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Asthma Precision

  • Fang Chen
  • Jia-Ying Zhang
  • Hong-Kuan Yang
  • Fang Wang
Chapter
Part of the Translational Bioinformatics book series (TRBIO, volume 12)

Abstract

Asthma is a complex and heterogeneous disease, as the reaction to recommended treatmens varies with each individual, especially for refractory and severe asthma. Cluster analysis has helped us to distinguish the different features of asthma phenotype according to asthma patient population, clinical symptoms and pathophysiological changes, and due to advances of omics sequencing in genomics and proteomics, we can detect asthma biomarkers derived from multiple specimens, accurately and quickly finding the pathogenesis of asthma. These progresses have promoted the personalized therapy of asthma. Many targeted drugs aiming to small molecules that had changed in the process of asthma have already obtained the initial efficacy in clinical trials. In addition, the safety and effectiveness of bronchial thermoplasty have also been affirmed. This article mainly focuses on these selected therapeutic targets therapies.

Keywords

Asthma Personalized therapy Precision medicine Bronchial thermoplasty 

Abbreviations

AAAAI

The American Academy of Allergy, Asthma and Immunology

ACQ

asthma control questionnaire

ADCC

antibody-dependent cell-mediated cytotoxicity

AEC

absolute eosinophil count

AHR

airway hyperreactivity

AQLQ

asthma quality of life questionnaire

ASM

airway smooth muscle

BD

bronchodilator

BHR

bronchial hyperresponsiveness

BMI

body mass index

COPD

chronic obstructive pulmonary disease

CPAP

continuous positive airway pressure

CRP

C-reactive protein

CRTH

chemoattractant receptor–homologous

CXCR2

C-X-C chemokine receptor type2

ED

emergency department

FDA

Food and Drug Administration

FeNO

fractional exhaled nitric oxide

FEV1

forced expired volume in 1 s

GINA

Global Initiative for Asthma

HR

hazard ratio

ICS/CS

inhaled corticosteroids/ corticosteroids

IL-13

interleukin 13

Il-17

interleukin 17

IL-4

interleukin 4

Il-5

interleukin 5

ILC2

group 2 innate lymphoid cells

LABA

long-acting β-agonists

MCh

methacholine

OCS

oral corticosteroids

PEF

peak expiratory flow

PGD2

prostaglandin D2

PM

precision medicine

QALY

quality-adjusted life year

RCT

randomized controlled trial

TNF-α

tumor necrosis factor-α

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Copyright information

© Springer Nature Singapore Pte Ltd. 2018

Authors and Affiliations

  • Fang Chen
    • 1
  • Jia-Ying Zhang
    • 2
  • Hong-Kuan Yang
    • 2
  • Fang Wang
    • 2
  1. 1.The First Affiliated Hospital of Zhejiang Chinese Medical UniversityHangzhouChina
  2. 2.First Clinical Medical College of Zhejiang Chinese Medical UniversityHangzhouChina

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