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Neuropharmacology of Celastrus paniculatus Willd.

  • Amritpal Singh Saroya
  • Jaswinder Singh
Chapter

Abstract

Celastrus paniculatus Willd. syn. C. multiflorus Roxb. (Celastraceae) is a hardy shrub that grows in a wide variety of climates and environments (Krishnamurthy 1993). The plant is native to the Indian continent but is known to grow wildly in Australia, China, Taiwan, Cambodia, Indonesia, Laos, Malaysia, Myanmar, Nepal, Sri Lanka, Thailand and Vietnam as well as in many of the Pacific islands (Singh et al. 1996).

References

  1. Basu NK, Pabrai PR. Chemical investigation of Celastrus paniculatus Willd. J Am Pharm Assoc. 2006;35:272–3.CrossRefGoogle Scholar
  2. Bhanumathy M, Harish MS, Shivaprasad HN, Sushma G. Nootropic activity of Celastrus paniculatus seed. Pharm Biol. 2010;148:324–7.CrossRefGoogle Scholar
  3. Bhattacharjee SK. Hand book of medicinal plants. ed. Shashi Jam Printers. Jaipur; 2000.Google Scholar
  4. Bidwai PP, Wangoo D, Bhullar NK. Effect of Celastrus paniculatus seed extract on the brain of albino rats. J Ethnopharmacol. 1987;21:307–14.CrossRefPubMedGoogle Scholar
  5. Chopra RN. Indigenous drug of India. ed. Dhur UN and Son’s Pvt. Ltd. Culcutta; 1956.Google Scholar
  6. Gattu M, Boss KL, Terry AV, Buccafusco JJ. Reversal of scopolamine-induced deficits in navigational memory performance by the seed oil of Celastrus paniculatus. Pharmacol Biochem Behavior. 1997;57:793–9.CrossRefGoogle Scholar
  7. Godkar P, Gordon RK, Ravindran A, Doctor BP. Celastrus paniculatus seed water soluble extracts protect cultured rat forebrain neuronal cells from hydrogen peroxide-induced oxidative injury. Fitoterapia. 2003;74:658–69.CrossRefPubMedGoogle Scholar
  8. Godkar PB, Gordon RK, Ravindran A, Doctor BP. Celastrus paniculatus seed water soluble extracts protect against glutamate toxicity in neuronal cultures from rat forebrain. J Ethnopharmacol. 2004;93:213–9.CrossRefPubMedGoogle Scholar
  9. Godkar PB, Gordon RK, Ravindran A, Doctor BP. Celastrus paniculatus seed oil and organic extracts attenuate hydrogen peroxide- and glutamate-induced injury in embryonic rat forebrain neuronal cells. Phytomedicine. 2006;13:29–36.CrossRefPubMedGoogle Scholar
  10. Krishnamurthy T. Minor forest products of India. Oxford and IBH. New Delhi: Publishing Co. Pvt. Ltd; 1993.Google Scholar
  11. Nalini K, Karanth KS, Rao A, Aroor AR. Effects of Celastrus paniculatus on passive avoidance performance and biogenic amine turnover in albino rats. J Ethnopharmacol. 1995;47:101–8.CrossRefPubMedGoogle Scholar
  12. Patel DK, Amin KS, Nanavati DD. Chemistry and pharmacology of Celastrus paniculatus Willd. Indian Drugs. 1995;32:566–73.Google Scholar
  13. Praful M, Sushil K. Neuroprotective effect of C. paniculatus seed oil against glutamate-induced toxicity. Planta Med. 2004;21:44–7.Google Scholar
  14. Rajkumar R, Kumar EP, Sudha S, Suresh B. Evaluation of anxiolytic potential of Celastrus oil in rat models of behaviour. Fitoterapia. 2007;78:120–4.CrossRefPubMedGoogle Scholar
  15. Ravishankar B, Shukla VJ. Indian system of medicine: a brief profile. Afr J Trad Compl Alter Med. 2007;4:319–37.CrossRefGoogle Scholar
  16. Sang H, Wang H, Tu Y. New βdihydroagarofuran sesquiterpenoids from Celastrus paniculatus. Mag Reson Chem. 2005;29:650–5.CrossRefGoogle Scholar
  17. Satakopan S, Gaitonde BB. Malkangni. A pharmacognostic study. Indian J Pharmacol. 1960;22:196–9.Google Scholar
  18. Sengupta H, Bhargava N. Chemical investigation of the seed fat of Celastrus paniculatus. J Sci Food Agricul. 2006;21:629–31.Google Scholar
  19. Sheth UK, Vaz A, Deliwala CV, Bellare RA. Behavioural and pharmacological studies of a tranquilising fraction from the oil of Celastrus paniculatus (malkangni oil). Arch Int Pharmacodyn Ther. 1963;144:34–50.PubMedGoogle Scholar
  20. Singh U, Wadhwani AM, Johri BM. Dictionary of economical plants of India. New Delhi: Indian Council of Agricultural Research; 1996.Google Scholar
  21. Yasu LU, Yang S, Zou Z, Chen H, Zhen X, Zhongemei Z, Luo X, Chen H, Lizhen LU. Evoninoate sesquiterpene alkaloids from the stem of Celastrus paniculatus. Heterocycles. 2006;68:1241–7.CrossRefGoogle Scholar

Copyright information

© Springer Nature Singapore Pte Ltd. 2018

Authors and Affiliations

  • Amritpal Singh Saroya
    • 1
  • Jaswinder Singh
    • 2
  1. 1.Herbal ConsultantMohaliIndia
  2. 2.Department of PharmacologySri Guru Ram Das Institute of Medical ScienceAmritsarIndia

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