia Motor system disorders Drosophila RNA processing hnRNPs Toxic aggregates 


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Copyright information

© Springer Nature Singapore Pte Ltd. 2018

Authors and Affiliations

  • Luca Lo Piccolo
    • 1
  1. 1.Department of NeurotherapeuticsOsaka University Graduate School of Medicine 2-2 YamadaokaSuita OsakaJapan

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