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Anticancer Plant Molecules for the Improvement of Immune System

  • Om Prakash
  • Pratibha Preeti Maurya
  • Ajeet
Chapter

Abstract

In the past few years, small bioactive molecules of plant origin have become the centre of elevated curiosity among the drug designers. Drug developers are focused for understanding the mechanisms of action and potential role of plant metabolites in the prevention and treatment of multiple diseases including cancer. There are large groups of secondary plant metabolites, which provide numerous potentially health-beneficial biological activities through our diet. In addition to health benefits, many other biological functions are reported in the literature for plant molecules as inhibition of cancer cell proliferation and stimulation of immune function. Many of the structurally diverse plant metabolites stimulate immune cell activity and have great potential as diet-derived immune-modulator chemopreventive agents. They may even serve as lead structures for the development of novel/upgraded drugs for the treatment of both malignant and viral diseases. This chapter has been organised to present extensive description about plants as well as their potential molecules, which are majorly notified for the anticancer activity as well as improvement of immune system.

Keywords

Anticancer Antiproliferative Immune Immunomodulatory Metabolite 

References

  1. Agrawal J, Pal A (2013) Nyctanthes arbor-tristis Linn-a critical ethnopharmacological review. J Ethnopharmacol 146:645–658CrossRefPubMedGoogle Scholar
  2. Amirghofran Z, Malek-hosseini S, Gholmoghaddam H, Kalalinia F (2011) Inhibition of tumor cells growth and stimulation of lymphocytes by Euphorbia species. Immunopharmacol Immunotoxicol 33:34–42CrossRefPubMedGoogle Scholar
  3. Arreola R, Quintero-Fabian S, Lopez-Roa RI, Flores-Gutierrez EO, Reyes-Grajeda JP, Carrera-Quintanar L, Ortuño-Sahagún D (2015) Immunomodulation and anti-inflammatory effects of garlic compounds. J Immunol Res 2015:401630.  https://doi.org/10.1155/2015/401630 CrossRefPubMedPubMedCentralGoogle Scholar
  4. Ayeka PA, Bian Y, Mwitari PG, Chu X, Zhang Y, Uzayisenga R, Otachi EO (2016) Immunomodulatory and anticancer potential of Gan cao (Glycyrrhiza uralensis Fisch.) polysaccharides by CT-26 colon carcinoma cell growth inhibition and cytokine IL-7 upregulation in vitro. BMC Compl Altern Med 16:206.  https://doi.org/10.1186/s12906-016-1171-4 CrossRefGoogle Scholar
  5. Bala M, Pratap K, Verma PK, Singh B, Padwad Y (2015) Validation of ethnomedicinal potential of Tinospora cordifolia for anticancer and immunomodulatory activities and quantification of bioactive molecules by HPTLC. J Ethnopharmacol 175:131–137.  https://doi.org/10.1016/j.jep.2015.08.001 CrossRefPubMedGoogle Scholar
  6. Baraya YU, Wong KK, Yaacob NS (2017) The immunomodulatory potential of selected bioactive plant-based compounds in breast cancer: a review. Anti Cancer Agents Med Chem 17:770–783CrossRefGoogle Scholar
  7. Bharati AC, Sahu AN (2012) Ethnobotany, phytochemistry and pharmacology of Biophytum sensitivum DC. Pharmacol Rev 6:68–73CrossRefGoogle Scholar
  8. Bronikowska J, Szliszka E, Jaworska D, Czuba ZP, Krol W (2012) The coumarin psoralidin enhances anticancer effect of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL). Molecules 17:6449–6464CrossRefPubMedGoogle Scholar
