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Quorum Sensing Interference by Natural Products from Medicinal Plants: Significance in Combating Bacterial Infection

  • Mohammad Shavez Khan
  • Faizan Abul Qais
  • Iqbal Ahmad
Chapter

Abstract

Plant derived natural products and phytocompounds are known for their broad spectrum biological activities and are of great therapeutic value in traditional system of medicine. The role of medicinal plants and phytocompounds in the treatment of various diseases including bacterial infection are widely documented. Anti-infective compounds from medicinal plants may provide new drug leads. Bacterial cell to cell communication has been become attractive target for the development of novel anti-infective measures that do not rely on the use of antibiotics. Targeting Quorum sensing has been emerge as promising strategy to combat bacterial infections as it is unlikely to develop multidrug resistance pathogens since it does not impose any selection pressure. In this review, we have surveyed the recent literature available on plant extracts, essential oils and phytocompounds exhibiting anti-quorum sensing properties. Further, significance of phytocompounds to combat bacterial infections caused by MDR bacteria has been discussed.

Keywords

Anti-QS activity Autoinducer Bacterial cell to cell communication Infectious disease N-acylhomoserine lactone Medicinal plants Phytocompounds 

Abbreviations

AHL

N-Acyl homoserine lactone

AI

Auto Inducer

CF

Cystic Fibrosis

EPS

Extracellular Polymeric Substances

HSL

Homoserine Lactone

MDR

Multi Drug Resistance

MIC

Minimum Inhibitory Concentration

QSI

Quorum Sensing Inhibitors

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Copyright information

© Springer Nature Singapore Pte Ltd. 2018

Authors and Affiliations

  • Mohammad Shavez Khan
    • 1
  • Faizan Abul Qais
    • 1
  • Iqbal Ahmad
    • 1
  1. 1.Department of Agricultural Microbiology, Faculty of Agricultural SciencesAligarh Muslim UniversityAligarhIndia

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