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Modelling Details for Electric Field Simulations of Deep Brain Stimulation

  • Johannes D. JohanssonEmail author
  • Fabiola Alonso
  • Karin Wårdell
Conference paper
Part of the IFMBE Proceedings book series (IFMBE, volume 68/1)

Abstract

Deep brain stimulation is a well-established technique for symptomatic treatment of e.g. Parkinson’s disease and essential tremor. Computer simulations using the finite element method (FEM) are widely used to estimate the affected area around the DBS electrodes. For the reliability of the simulations, it is important to match used simulation parameters with experimental data. One such parameter is the electric field magnitude threshold EFt required for axon stimulation. Another is the conductivity of the perielectrode space (PES) around the electrode. At the acute stage after surgery the PES will be characterized by an increased conductivity due to inflammation and edema while the later chronic stage will be characterized by a lower conductivity due to gliosis and minor scar formation. In this study, the EFt and the electric conductivity of the PES have been estimated by comparing FEM simulations with clinical studies of activation distance, pulse length and electrode impedance. The resulting estimates are an EFt of 0.2 V/mm at the common pulse width of 60 µs and a chronaxie of 62 µs. Estimated electric conductivities for the PES are 0.14 S/m in the acute stage and 0.05 S/m in the chronic stage, assuming a PES width of 250 µm. These values are thus experimentally justified to use in FEM simulations of DBS.

Keywords

Deep brain stimulation (DBS) Finite element method (FEM) Electric field (EF) 

Notes

Acknowledgements

This work is funded by the Swedish Research Council (Vetenskapsrådet, Dnr. 2016-03564), the Swedish Foundation for Strategic Research (Project BD15-0032), and the Knut and Alice Wallenberg Foundation (Project Seeing Organ Function). The authors declare that they have no conflicts of interest.

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Copyright information

© Springer Nature Singapore Pte Ltd. 2019

Authors and Affiliations

  1. 1.Linköping UniversityLinköpingSweden

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