  9. Burkard M, Leischner C, Lauer UM, Busch C, Venturelli S, Frank J (2017) Dietary flavonoids and modulation of natural killer cells: implications in malignant and viral diseases. J Nutr Biochem 46:1–12CrossRefPubMedGoogle Scholar
  10. Chang R (2002) Bioactive polysaccharides from traditional Chinese medicine herbs as anticancer adjuvants. J Altern Compl Med 8:559–565CrossRefGoogle Scholar
  11. Chen Y, Tang YM, Yu SL, Han YW, Kou JP, Liu BL, Yu BY (2015) Advances in the pharmacological activities and mechanisms of diosgenin. Chin J Nat Med 13:578–587PubMedGoogle Scholar
  12. Chhatre S, Nesari T, Somani G, Kanchan D, Sathaye S (2014) Phytopharmacological overview of Tribulus terrestris. Pharmacol Rev 8:45–51CrossRefGoogle Scholar
  13. Costa G, Rocca R, Moraca F, Talarico C, Romeo I, Ortuso F, Alcaro S, Artese A (2016) A comparative docking strategy to identify polyphenolic derivatives as promising antineoplastic binders of G-quadruplex DNA c-myc and bcl-2 sequences. Mol Inform 35:391–402CrossRefPubMedGoogle Scholar
  14. Dai X, Liu J, Nian Y, Qiu MH, Luo Y, Zhang J (2017) A novel cycloartane triterpenoid from Cimicifuga induces apoptotic and autophagic cell death in human colon cancer HT-29 cells. Oncol Rep 37:2079–2086CrossRefPubMedGoogle Scholar
  15. Dijsselbloem N, Vanden Berghe W, De Naeyer A, Haegeman G (2004) Soy isoflavone phyto-pharmaceuticals in interleukin-6 affections. Multi-purpose nutraceuticals at the crossroad of hormone replacement, anti-cancer and anti-inflammatory therapy. Biochem Pharmacol 68:1171–1185CrossRefPubMedGoogle Scholar
  16. Fantini M, Benvenuto M, Masuelli L, Frajese GV, Tresoldi I, Modesti A, Bei R (2015) In vitro and in vivo antitumoral effects of combinations of polyphenols, or polyphenols and anticancer drugs: perspectives on cancer treatment. Int J Mol Sci 16:9236–9282CrossRefPubMedPubMedCentralGoogle Scholar
  17. Galili U, Anaraki F (1995) Alpha-galactosyl (Galalpha1-3Galbeta1-4GlcNAc-R) epitopes on human cells: synthesis of the epitope on human red cells by recombinant primate alpha1,3 galactosyltransferase expressed in E. coli. Glycobiology 5:775–782CrossRefPubMedGoogle Scholar
  18. Georgaki S, Skopeliti M, Tsiatas M, Nicolaou KA, Ioannou K, Husband A, Bamias A, Dimopoulos MA, Constantinou AI, Tsitsilonis OE (2009) Phenoxodiol, an anticancer isoflavene, induces immunomodulatory effects in vitro and in vivo. J Cell Mol Med 13:3929–3938CrossRefPubMedPubMedCentralGoogle Scholar
  19. Gold-Smith F, Fernandez A, Bishop K (2016) Mangiferin and cancer: mechanisms of action. Forum Nutr 8:E396.  https://doi.org/10.3390/nu8070396 CrossRefGoogle Scholar
  20. Gostner JM, Schroecksnadel S, Jenny M, Klein A, Ueberall F, Schennach H, Fuchs D (2015) Coffee extracts suppress tryptophan breakdown in mitogen-stimulated peripheral blood mononuclear cells. J Am Coll Nutr 34:212–223CrossRefPubMedGoogle Scholar
  21. Grover A, Shandilya A, Punetha A, Bisaria VS, Sundar D (2010) Inhibition of the NEMO/IKKbeta association complex formation, a novel mechanism associated with the NF-kappaB activation suppression by Withania somnifera’s key metabolite withaferin A. BMC Genomics 11:S25.  https://doi.org/10.1186/1471-2164-11-S4-S25 CrossRefPubMedPubMedCentralGoogle Scholar
  22. Hao DC, Gu X, Xiao P (2017) Anemone medicinal plants: ethnopharmacology, phytochemistry and biology. Acta Pharm Sin B 7:146–158CrossRefPubMedPubMedCentralGoogle Scholar
  23. Hernandez-Ledesma B, Hsieh CC (2017) Chemopreventive role of food-derived proteins and peptides: a review. Crit Rev Food Sci Nutr 57:2358–2376CrossRefPubMedGoogle Scholar
  24. Kokotkiewicz A, Jaremicz Z, Luczkiewicz M (2010) Aronia plants: a review of traditional use, biological activities, and perspectives for modern medicine. J Med Food 13:255–269CrossRefPubMedGoogle Scholar
  25. Lai X, Pei Q, Song X, Zhou X, Yin Z, Jia R, Zou Y, Li L, Yue G, Liang X, Yin L, Lv C, Jing B (2016) The enhancement of immune function and activation of NF-kappaB by resveratrol-treatment in immunosuppressive mice. Int Immunopharmacol 33:42–47CrossRefPubMedGoogle Scholar
  26. Li Y, Hu Y, Shi S, Jiang L (2014) Evaluation of antioxidant and immuno-enhancing activities of purslane polysaccharides in gastric cancer rats. Int J Biol Macromol 68:113–116CrossRefPubMedGoogle Scholar
  27. Limtrakul P, Yodkeeree S, Pitchakarn P, Punfa W (2015) Suppression of inflammatory responses by black rice extract in RAW 264.7 macrophage cells via down regulation of NF-kB and AP-1 signaling pathways. Asian Pac J Can Prevent 16:4277–4283CrossRefGoogle Scholar
  28. Liu CC, Yang H, Zhang LL, Zhang Q, Chen B, Wang Y (2014) Biotoxins for cancer therapy. Asian Pac J Can Prevent 15:4753–4758CrossRefGoogle Scholar
  29. Mace TA, King SA, Ameen Z, Elnaggar O, Young G, Riedl KM, Schwartz SJ, Clinton SK, Knobloch TJ, Weghorst CM, Lesinski GB (2014) Bioactive compounds or metabolites from black raspberries modulate T lymphocyte proliferation, myeloid cell differentiation and Jak/STAT signaling. Cancer Immunol Immunother 63:889–900CrossRefPubMedPubMedCentralGoogle Scholar
  30. Mantle D, Lennard TW, Pickering AT (2000) Therapeutic applications of medicinal plants in the treatment of breast cancer: a review of their pharmacology, efficacy and tolerability. Adverse Drug React Toxicol Rev 19:223–240PubMedGoogle Scholar
  31. Medrano G, Dolan MC, Stephens NT, McMickle A, Erf G, Radin D, Cramer CL (2010) Efficient plant-based production of chicken interleukin-12 yields a strong immunostimulatory cytokine. J Interf Cytokine Res 30:143–154CrossRefGoogle Scholar
  32. Meeran SM, Katiyar S, Elmets CA, Katiyar SK (2006) Silymarin inhibits UV radiation-induced immunosuppression through augmentation of interleukin-12 in mice. Mol Cancer Therap 5:1660–1668CrossRefGoogle Scholar
  33. Miles SL, McFarland M, Niles RM (2014) Molecular and physiological actions of quercetin: need for clinical trials to assess its benefits in human disease. Nutr Rev 72:720–734CrossRefPubMedGoogle Scholar
  34. Multhoff G, Radons J (2012) Radiation, inflammation, and immune responses in cancer. Front Oncol 2:58.  https://doi.org/10.3389/fonc.2012.00058 CrossRefPubMedPubMedCentralGoogle Scholar
  35. Naik R, Harmalkar DS, Xu X, Jang K, Lee K (2015) Bioactive benzofuran derivatives: moracins A-Z in medicinal chemistry. Eur J Med Chem 90:379–393CrossRefPubMedGoogle Scholar
  36. Ng TB, Liu J, Wong JH, Ye X, Wing Sze SC, Tong Y, Zhang KY (2012) Review of research on Dendrobium, a prized folk medicine. Appl Microbiol Biotechnol 93:1795–1803CrossRefPubMedGoogle Scholar
