Anticancer Properties of Natural Compounds on Prostate Cancer

  • Priyadarshini
  • Abhishek Negi


Natural products contain a rich source of compounds that has several applications in the field of medicine and biology. A number of herbal plants have shown promising results, and several herbs and minerals used in ancient medicine have led to the identification of numerous medicinal plant compounds with anticancer effects like antiproliferative, pro-apoptotic, anti-metastatic, and anti-angiogenic that have been shown in in vitro experiments or animal studies. But only a small number of them have been tested in cancerous patients, and so limited evidence exists for their clinical effectiveness. A number of common herbal preparation like curcumin, resveratrol and Viscum album, green tea, pomegranate extract, grapes extract, and many new compounds with diverse structure, more selective, and less toxic activity have been isolated from plants that are considered potent anticancer agents. Several herbal preparations containing multiple phytochemicals have been prepared like PC-SPES, with the belief that these would work better than a individual phytochemical. Cancer being associated with high mortality rate can be cured successfully with natural products which have less side effects than the synthetic drugs. The aim of this chapter is to provide an overview on some of the herbal plants and their compounds, which have been associated with cancer cases and undergone a prospective clinical investigation for identifying anticancer properties either in vivo or in vitro.


Anticancer agents Chemotherapy Natural products Prostate cancer 


  1. Aggarwal S, Ichikawa H, Takada Y, Sandur S, Shishodia S, Aggarwal B (2005) Curcumin (Diferuloylmethane) down regulates expression of cell proliferation, antiapoptotic and metastatic gene products through suppression of IB kinase and AKT activation. Mol Pharmacol 69:195–206PubMedPubMedCentralGoogle Scholar
  2. Akiyama T, Ishida J, Nakagawa S, Ogawara H, Watanabe S, Itoh N (1987) Genistein, a specific inhibitor of tyrosine-specific protein kinases. J Biol Chem 262:5592–5595PubMedPubMedCentralGoogle Scholar
  3. Albrecht M, Jiang W, Kumi-Diaka J, Lansky E, Gommersall L, Patel A, Mansel R, Neeman I, Geldof A, Campbell M (2004) Pomegranate extracts potently suppress proliferation, xenograft growth, and invasion of human prostate cancer cells. J Med Food 7:274–283PubMedCrossRefPubMedCentralGoogle Scholar
  4. Anderson KM, Liao S (1968) Selective retention of dihydrotestosterone by prostatic nuclei. Nature 219:277–279PubMedCrossRefPubMedCentralGoogle Scholar
  5. Attard G, Sarker D, Reid A, Molife R, Parker C, de Bono J (2006) Improving the outcome of patients with castration-resistant prostate cancer through rational drug development. Br J Cancer 95:767–774PubMedPubMedCentralCrossRefGoogle Scholar
  6. Bemis D, Capodice J, Anastasiadis A, Katz A, Buttyan R (2005) Zyflamend, a unique herbal preparation with nonselective COX inhibitory activity, induces apoptosis of prostate cancer cells that lack COX-2 expression. Nutr Cancer 52:202–212PubMedCrossRefPubMedCentralGoogle Scholar
  7. Boileau T, Liao Z, Kim S, Lemeshow S, Erdman JW Jr, Clinton SK (2003) Prostate carcinogenesis in N-methyl-N-nitrosourea (NMU)-testosterone treated rats fed tomato powder, lycopene, or energy-restricted diets. Cancer Spectrom Knowl Environ 95:1578–1586Google Scholar
