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Ocular Imaging

  • Alexander Barash
  • Richard I. Kaplan
  • Meenakashi Gupta
Chapter
Part of the Current Practices in Ophthalmology book series (CUPROP)

Abstract

Advances in retinal imaging are allowing unprecedented in vivo views of posterior segment structures. Recent expansion of optical coherence tomography (OCT) techniques, such as enhanced depth imaging, swept source, en-face, and widefield, is deepening our understanding of the retina, as well as the choroidal and vitreous structures. OCT angiography is allowing detailed views of retinal and choroidal vasculature. The introduction of OCT into the operating room is beginning to alter surgical decision-making. Widefield imaging techniques are redefining our characterization and treatment of diseases of the retinal periphery. Autofluorescence provides additional insight into the health of the retina. Individual cells are now being visualized using adaptive optics.

Keywords

Retinal imaging Optical coherence tomography OCT Enhanced depth imaging OCT Swept-source OCT Widefield OCT En-face OCT OCT angiography Intraoperative OCT Ultrawidefield imaging Fundus autofluorescence Adaptive optics 

References

  1. 1.
    Kaluzny JJ, Wojtkowski M, Sikorski BL, Szkulmowski M, Szkulmowska A, Bajraszewski T, et al. Analysis of the outer retina reconstructed by high-resolution, three-dimensional spectral domain optical coherence tomography. Ophthalmic Surg Lasers Imaging. 2009;40(2):102–8.PubMedPubMedCentralCrossRefGoogle Scholar
  2. 2.
    Wong IY, Koizumi H, Lai WW. Enhanced depth imaging optical coherence tomography. Ophthalmic Surg Lasers Imaging. 2011;42 Suppl:S75–84.PubMedCrossRefGoogle Scholar
  3. 3.
    Spaide RF, Koizumi H, Pozzoni MC. Enhanced depth imaging spectral-domain optical coherence tomography. Am J Ophthalmol. 2008;146(4):496–500.PubMedCrossRefGoogle Scholar
  4. 4.
    Margolis R, Spaide RF. A pilot study of enhanced depth imaging optical coherence tomography of the choroid in normal eyes. Am J Ophthalmol. 2009;147(5):811–5.PubMedCrossRefGoogle Scholar
  5. 5.
    Wei WB, Xu L, Jonas JB, Shao L, Du KF, Wang S, et al. Subfoveal choroidal thickness: the Beijing eye study. Ophthalmology. 2013;120(1):175–80.PubMedCrossRefGoogle Scholar
  6. 6.
    Fujiwara T, Imamura Y, Margolis R, Slakter JS, Spaide RF. Enhanced depth imaging optical coherence tomography of the choroid in highly myopic eyes. Am J Ophthalmol. 2009;148(3):445–50.PubMedCrossRefGoogle Scholar
  7. 7.
    Tan CS, Ouyang Y, Ruiz H, Sadda SR. Diurnal variation of choroidal thickness in normal, healthy subjects measured by spectral domain optical coherence tomography. Invest Ophthalmol Vis Sci. 2012;53(1):261–6.PubMedCrossRefGoogle Scholar
  8. 8.
    Jirarattanasopa P, Ooto S, Tsujikawa A, Yamashiro K, Hangai M, Hirata M, et al. Assessment of macular choroidal thickness by optical coherence tomography and angiographic changes in central serous chorioretinopathy. Ophthalmology. 2012;119(8):1666–78.PubMedCrossRefGoogle Scholar
  9. 9.
    Yang L, Jonas JB, Wei W. Choroidal vessel diameter in central serous chorioretinopathy. Acta Ophthalmol. 2013;91(5):e358–62.PubMedCrossRefGoogle Scholar
  10. 10.
    Kang NH, Kim YT. Change in subfoveal choroidal thickness in central serous chorioretinopathy following spontaneous resolution and low-fluence photodynamic therapy. Eye (Lond). 2013;27(3):387–91.CrossRefGoogle Scholar
  11. 11.
    Yang LH, Jonas JB, Wei WB. Optical coherence tomographic enhanced depth imaging of polypoidal choroidal vasculopathy. Retina. 2013;33(8):1584–9.PubMedCrossRefPubMedCentralGoogle Scholar
  12. 12.
    Fong AH, Li KK, Wong D. Choroidal evaluation using enhanced depth imaging spectral-domain optical coherence tomography in Vogt-Koyanagi-Harada disease. Retina. 2011;31(3):502–9.PubMedCrossRefGoogle Scholar