  37. Nowicky JW, Staniszewski A, Zbroja-Sontag W, Slesak B, Nowicky W, Hiesmayr W (1991) Evaluation of thiophosphoric acid alkaloid derivatives from Chelidonium majus L. (“Ukrain”) as an immunostimulant in patients with various carcinomas. Drugs Exp Clin Res 17:139–143PubMedPubMedCentralGoogle Scholar
  38. Nunez Selles AJ, Daglia M, Rastrelli L (2016) The potential role of mangiferin in cancer treatment through its immunomodulatory, anti-angiogenic, apoptopic, and gene regulatory effects. Biofactors 42:475–491CrossRefPubMedPubMedCentralGoogle Scholar
  39. Panthong S, Ruangnoo S, Thongdeeying P, Sriwanthana B, Itharat A (2014) Immunomodulatory activity of Dioscorea membranacea Pierre rhizomes and of its main active constituent Dioscorealide B. BMC Compl Alternat Med 14:403CrossRefGoogle Scholar
  40. Pardo Andreu GL, Maurmann N, Reolon GK, de Farias CB, Schwartsmann G, Delgado R, Roesler R (2010) Mangiferin, a naturally occurring glucoxilxanthone improves long-term object recognition memory in rats. Eur J Pharmacol 635:124–128CrossRefPubMedGoogle Scholar
  41. Patil KS, Bhalsing SR (2016) Ethnomedicinal uses, phytochemistry and pharmacological properties of the genus Boerhavia. J Ethnopharmacol 182:200–220CrossRefPubMedGoogle Scholar
  42. Patil D, Gautam M, Gairola S, Jadhav S, Patwardhan B (2014) HPLC/tandem mass spectrometric studies on steroidal saponins: an example of quantitative determination of Shatavarin IV from dietary supplements containing Asparagus racemosus. J AOAC Intl 97:1497–1502CrossRefGoogle Scholar
  43. Perentesis JP, Miller SP, Bodley JW (1992) Protein toxin inhibitors of protein synthesis. Biofactors 3:173–184PubMedGoogle Scholar
  44. Petrovsky N, Cooper PD (2015) Advax, a novel microcrystalline polysaccharide particle engineered from delta inulin, provides robust adjuvant potency together with tolerability and safety. Vaccine 33:5920–5926CrossRefPubMedPubMedCentralGoogle Scholar
  45. Piotrowski J, Jedrzejewski T, Kozak W (2015) Immunomodulatory and antitumor properties of polysaccharide peptide (PSP). Post Hig Med Doswiad 69:91–97CrossRefGoogle Scholar
  46. Pribis P, Shukitt-Hale B (2014) Cognition: the new frontier for nuts and berries. Am J Clin Nutr 1001:S347–S352CrossRefGoogle Scholar
  47. Rastogi S, Pandey MM, Kumar Singh Rawat A (2015) Medicinal plants of the genus Betula-traditional uses and a phytochemical-pharmacological review. J Ethnopharmacol 159:62–83CrossRefPubMedGoogle Scholar
  48. Rasul A, Zhao BJ, Liu J, Liu B, Sun JX, Li J, Li XM (2014) Molecular mechanisms of casticin action: an update on its antitumor functions. Asian Pac J Can Prevent 15:9049–9058CrossRefGoogle Scholar
  49. Ravindranath MH, Muthugounder S, Presser N, Viswanathan S (2004) Anticancer therapeutic potential of soy isoflavone, genistein. Adv Exp Med Biol 546:121–165CrossRefPubMedGoogle Scholar
  50. Razali FN, Sinniah SK, Hussin H, Zainal Abidin N, Shuib AS (2016) Tumor suppression effect of Solanum nigrum polysaccharide fraction on breast cancer via immunomodulation. Int J Biol Macromol 92:185–193CrossRefPubMedGoogle Scholar
  51. Reina E, Al-Shibani N, Allam E, Gregson KS, Kowolik M, Windsor LJ (2013) The effects of Plantago major on the activation of the neutrophil respiratory burst. J Trad Compl Med 3:268–272CrossRefGoogle Scholar
  52. Saha S, Sadhukhan P, Sil PC (2016) Mangiferin: a xanthonoid with multipotent anti-inflammatory potential. Biofactors 42:459–474CrossRefPubMedGoogle Scholar