  8. Campbell DR, Kurzer MS (1993) Flavonoid inhibition of aromatase enzyme activity in human preadipocytes. J Steroid Biochem Mol Biol 46:381–388PubMedCrossRefPubMedCentralGoogle Scholar
  9. Capodice JL, Gorroochurn P, Cammack AS, Eric G, McKiernan JM, Benson MC, Stone BA, Katz AE (2009) Zyflamend in men with high-grade prostatic intraepithelial neoplasia: results of a phase I clinical trial. J Soc Integr Oncol 7:43–51PubMedPubMedCentralGoogle Scholar
  10. Caporali A, Davalli P, Astancolle S, D’Arca D, Brausi M, Bettuzzi S, Corti A (2004) The chemopreventive action of catechins in the TRAMP mouse model of prostate carcinogenesis is accompanied by clusterin over-expression. Carcinogenesis 25:2217–2224PubMedCrossRefPubMedCentralGoogle Scholar
  11. Chen L, Stacewicz-Sapuntzakis M, Duncan C, Sharifi R, Ghosh L, van Breemen R, Ashton D, Bowen PE (2001) Oxidative DNA damage in prostate cancer patients consuming tomato sauce-based entrees as a whole-food intervention. J Nat Cancer Inst 93:1872–1879PubMedCrossRefPubMedCentralGoogle Scholar
  12. Chenn S (2001) In vitro mechanism of PC spes. Urology 58:28–35PubMedCrossRefPubMedCentralGoogle Scholar
  13. Chiyomaru T, Yamamura S, Fukuhara S, Yoshino H, Kinoshita T, Majid S, Saini S, Chang I, Tanaka Y, Enokida H, Seki N, Nakagawa M, Dahiya R (2013) Genistein inhibits prostate cancer cell growth by targeting miR-34a and oncogenic HOTAIR. PLoS One 8:e70372PubMedPubMedCentralCrossRefGoogle Scholar
  14. Choi H, Cho S, Bae JH, Lee SE, Hong SK, Moon DG, Cheon J, Byun SS, Park JY (2017) Characteristics of prostate cancer by opportunistic screening in Korean men with a prostate-specific antigen level less than 4.0 ng per milliliter. Urol Int 99:143–148PubMedCrossRefPubMedCentralGoogle Scholar
  15. Dehm S, Tindall (2006) Molecular regulation of androgen action in prostate cancer. J Cell Biochem 99:333–344PubMedCrossRefPubMedCentralGoogle Scholar
  16. DeVere White R, Hackman R, Soares S, Beckett L, Li Y, Sun B (2004) Effects of a genistein rich extract on PSA levels in men with a history of prostate cancer. Urology 63:259–263PubMedCrossRefPubMedCentralGoogle Scholar
  17. Dong JT (2006) Prevalent mutations in prostate cancer. J Cell Biochem 97:433–447PubMedCrossRefPubMedCentralGoogle Scholar
  18. Donkena K, Karnes R, Young C (2010) Vitamins and prostate cancer risk. Molecules 15:1762–1783PubMedCrossRefPubMedCentralGoogle Scholar
  19. Dorai T, Diouri J, O’Shea O, Doty S (2014) Curcumin inhibits prostate cancer bone metastasis by up-regulating bone morphogenic protein-7. J Cancer Ther 5:369–386PubMedPubMedCentralCrossRefGoogle Scholar
  20. Famuyiwa T, Boe A, Diaka J, Jebelli J, Esiobu N (2016) Enhancement of genistein-induced apoptosis in LNCaP prostate cancer cells. J Cancer Prev Curr Res 4:00111Google Scholar
  21. Ferlay J, Shin H, Bray F, Forman D, Mathers C, Parkin D (2010) Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer 127:2893–2917CrossRefPubMedGoogle Scholar
  22. Guo Z, Hu X, Xing Z, Xing R, Lv R, Cheng X, Su J, Zhou Z, Xu Z, Nilsson S, Liu Z (2015) Baicalein inhibits prostate cancer cell growth and metastasis via the caveolin-1/AKT/mTOR pathway. Mol Cell Biochem 406:111–119PubMedPubMedCentralCrossRefGoogle Scholar
  23. Gupta S, Hussain T, Mukhtar H (2003) Molecular pathway for (−)-epigallocatechin-3-gallate-induced cell cycle arrest and apoptosis of human prostate carcinoma cells. Arch Biochem Biophys 410:177–185PubMedCrossRefPubMedCentralGoogle Scholar
  24. Harper C, Patel B, Wang J, Arabshahi A, Eltoum I, Lamartiniere C (2007) Resveratrol suppresses prostate cancer progression in transgenic mice. Carcinogenesis 28:1946–1953PubMedCrossRefPubMedCentralGoogle Scholar
  25. Harris W, Mostaghel E, Nelson P, Montgomery B (2009) Androgen deprivation therapy: progress in understanding mechanisms of resistance and optimizing androgen depletion. Nat Clin Pract Urol 6:76–85PubMedPubMedCentralCrossRefGoogle Scholar
  26. Hastak K, Gupta S, Ahmad N, Agarwal M, Agarwal M, Mukhtar H (2003) Role of p53 and NF-κB in epigallocatechin-3-gallate-induced apoptosis of LNCaP cells. Oncogene 22:4851–4859PubMedCrossRefPubMedCentralGoogle Scholar
  27. Hebert J, Hurley T, Olendzki B, Teas J, Ma Y, Hampl J (1998) Nutritional and socioeconomic factors in relation to prostate cancer mortality: a cross-national study. J Natl Cancer Inst 90:1637–1647PubMedCrossRefPubMedCentralGoogle Scholar
  28. Heinonen O, Koss L, Albanes D, Taylor P, Hartman A, Edwards B, Virtamo J, Huttunen J, Haapakoski J, Malila N, Rautalahti M, Ripatti S, Maenpaa H, Teerenhovi L, Virolainen M (1998) Prostate cancer and supplementation with tocopherol and carotene: incidence and mortality in a controlled trial. J Natl Cancer Inst 90:440–446PubMedCrossRefPubMedCentralGoogle Scholar
  29. Hejazi J, Rastmanesh R, Taleban F, Molana S, Ehtejab G (2013) A pilot clinical trial of radioprotective effects of curcumin supplementation in patients with prostate cancer. J Cancer Sci Ther 5:320–324Google Scholar
  30. Hsieh T, Wu J (2007) Ethanolic extracts of herbal supplement Equiguard™ suppress growth and control gene expression in CWR22Rv1 cells representing the transition of prostate cancer from androgen dependence to hormone refractory status. Int J Oncol 32:209–219Google Scholar
  31. Hsieh T, Ng C, Chang C, Chen S, Mittleman A, Wu J (1998) Induction of apoptosis and down-regulation of bcl-6 in mutu I cells treated with ethanolic extracts of the Chinese herbal supplement PC-SPES. Int J Oncol 13:1199–1202PubMedPubMedCentralGoogle Scholar
  32. Huang E, McEntee M, Whelan J (2012) Zyflamend, a combination of herbal extracts, attenuates tumor growth in murine xenograft models of prostate cancer. Nutr Cancer 64:749–760PubMedCrossRefPubMedCentralGoogle Scholar
  33. Huggins C (1946) Prostatic cancer treated by orchiectomy: the five year results. J Am Med Assoc 131:576–581PubMedCrossRefPubMedCentralGoogle Scholar
  34. Hultdin J, Van Guelpen B, Bergh A, Hallmans G, Stattin P (2004) Plasma folate, vitamin B12, and homocysteine and prostate cancer risk: a prospective study. Int J Cancer 113:819–824CrossRefGoogle Scholar
  35. Huncharek M, Haddock K, Reid R, Kupelnick B (2010) Smoking as a risk factor for prostate cancer: a meta-analysis of 24 prospective cohort studies. Am J Publ Health 100:693–701CrossRefGoogle Scholar
  36. Hwang E, Bowen P (2004) Cell cycle arrest and induction of apoptosis by lycopene in LNCaP human prostate cancer cells. J Med Food 7:284–289PubMedCrossRefPubMedCentralGoogle Scholar
  37. Hwang E, Bowen P (2005) Effects of tomato paste extracts on cell proliferation, cell-cycle arrest and apoptosis in LNCaP human prostate cancer cells. Biofactors 23:75–84PubMedCrossRefPubMedCentralGoogle Scholar
  38. Jain S, Saxena S, Kumar A (2014) Epidemiology of prostate cancer in India. Meta Gene 2:596–605PubMedPubMedCentralCrossRefGoogle Scholar
  39. Jarred RA, Keikha M, Dowling C, McPherson SJ, Clare AM, Husband AJ, Pedersen JS, Frydenberg M, Risbridger GP (2002) Induction of apoptosis in low to moderate-grade human prostate carcinoma by red clover-derived dietary isoflavones. Cancer Epidemiol Biomark Prev 11:1689–1696Google Scholar