  13. 13.
    Maruko I, Iida T, Sugano Y, Oyamada H, Sekiryu T, Fujiwara T, et al. Subfoveal choroidal thickness after treatment of Vogt-Koyanagi-Harada disease. Retina. 2011;31(3):510–7.PubMedCrossRefGoogle Scholar
  14. 14.
    Kim M, Kim H, Kwon HJ, Kim SS, Koh HJ, Lee SC. Choroidal thickness in Behcet’s uveitis: an enhanced depth imaging-optical coherence tomography and its association with angiographic changes. Invest Ophthalmol Vis Sci. 2013;54(9):6033–9.PubMedCrossRefGoogle Scholar
  15. 15.
    Hua R, Chen K, Liu LM, Liu NN, Chen L, Teng WP. Multi-modality imaging on multiple evanescent white dot syndrome-a spectralis study. Int J Ophthalmol. 2012;5(5):644–7.PubMedPubMedCentralGoogle Scholar
  16. 16.
    Hirukawa K, Keino H, Watanabe T, Okada AA. Enhanced depth imaging optical coherence tomography of the choroid in new-onset acute posterior scleritis. Graefes Arch Clin Exp Ophthalmol. 2013;251(9):2273–5.PubMedCrossRefGoogle Scholar
  17. 17.
    Spaide RF. Age-related choroidal atrophy. Am J Ophthalmol. 2009;147(5):801–10.PubMedCrossRefGoogle Scholar
  18. 18.
    Yeoh J, Rahman W, Chen F, Hooper C, Patel P, Tufail A, et al. Choroidal imaging in inherited retinal disease using the technique of enhanced depth imaging optical coherence tomography. Graefes Arch Clin Exp Ophthalmol. 2010;248(12):1719–28.PubMedCrossRefGoogle Scholar
  19. 19.
    Dhoot DS, Huo S, Yuan A, Xu D, Srivistava S, Ehlers JP, et al. Evaluation of choroidal thickness in retinitis pigmentosa using enhanced depth imaging optical coherence tomography. Br J Ophthalmol. 2013;97(1):66–9.PubMedCrossRefGoogle Scholar
  20. 20.
    Ayton LN, Guymer RH, Luu CD. Choroidal thickness profiles in retinitis pigmentosa. Clin Exp Ophthalmol. 2013;41(4):396–403.PubMedCrossRefGoogle Scholar
  21. 21.
    Nishida Y, Fujiwara T, Imamura Y, Lima LH, Kurosaka D, Spaide RF. Choroidal thickness and visual acuity in highly myopic eyes. Retina. 2012;32(7):1229–36.PubMedCrossRefGoogle Scholar
  22. 22.
    Yamazaki T, Koizumi H, Yamagishi T, Kinoshita S. Subfoveal choroidal thickness after ranibizumab therapy for neovascular age-related macular degeneration: 12-month results. Ophthalmology. 2012;119(8):1621–7.PubMedCrossRefGoogle Scholar
  23. 23.
    Branchini L, Regatieri C, Adhi M, Flores-Moreno I, Manjunath V, Fujimoto JG, et al. Effect of intravitreous anti-vascular endothelial growth factor therapy on choroidal thickness in neovascular age-related macular degeneration using spectral-domain optical coherence tomography. JAMA Ophthalmol. 2013;131(5):693–4.PubMedPubMedCentralCrossRefGoogle Scholar
  24. 24.
    Torres VL, Brugnoni N, Kaiser PK, Singh AD. Optical coherence tomography enhanced depth imaging of choroidal tumors. Am J Ophthalmol. 2011;151(4):586–93. e2.PubMedCrossRefGoogle Scholar
  25. 25.
    Shields CL, Kaliki S, Rojanaporn D, Ferenczy SR, Shields JA. Enhanced depth imaging optical coherence tomography of small choroidal melanoma: comparison with choroidal nevus. Arch Ophthalmol. 2012;130(7):850–6.PubMedCrossRefGoogle Scholar
  26. 26.
    Cennamo G, Romano MR, Breve MA, Velotti N, Reibaldi M, de Crecchio G, et al. Evaluation of choroidal tumors with optical coherence tomography: enhanced depth imaging and OCT-angiography features. Eye (Lond). 2017;31(6):906–15.CrossRefGoogle Scholar
  27. 27.
    Adhi M, Liu JJ, Qavi AH, Grulkowski I, Lu CD, Mohler KJ, et al. Choroidal analysis in healthy eyes using swept-source optical coherence tomography compared to spectral domain optical coherence tomography. Am J Ophthalmol. 2014;157(6):1272–81. e1.PubMedCrossRefGoogle Scholar
  28. 28.