  53. Semwal DK, Semwal RB, Vermaak I, Viljoen A (2014) From arrow poison to herbal medicine-the ethnobotanical, phytochemical and pharmacological significance of Cissampelos (Menispermaceae). J Ethnopharmacol 155:1011–1028CrossRefPubMedGoogle Scholar
  54. Shareef M, Ashraf MA, Sarfraz M (2016) Natural cures for breast cancer treatment. Saudi Pharma J 24:233–3403CrossRefGoogle Scholar
  55. Sharma H, Garg M (2015) A review of traditional use, phytoconstituents and biological activities of Himalayan yew, Taxus wallichiana. J Integr Med 13:80–90CrossRefPubMedGoogle Scholar
  56. Shen CY, Yang L, Jiang JG, Zheng CY, Zhu W (2017) Immune enhancement effects and extraction optimization of polysaccharides from Citrus aurantium L. var. amara. Eng Food Function 8:796–807CrossRefGoogle Scholar
  57. Singh S, Awasthi M, Pandey VP, Dwivedi UN (2017) Lipoxygenase directed anti-inflammatory and anti-cancerous secondary metabolites: ADMET-based screening, molecular docking and dynamics simulation. J Biomol Struct Dyn 35:657–668CrossRefPubMedGoogle Scholar
  58. Siveen KS, Kuttan G (2012) Modulation of humoral immune responses and inhibition of proinflammatory cytokines and nitric oxide production by 10-methoxycanthin-6-one. Immunopharmacol Immunotoxicol 34:116–125CrossRefPubMedGoogle Scholar
  59. Suman S, Shukla Y (2016) Diallyl sulfide and its role in chronic diseases prevention. Adv Exp Med Biol 929:127–144CrossRefPubMedGoogle Scholar
  60. Szliszka E, Czuba ZP, Sedek L, Paradysz A, Krol W (2011) Enhanced TRAIL-mediated apoptosis in prostate cancer cells by the bioactive compounds neobavaisoflavone and psoralidin isolated from Psoralea corylifolia. Pharmacol Rep 63:139–148CrossRefPubMedGoogle Scholar
  61. Varma A, Padh H, Shrivastava N (2011) Andrographolide: a new plant-derived antineoplastic entity on horizon. Evidence-Based Compl Altern Med 2011:815390.  https://doi.org/10.1093/ecam/nep135 CrossRefGoogle Scholar
  62. Viswanathan V, Phadatare AG, Mukne A (2014) Antimycobacterial and antibacterial activity of Allium sativum bulbs. Indian J Pharm Sci 76:256–261PubMedPubMedCentralGoogle Scholar
  63. Yoo K, Porter JR (1993) Immunoassay of podophyllotoxin. J Nat Prod 56:715–721CrossRefPubMedGoogle Scholar
  64. You Guo C, Zong Ji S, Xiao Ping C (2009) Evaluation of free radicals scavenging and immunity-modulatory activities of purslane polysaccharides. Int J Biol Macromol 45:448–452CrossRefGoogle Scholar
  65. Zhang ZR, Leung WN, Cheung HY, Chan CW (2015) Osthole: a review on its bioactivities, pharmacological properties, and potential as alternative medicine. Evidence-Based Compl Altern Med 2015:919616.  https://doi.org/10.1155/2015/919616 CrossRefGoogle Scholar
  66. Zou TB, Xia EQ, He TP, Huang MY, Jia Q, Li HW (2014) Ultrasound-assisted extraction of Mangiferin from mango (Mangifera indica L.) leaves using response surface methodology. Molecules 19:1411–1421CrossRefPubMedGoogle Scholar

Copyright information

© Springer Nature Singapore Pte Ltd. 2018

Authors and Affiliations

  • Om Prakash
    • 1
  • Pratibha Preeti Maurya
    • 2
  • Ajeet
    • 3
  1. 1.Department of BiochemistryUniversity of LucknowLucknowIndia
  2. 2.Computational Biology for Biochemical ExperimentsLucknowIndia
  3. 3.Department of PharmacyVishveshwarya Group of InstitutionsGreater NoidaIndia

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