  40. Johnson J, Bailey H, Mukhtar H (2010) Green tea polyphenols for prostate cancer chemoprevention: a translational perspective. Phytomedicine 17:3–13PubMedPubMedCentralCrossRefGoogle Scholar
  41. Karna P, Chagani S, Gundala S, Rida P, Asif G, Sharma V, Gupta M, Aneja R (2012) Benefits of whole ginger extract in prostate cancer. Brit J Nutr 107:473–484PubMedCrossRefPubMedCentralGoogle Scholar
  42. Katiyar SK, Agarwal R, Mukhtar H (1996) Inhibition of tumor promotion in SENCAR mouse skin by ethanol extract of Zingiber officinale rhizome. Cancer Res 56:1023–1030PubMedPubMedCentralGoogle Scholar
  43. Killian P, Kronski E, Astigiano S, Barbieri O, Sommerhoff C, Nerlich A, Pfeffer U, Bachmeier B (2013) Abstract 2590: curcumin inhibits prostate cancer metastasis in vivo by targeting the inflammatory cytokines CXCL1 and 2. Cancer Res 73:2590–2590CrossRefGoogle Scholar
  44. Kim S, Kundu J, Shin Y, Park J, Cho M, Kim T, Surh Y (2005a) [6]-Gingerol inhibits COX-2 expression by blocking the activation of p38 MAP kinase and NF-κB in phorbol ester-stimulated mouse skin. Oncogene 24:2558–2567PubMedCrossRefPubMedCentralGoogle Scholar
  45. Kim H, Lapointe J, Kaygusuz G, Ong D, Li C, van de Rijn M, Brooks J, Pollack J (2005b) The retinoic acid synthesis gene ALDH1a2 is a candidate tumor suppressor in prostate cancer. Cancer Res 65:8118–8124PubMedCrossRefPubMedCentralGoogle Scholar
  46. Krishnan A, Moreno J, Nonn L, Malloy P, Swami S, Peng L, Peehl D, Feldman D (2007) Novel pathways that contribute to the anti-proliferative and chemopreventive activities of calcitriol in prostate cancer. J Steril Biochem Mol Biol 103:694–702CrossRefGoogle Scholar
  47. Kumi-Diaka J, Hassanhi M, Merchant K, Horman V (2006) Influence of genistein isoflavone on matrix metalloproteinase-2 expression in prostate cancer cells. J Med Food 9:491–497PubMedCrossRefPubMedCentralGoogle Scholar
  48. Kunnumakkara A, Sung B, Ravindran J, Diagaradjane P, Deorukhkar A, Dey S, Koca C, Tong Z, Gelovani J, Guha S, Krishnan S, Aggarwal S (2011) Zyflamend suppresses growth and sensitizes human pancreatic tumors to gemcitabine in an orthotopic mouse model through modulation of multiple targets. Int J Cancer 131:E292–E303PubMedPubMedCentralCrossRefGoogle Scholar
  49. Lakshman M, Xu L, Ananthanarayanan V, Cooper J, Takimoto C, Helenowski I, Pelling J, Bergan R (2008) Dietary genistein inhibits metastasis of human prostate cancer in mice. Cancer Res 68:2024–2032PubMedCrossRefPubMedCentralGoogle Scholar
  50. Lazarevic B, Boezelijn G, Diep L, Kvernrod K, Ogren O, Ramberg H, Moen A, Wessel N, Berg R, Egge-Jacobsen W, Hammarstrom C, Svindland A, Kucuk O, Saatcioglu F, Taskèn K, Karlsen S (2011) Efficacy and safety of short-term genistein intervention in patients with localized prostate cancer prior to radical prostatectomy: a randomized, placebo-controlled, double-blind phase 2 clinical trial. Nutr Cancer 63:889–898PubMedCrossRefPubMedCentralGoogle Scholar
  51. Lippman SM, Klein EA, Goodman PJ, Lucia MS, Thompson IM, Ford LG, Parnes HL, Minasian LM, Gaziano JM, Hartline JA, Parsons JK, Bearden JD, Crawford ED, Goodman GE, Claudio J, Winquist E, Cook ED, Karp DD, Walther P, Lieber MM, Kristal AR, Darke AK, Arnold KB, Ganz PA, Santella RM, Albanes D, Taylor PR, Probstfield JL, Jagpal TJ, Crowley JJ, Meyskens FL Jr, Baker LH, Coltman CA Jr (2009) Effect of selenium and vitamin E on risk of prostate cancer and other cancers: the selenium and vitamin E cancer prevention trial (SELECT). JAMA 301:39–51PubMedCrossRefPubMedCentralGoogle Scholar
