Synergism Between Quorum Sensing Inhibitors and Antibiotics: Combating the Antibiotic Resistance Crisis

  • Sahana Vasudevan
  • Shogan Sugumar Swamy
  • Gurmeet Kaur
  • S. Adline Princy
  • P. BalamuruganEmail author


With the alarming increase in the antibiotic resistance, there is an immediate need for alternative therapeutic strategies to combat this ever-changing bacterial battle. Combinatorial therapies have gained attention owing to their multiple targeted actions. The use of antibiotic is inevitable and antibiotics in combinations have been in use to treat drug resistant infections. Nevertheless, the multidrug resistant strains have found their own mechanisms to surpass such combinatorial treatments. Quorum sensing (QS) inhibition is considered to be the silver lining but is yet to find its way to commercial use. Hence, to combat the antibiotic resistance crisis, the synergy of QSIs and antibiotics is one of the possible revolutionary approaches. In this chapter, we have highlighted the importance and need for the synergy approach with the successful in vitro and in vivo studies that can possibly be extended to the commercial use.


Biofilm Antibiotic Resistance Quorum sensing inhibition Synergy 


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Copyright information

© Springer Nature Singapore Pte Ltd. 2018

Authors and Affiliations

  • Sahana Vasudevan
    • 1
  • Shogan Sugumar Swamy
    • 1
  • Gurmeet Kaur
    • 1
  • S. Adline Princy
    • 1
  • P. Balamurugan
    • 1
    Email author
  1. 1.Quorum Sensing Laboratory, Centre for Research in Infectious Diseases (CRID), School of Chemical and BiotechnologySASTRA Deemed UniversityThanjavurIndia

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