    Muqit MM, Stanga PE. Swept-source optical coherence tomography imaging of the cortical vitreous and the vitreoretinal interface in proliferative diabetic retinopathy: assessment of vitreoschisis, neovascularisation and the internal limiting membrane. Br J Ophthalmol. 2014;98(7):994–7.PubMedCrossRefGoogle Scholar
  29. 29.
    Adhi M, Badaro E, Liu JJ, Kraus MF, Baumal CR, Witkin AJ, et al. Three-dimensional enhanced imaging of vitreoretinal interface in diabetic retinopathy using swept-source optical coherence tomography. Am J Ophthalmol. 2016;162:140–9. e1.PubMedCrossRefGoogle Scholar
  30. 30.
    Copete S, Flores-Moreno I, Montero JA, Duker JS, Ruiz-Moreno JM. Direct comparison of spectral-domain and swept-source OCT in the measurement of choroidal thickness in normal eyes. Br J Ophthalmol. 2014;98(3):334–8.PubMedCrossRefGoogle Scholar
  31. 31.
    Adhi M, Liu JJ, Qavi AH, Grulkowski I, Fujimoto JG, Duker JS. Enhanced visualization of the choroido-scleral interface using swept-source OCT. Ophthalmic Surg Lasers Imaging Retina. 2013;44(6 Suppl):S40–2.PubMedCrossRefGoogle Scholar
  32. 32.
    Dansingani KK, Balaratnasingam C, Naysan J, Freund KB. En face imaging of pachychoroid spectrum disorders with swept-source optical coherence tomography. Retina. 2016;36(3):499–516.PubMedCrossRefGoogle Scholar
  33. 33.
    Francis JH, Pang CE, Abramson DH, Milman T, Folberg R, Mrejen S, et al. Swept-source optical coherence tomography features of choroidal nevi. Am J Ophthalmol. 2015;159(1):169–76. e1.PubMedCrossRefGoogle Scholar
  34. 34.
    Choudhry N, Golding J, Manry MW, Rao RC. Ultra-widefield steering-based spectral-domain optical coherence tomography imaging of the retinal periphery. Ophthalmology. 2016;123(6):1368–74.PubMedPubMedCentralCrossRefGoogle Scholar
  35. 35.
    McNabb RP, Grewal DS, Mehta R, Schuman SG, Izatt JA, Mahmoud TH, et al. Wide field of view swept-source optical coherence tomography for peripheral retinal disease. Br J Ophthalmol. 2016;100(10):1377–82.PubMedPubMedCentralCrossRefGoogle Scholar
  36. 36.
    Savastano MC, Rispoli M, Savastano A, Lumbroso B. En face optical coherence tomography for visualization of the choroid. Ophthalmic Surg Lasers Imaging Retina. 2015;46(5):561–5.PubMedCrossRefGoogle Scholar
  37. 37.
    Yannuzzi LA, Sorenson J, Spaide RF, Lipson B. Idiopathic polypoidal choroidal vasculopathy (IPCV). Retina. 1990;10(1):1–8.PubMedCrossRefGoogle Scholar
  38. 38.
    Coscas G, Lupidi M, Coscas F, Benjelloun F, Zerbib J, Dirani A, et al. Toward a specific classification of polypoidal choroidal vasculopathy: idiopathic disease or subtype of age-related macular degeneration. Invest Ophthalmol Vis Sci. 2015;56(5):3187–95.PubMedCrossRefGoogle Scholar
  39. 39.
    Spaide RF, Yannuzzi LA, Slakter JS, Sorenson J, Orlach DA. Indocyanine green videoangiography of idiopathic polypoidal choroidal vasculopathy. Retina. 1995;15(2):100–10.PubMedCrossRefGoogle Scholar
  40. 40.
    Ojima Y, Hangai M, Sakamoto A, Tsujikawa A, Otani A, Tamura H, et al. Improved visualization of polypoidal choroidal vasculopathy lesions using spectral-domain optical coherence tomography. Retina. 2009;29(1):52–9.PubMedCrossRefGoogle Scholar
  41. 41.
    Semoun O, Coscas F, Coscas G, Lalloum F, Srour M, Souied EH. En face enhanced depth imaging optical coherence tomography of polypoidal choroidal vasculopathy. Br J Ophthalmol. 2016;100(8):1028–34.PubMedCrossRefGoogle Scholar
  42. 42.
    Sayanagi K, Gomi F, Akiba M, Sawa M, Hara C, Nishida K. En-face high-penetration optical coherence tomography imaging in polypoidal choroidal vasculopathy. Br J Ophthalmol. 2015;99(1):29–35.PubMedCrossRefGoogle Scholar
  43. 43.
    Flores-Moreno I, Arias-Barquet L, Rubio-Caso MJ, Ruiz-Moreno JM, Duker JS, Caminal JM. En face swept-source optical coherence tomography in neovascular age-related macular degeneration. Br J Ophthalmol. 2015;99(9):1260–7.PubMedCrossRefGoogle Scholar
  44. 44.
    Nunes RP, