Advertisement

Neuropharmacology of Valeriana Genus

  • Amritpal Singh Saroya
  • Jaswinder Singh
Chapter

Abstract

Garden valerian and garden heliotrope are the common name for this species. The plant is native to certain parts of Asia and Europe and a member of Valerianaceae. However, it has been introduced into North America. It is worthwhile to note that the amino acid, valine, has been named after V. officinalis (Fig. 19.1).

References

  1. Becker A, Felgentreff F, Schröder H, Meier B, Brattström A. The anxiolytic effects of a valerian extract is based on valerenic acid. BMC Complement Altern Med. 2014;14:267.CrossRefPubMedPubMedCentralGoogle Scholar
  2. Benke D, Barberis A, Kopp S, Altmann KH, Schubiger M, Vogt KE, Rudolph U, Möhler H. GABA A receptors as in vivo substrate for the anxiolytic action of valerenic acid, a major constituent of valerian root extracts. Neuropharmacology. 2009;56:174–81.CrossRefPubMedGoogle Scholar
  3. Boeters U. Treatment of control disorders of the autonomic nervous system with valepotriate (Valmane). Munch Med Wochenschr. 1969;111:1873–6.PubMedGoogle Scholar
  4. Castillo P, Zamilpa A, Márquez J, Hernández G, Lara M, Alvarez L. Comparative study of differentiation levels and valepotriate content of in vitro cultures and regenerated and wild plants of Valeriana edulis ssp. procera. J Nat Prod. 2002;65:573–5.CrossRefPubMedGoogle Scholar
  5. Cavadas C, Araújo I, Cotrim MD, Amaral T, Cunha AP, Macedo T, Ribeiro CF. In vitro study on the interaction of Valeriana officinalis L. extracts and their amino acids on GABAA receptor in rat brain. Arzneimittelforschung. 1995;45:753–5.PubMedGoogle Scholar
  6. Del Valle-Mojica LM, Ortíz JG. Anxiolytic properties of Valeriana officinalis in the zebrafish: a possible role for metabotropic glutamate receptors. Planta Med. 2012;78:1719–24.CrossRefPubMedGoogle Scholar
  7. Dominguez RA, Bravo-Valverde RL, Kaplowitz BR, Cott JM. Valerian as a hypnotic for Hispanic patients. Cultur Divers Ethnic Minor Psychol. 2000;6:84–92.CrossRefPubMedGoogle Scholar
  8. Donath F, Quispe S, Diefenbach K, Maurer A, Fietze I, Roots I. Critical evaluation of the effect of valerian extract on sleep structure and sleep quality. Pharmacopsychiatry. 2000;33:47–53.CrossRefPubMedGoogle Scholar
  9. Dunaev VV, Trzhetsinskii SD, Tishkin VS, Fursa NS, Linenko VI. Biological activity of the sum of the valepotriates isolated from Valeriana alliariifolia. Farmakol Toksikol. 1987;50:33–7.PubMedGoogle Scholar
  10. Dymchenko EI. Therapeutic dose of valerian tincture. Vrach Delo. 1969;7:141–2.PubMedGoogle Scholar
  11. Felgentreff F, Becker A, Meier B, Brattström A. Valerian extract characterized by high valerenic acid and low acetoxy valerenic acid contents demonstrates anxiolytic activity. Phytomedicine. 2012;19:1216–22.CrossRefPubMedGoogle Scholar
  12. Francis AJ, Dempster RJ. Effect of valerian, Valeriana edulis, on sleep difficulties in children with intellectual deficits: randomised trial. Phytomedicine. 2002;9:273–9.CrossRefPubMedGoogle Scholar
  13. Haas LF. Neurological stamp. Valeriana officinalis (garden heliotrope). J Neurol Neurosurg Psychiatry. 1996;60:255.CrossRefPubMedPubMedCentralGoogle Scholar
  14. Hassani S, Alipour A, Darvishi Khezri H, Firouzian A, Emami Zeydi A, Gholipour Baradari A, Ghafari R, Habibi WA, Tahmasebi H, Alipour F, Ebrahim Zadeh P. Can Valeriana officinalis root extract prevent early postoperative cognitive dysfunction after CABG surgery? A randomized, double-blind, placebo-controlled trial. Psychopharmacology. 2015;232:843–50.CrossRefPubMedGoogle Scholar
  15. Hölzl J, Koch U. The compounds of Valeriana alliariifolia. Planta Med. 1984;50:458.CrossRefPubMedGoogle Scholar
  16. Kieswetter R, Muller M. The sedative effect of valerian root. Pharmazie. 1958;13:777–81.Google Scholar
  17. Liu XG, Gao PY, Wang GS, Song SJ, Li LZ, Li X, Yao XS, Zhang ZX. In vivo antidepressant activity of sesquiterpenes from the roots of Valeriana fauriei Briq. Fitoterapia. 2012;83:599–603.CrossRefPubMedGoogle Scholar
  18. Malva JO, Santos S, Macedo T. Neuroprotective properties of Valeriana officinalis extracts. Neurotox Res. 2004;6:131–40.CrossRefPubMedGoogle Scholar
  19. Manson JS. The therapeutic value of valerian. Br Med J. 1928;10:842.CrossRefGoogle Scholar
  20. Müller LG, Salles LA, Stein AC, Betti AH, Sakamoto S, Cassel E, Vargas RF, von Poser GL, Rates SM. Antidepressant-like effect of Valeriana glechomifolia Meyer (Valerianaceae) in mice. Prog Neuro-Psychopharmacol Biol Psychiatry. 2012;36:101–9.CrossRefGoogle Scholar
  21. Müller LG, Borsoi M, Stolz ED, Herzfeldt V, Viana AF, Ravazzolo AP, Rates SM. Diene Valepotriates from Valeriana glechomifolia prevent lipopolysaccharide-induced sickness and depressive-like behaviour in mice. Evid Based Complement Alternat Med. 2015;2015:145914.CrossRefPubMedPubMedCentralGoogle Scholar
  22. Neamati A, Chaman F, Hosseini M, Boskabady MH. The effects of Valeriana officinalis L. hydro-alcoholic extract on depression like behaviour in ovalbumin sensitized rats. J Pharm Bioallied Sci. 2014;6:97–103.PubMedPubMedCentralGoogle Scholar
  23. Oliva I, González-Trujano ME, Arrieta J, Enciso-Rodríguez R, Navarrete A. Neuropharmacological profile of hydro alcohol extract of Valeriana edulis ssp. procera roots in mice. Phytother Res. 2004;18:290–6.CrossRefPubMedGoogle Scholar
  24. Ortiz JG, Nieves-Natal J, Chavez P. Effects of Valeriana officinalis extracts on [3H]flunitrazepam binding, synaptosomal [3H]GABA uptake, and hippocampal [3H]GABA release. Neurochem Res. 1999;24:1373–8.CrossRefPubMedGoogle Scholar
  25. Oshima Y, Matsuoka S, Ohizumi Y. Antidepressant principles of Valeriana fauriei roots. Chem Pharm Bull (Tokyo). 1995;43:169–70.CrossRefGoogle Scholar
  26. Pakseresht S, Boostani H, Sayyah M. Extract of valerian root (Valeriana officinalis L.) vs. placebo in treatment of obsessive-compulsive disorder: a randomized double-blind study. J Complement Integr Med. 2011;8. pii: /j/jcim.2011.8.issue-1/1553-3840.1465/1553-3840.1465.Google Scholar
  27. Peters FM. Autonomic dysfunction and its treatment with valerian. Hippokrates. 1953;24:567–70.PubMedGoogle Scholar
  28. Sahu S, Ray K, Yogendra Kumar MS, Gupta S, Kauser H, Kumar S, Mishra K, Panjwani U. Valeriana wallichii root extract improves sleep quality and modulates brain monoamine level in rats. Phytomedicine. 2012;19:924–9.CrossRefPubMedGoogle Scholar
  29. Salles LA, L Silva A, Rech SB, Zanatta N, von Poser GL. Constituents of Valeriana glechomifolia Meyer. Biochem Syst Ecol. 2000;28:907–10.CrossRefPubMedGoogle Scholar
  30. Schulz H, Stolz C, Müller J. The effect of valerian extract on sleep polygraphy in poor sleepers: a pilot study. Pharmacopsychiatry. 1994;27:147–51.CrossRefPubMedGoogle Scholar
  31. Sridharan S, Mohankumar K, Jeepipalli SP, Sankaramourthy D, Ronsard L, Subramanian K, Thamilarasan M, Raja K, Chandra VK, Sadras SR. Neuroprotective effect of Valeriana wallichii rhizome extract against the neurotoxin MPTP in C57BL/6 mice. Neurotoxicology. 2015;51:172–83.CrossRefPubMedGoogle Scholar
  32. Sudati JH, Fachinetto R, Pereira RP, Boligon AA, Athayde ML, Soares FA, de Vargas Barbosa NB, Rocha JB. In vitro antioxidant activity of Valeriana officinalis against different neurotoxic agents. Neurochem Res. 2009;34:1372–9.CrossRefPubMedGoogle Scholar
  33. Thies PW. Linarin-isovalerianate, a currently unknown flavonoid from Valeriana wallichii D.C. 6. Report on the active substances of Valeriana. Planta Med. 1968;16:363–71.CrossRefPubMedGoogle Scholar
  34. Wasowski C, Marder M, Viola H, Medina JH, Paladini AC. Isolation and identification of 6-methylapigenin, a competitive ligand for the brain GABA(a) receptors, from Valeriana wallichii. Planta Med. 2002;68:934–6.CrossRefPubMedGoogle Scholar
  35. Zhang ZX, Dou DQ, Liu K, Yao XS. Studies on the chemical constituents of Valeriana fauriei Briq. J Asian Nat Prod Res. 2006;8:397–400.CrossRefPubMedGoogle Scholar

Copyright information

© Springer Nature Singapore Pte Ltd. 2018

Authors and Affiliations

  • Amritpal Singh Saroya
    • 1
  • Jaswinder Singh
    • 2
  1. 1.Herbal ConsultantMohaliIndia
  2. 2.Department of PharmacologySri Guru Ram Das Institute of Medical ScienceAmritsarIndia

Personalised recommendations