  52. Liu K, Yen C, Wu R, Yang J, Lu H, Lu K, Lo C, Chen H, Tang N, Wu C, Chung J (2012) The roles of endoplasmic reticulum stress and mitochondrial apoptotic signaling pathway in quercetin-mediated cell death of human prostate cancer PC-3 cells. Environ Toxicol 29:428–439PubMedCrossRefPubMedCentralGoogle Scholar
  53. Lu X, Hsieh T, Wu J (2004) Equiguard suppresses androgen-dependent LNCaP prostate cancer cell proliferation by targeting cell cycle control via down regulation of the retinoblastoma protein Rb and induction of apoptosis via the release of cytochrome C. Int J Oncol 25:1801–1817PubMedPubMedCentralGoogle Scholar
  54. Lu J, Chen X, Qu S, Yao B, Xu Y, Wu J, Jin Y, Ma C (2017) Oridonin induces G2/M cell cycle arrest and apoptosis via the PI3K/Akt signaling pathway in hormone-independent prostate cancer cells. Oncol Lett 13:2838–2846PubMedPubMedCentralCrossRefGoogle Scholar
  55. Malik A, Mukhtar H (2006) Prostate cancer prevention through pomegranate fruit. Cell Cycle 5:371–373PubMedCrossRefPubMedCentralGoogle Scholar
  56. Malik A, Afaq F, Safaraz S, Adhami VM, Syed DN, Mukhtar H (2005) Pomegranate fruit juice for chemoprevention and chemotherapy of prostate cancer. Proc Natl Acad Sci U S A 102:14813–14818CrossRefGoogle Scholar
  57. Marks L, DiPaola R, Nelson P, Chen S, Heber D, Belldegrun A, Lowe F, Fan J, Leaders F, Pantuck A, Tyler V (2002) PC-SPES: herbal formulation for prostate cancer. Urology 60:369–375PubMedCrossRefPubMedCentralGoogle Scholar
  58. Mukhopadhyay A, Ramos CB, Chatterjee D, Pantazis P, Aggarwal BB (2001) Curcumin downregulates cell survival mechanisms in human prostate cancer cell lines. Oncogene 20:7597–7609PubMedCrossRefPubMedCentralGoogle Scholar
  59. Mukhopadhyay A, Banerjee S, Stafford LJ, Xia C, Liu M, Aggarwal BB (2002) Curcumin-induced suppression of cell proliferation correlates with down- regulation of cyclin D1 expression and CDK4-mediated retinoblastoma protein phosphorylation. Oncogene 21:8852–8886PubMedPubMedCentralCrossRefGoogle Scholar
  60. Nakamura K, Yasunaga Y, Segawa T, Ko D, Moul J, Srivastava S, Rhim J (2002) Curcumin down-regulates AR gene expression and activation in prostate cancer cell lines. Int J Oncol 21:825–830PubMedPubMedCentralGoogle Scholar
  61. Naponelli V, Ramazzina I, Lenzi C, Bettuzzi S, Rizzi F (2017) Green tea catechins for prostate cancer prevention: present achievements and future challenges. Antioxidants 6:26PubMedCentralCrossRefGoogle Scholar
  62. Nguyen M, Ahmann F, Nagle R, Hsu C, Tangrea J, Parnes H, Sokoloff M, Gretzer M, Chow H (2012) Randomized, double-blind, placebo controlled trial of polyphenon E in prostate cancer patients before prostatectomy: evaluation of potential chemopreventive activities. Cancer Prev Res (Phila) 5:290–298PubMedCrossRefPubMedCentralGoogle Scholar
  63. Obermuller-Jevic UC, Olano-Martin E, Corbacho AM, Eiserich JP, van der Vliet A, Valacchi G, Cross CE, Packer L (2003) Lycopene inhibits the growth of normal human prostate epithelial cells in vitro. J Nutr 133:3356–3360PubMedCrossRefPubMedCentralGoogle Scholar
  64. Paganini-Hill A, Chao A, Ross RK, Henderson BE (1987) Vitamin A, beta-carotene, and the risk of cancer: a prospective study. J Natl Cancer Inst 79:443–448PubMedPubMedCentralGoogle Scholar
  65. Paller C, Ye X, Wozniak P, Gillespie B, Sieber P, Greengold R, Stockton B, Hertzman B, Efros M, Roper R, Liker H, Carducci M (2012) A randomized phase II study of pomegranate extract for men with rising PSA following initial therapy for localized prostate cancer. Prostate Cancer Prostatic Dis 16:50–55PubMedPubMedCentralCrossRefGoogle Scholar
  66. Pantuck A, Leppert J, Zomorodian N, Aronson W, Hong J, Barnard R, Seeram N, Liker H, Wang H, Elashoff R, Heber D, Aviram M, Ignarro L, Belldegrun A (2006) Phase II study of pomegranate juice for men with rising prostate-specific antigen following surgery or radiation for prostate cancer. Clin Cancer Res 12:4018–4026PubMedCrossRefPubMedCentralGoogle Scholar
  67. Peterson G, Barnes S (1993) Genistein and biochanin A inhibit the growth of human prostate cancer cells but not epidermal growth factor receptor tyrosine autophosphorylation. Prostate 22:335–345PubMedCrossRefPubMedCentralGoogle Scholar
  68. Pezzato E, Sartor L, Dell’Aica I, Dittadi R, Gion M, Belluco C, Lise M, Garbisa S (2004) Prostate carcinoma and green tea: PSA-triggered basement membrane degradation and MMP-2 activation are inhibited by (-) epigallocatechin-3-gallate. Int J Cancer 112:787–792PubMedCrossRefPubMedCentralGoogle Scholar
  69. Rackley J, Clark P, Hall M (2006) Complementary and alternative medicine for advanced prostate cancer. Urol Clin N Am 33:237–246CrossRefGoogle Scholar
  70. Raja Singh P, Arunkumar R, Sivakamasundari V, Sharmila G, Elumalai P, Suganthapriya E, Brindha Mercy A, Senthilkumar K, Arunakaran J (2013) Anti-proliferative and apoptosis inducing effect of nimbolide by altering molecules involved in apoptosis and IGF signalling via PI3K/Akt in prostate cancer (PC-3) cell line. Cell Biochem Funct 32:217–228PubMedCrossRefPubMedCentralGoogle Scholar
  71. Rizzi F, Naponelli V, Silva A, Modernelli A, Ramazzina I, Bonacini M, Tardito S, Gatti R, Uggeri J, Bettuzzi S (2013) Polyphenon E, a standardized green tea extract, induces endoplasmic reticulum stress, leading to death of immortalized PNT1a cells by anoikis and tumorigenic PC3 by necroptosis. Carcinogenesis 35:828–839PubMedCrossRefPubMedCentralGoogle Scholar
  72. Saha A, Blando J, Silver E, Beltran L, Sessler J, DiGiovanni J (2014) 6-Shogaol from dried ginger inhibits growth of prostate Cancer cells both in vitro and in vivo through inhibition of STAT3 and NF- B signaling. Cancer Prev Res 7:627–638CrossRefGoogle Scholar
  73. Sandur S, Ahn K, Ichikawa H, Sethi G, Shishodia S, Newman R, Aggarwal B (2007) Zyflamend, a polyherbal preparation, inhibits invasion, suppresses osteoclastogenesis, and potentiates apoptosis through down-regulation of NF-κ B activation and NF-κ B–regulated gene products. Nutr Cancer 57:78–87PubMedCrossRefPubMedCentralGoogle Scholar
  74. Schuurman AG, Goldbohm AR, Brants H, Brandt P (2002) A prospective cohort study on intake of retinol, vitamins C and E, and carotenoids and prostate cancer risk (Netherlands). Cancer Causes Control 13:573–582PubMedCrossRefPubMedCentralGoogle Scholar
  75. Seeni A, Takahashi S, Takeshita K, Tang M, Sugiura S, Sato SY, Shirai T (2008) Suppression of prostate cancer growth by resveratrol in the transgenic rat for adenocarcinoma of prostate (TRAP) model. Asian Pac J Cancer Prev 9:7–14PubMedPubMedCentralGoogle Scholar
  76. Seo Y, Kim B, Chun S, Park Y, Kang K, Kwon T (2011) Apoptotic effects of genistein, biochanin-A and apigenin on LNCaP and PC-3 cells by p21 through transcriptional inhibition of polo-like kinase-1. J Korean Med Sci 26:1489–1494PubMedPubMedCentralCrossRefGoogle Scholar
  77. Sha J, Li J, Wang W, Pan L, Cheng J, Li L, Zhao H, Lin W (2016) Curcumin induces G0/G1 arrest and apoptosis in hormone independent prostate cancer DU-145 cells by down regulating notch signaling. Biomed Pharmacother 84:177–184PubMedCrossRefPubMedCentralGoogle Scholar
  78. Sharmila G, Athirai T, Kiruthiga B, Senthilkumar K, Elumalai P, Arunkumar R, Arunakaran J (2013) Chemopreventive effect of quercetin in MNU and testosterone induced prostate cancer of sprague-Dawley rats. Nutr Cancer 66:38–46PubMedCrossRefPubMedCentralGoogle Scholar
  79. Siddiqui I, Asim M, Hafeez B, Adhami V, Tarapore R, Mukhtar H (2010) Green tea polyphenol EGCG blunts androgen receptor function in prostate cancer. FASEB J 25:1198–1207PubMedCrossRefPubMedCentralGoogle Scholar
  80. Singh S, Aggarwal B (1995) Activation of transcription factor NF- B is suppressed by curcumin (Diferuloylmethane). J Biol Chem 270:24995–25000PubMedPubMedCentralCrossRefGoogle Scholar
  81. Singh P, Priya E, Balakrishnan S, Arunkumar R, Sharmila G, Rajalakshmi M, Arunakaran J (2016) Nimbolide inhibits androgen independent prostate cancer cells survival and proliferation by modulating multiple pro-survival signaling pathways. Biomed Pharmacother 84:1623–1634PubMedCrossRefPubMedCentralGoogle Scholar
  82. Skinner H, Schwartz G (2008) Serum calcium and incident and fatal prostate cancer in the National Health and nutrition examination survey. Cancer Epidemiol Biomark Prev 17:2302–2305CrossRefGoogle Scholar
  83. Small E, Frohlich M, Bok R, Shinohara K, Grossfeld G, Rozenblat Z, Kelly W, Corry M, Reese D (2000) Prospective trial of the herbal supplement PC-SPES in patients with progressive prostate Cancer. J Clin Oncol 18:3595–3603PubMedCrossRefPubMedCentralGoogle Scholar
  84. Srinivas-Shankar U, Wu F (2006) Drug insight: testosterone preparations. Nat Clin Pract Urol 3:653–665PubMedCrossRefPubMedCentralGoogle Scholar
  85. Sun XY, Plouzek CA, Henry JP, Wang TT, Phang JM (1998) Increased UDP-glucuronosyltransferase activity and decreased prostate specific antigen production by biochanin A in prostate cancer cells. Cancer Res 58:2379–2384PubMedPubMedCentralGoogle Scholar
  86. Surh YJ (2002) Anti-tumor promoting potential of selected spice ingredients with antioxidative and anti-inflammatory activities: a short review. Food Chem Toxicol 40:1091–1097PubMedCrossRefPubMedCentralGoogle Scholar
  87. Szliszka E, Sokół-Łętowska A, Kucharska A, Jaworska D, Czuba Z, Król W (2013) Ethanolic extract of polish propolis: chemical composition and TRAIL-R2 death receptor targeting apoptotic activity against prostate cancer cells. Evidence-Based Compl Altern Med 2013:757628. Google Scholar
  88. Tang L, Jin T, Zeng X, Wang JS (2005) Lycopene inhibits the growth of human androgen-independent prostate cancer cells in vitro and in BALB/c nude mice. J Nutr 135:287–290PubMedCrossRefPubMedCentralGoogle Scholar
  89. Taniguchi T, Iizumi Y, Watanabe M, Masuda M, Morita M, Aono Y, Toriyama S, Oishi M, Goi W, Sakai T (2016) Resveratrol directly targets DDX5 resulting in suppression of the mTORC1 pathway in prostate cancer. Cell Death Dis 7:e2211. CrossRefGoogle Scholar
  90. Thomas R, Williams M, Sharma H, Chaudry A, Bellamy P (2014) A double-blind, placebo-controlled randomised trial evaluating the effect of a polyphenol rich whole food supplement on PSA progression in men with prostate cancer-the UK NCRN Pomi-T study. Prostate Cancer Prostatic Dis 17:180–186PubMedPubMedCentralCrossRefGoogle Scholar
  91. Tiwari R, Geliebter J, Garikapaty V, Yedavelli S, Chen S, Mittelman A (1999) Anti-tumor effects of PC-SPES, an herbal formulation in prostate cancer. Int J Oncol 14:713–719PubMedPubMedCentralGoogle Scholar
  92. Von Löw EC, Perabo FG, Siener R, Müller SC (2007) Facts and fiction of phytotherapy for prostate cancer: a critical assessment of preclinical and clinical data. In Vivo 21:189–204Google Scholar
  93. Wang Q, Carroll J, Brown M (2005) Spatial and temporal recruitment of androgen receptor and its co-activators involves chromosomal looping and polymerase tracking. Mol Cell 19:631–642PubMedCrossRefPubMedCentralGoogle Scholar
  94. Wu Q, Kohli M, Bergen H, Cheville J, Karnes R, Cao H, Young C, Tindall D, McNiven M, Donkena K (2014) Preclinical evaluation of the supercritical extract of Azadirachta indica (Neem) leaves in vitro and in vivo on inhibition of prostate cancer tumor growth. Mol Cancer Ther 13:1067–1077PubMedPubMedCentralCrossRefGoogle Scholar
  95. Xing N, Chen Y, Mitchell S, Young C (2001) Quercetin inhibits the expression and function of the androgen receptor in LNCaP prostate cancer cells. Carcinogenesis 22:409–414PubMedCrossRefPubMedCentralGoogle Scholar
  96. Yan J, Xie B, Capodice J, Katz A (2011) Zyflamend inhibits the expression and function of androgen receptor and acts synergistically with bicalutamide to inhibit prostate cancer cell growth. Prostate 72:244–252PubMedCrossRefPubMedCentralGoogle Scholar
  97. Yang P, Cartwright C, Chan D, Vijjeswarapu M, Ding J, Newman R (2007) Zyflamend®-mediated inhibition of human prostate cancer PC3 cell proliferation: effects on 12-LOX and Rb protein phosphorylation. Cancer Biol Ther 6:228–236PubMedCrossRefPubMedCentralGoogle Scholar
  98. Yang F, Song L, Wang H, Wang J, Xu Z, Xing N (2015) Combination of Quercetin and 2-methoxyestradiol enhances inhibition of human prostate cancer LNCaP and PC-3 cells xenograft tumor growth. PLoS One 10:e0128277. PubMedPubMedCentralCrossRefGoogle Scholar
  99. Yang J, Wang C, Zhang Z, Chen X, Jia Y, Wang B, Kong T (2017) Curcumin inhibits the survival and metastasis of prostate cancer cells via the Notch-1 signaling pathway. APMIS 125:134–140PubMedCrossRefPubMedCentralGoogle Scholar
  100. Yılmaz B (2010) Therapeutic use of pomegranate (Punica granatum). Turk Aile Hekim Derg 14:146–153CrossRefGoogle Scholar
  101. Zhang J, Wu M, Schoene N, Cheng W, Wang T, Alshatwi A, Alsaif M, Lei K (2009) Effect of resveratrol and zinc on intracellular zinc status in normal human prostate epithelial cells. AJP: Cell Physiol 297:C632–C644Google Scholar
  102. Zhang J, Ahn K, Kim C, Shanmugam M, Siveen K, Arfuso F, Samym R, Deivasigamanim A, Lim L, Wang L, Goh B, Kumar A, Hui K, Sethi G (2016) Nimbolide induced oxidative stress abrogates STAT3 signaling cascade and inhibits tumor growth in transgenic adenocarcinoma of mouse prostate model. Antioxid Redox Signal 24:575–589PubMedCrossRefPubMedCentralGoogle Scholar
  103. Zhao Y, Donohoe D, Huang E, Whelan J (2015) Zyflamend, a polyherbal mixture, inhibits lipogenesis and mTORC1 signalling via activation of AMPK. J Funct Foods 18:147–158CrossRefGoogle Scholar

Copyright information

© Springer Nature Singapore Pte Ltd. 2018

Authors and Affiliations

  • Priyadarshini
    • 1
  • Abhishek Negi
    • 1
  1. 1.Department of BiotechnologyJaypee Institute of Information TechnologyNoidaIndia

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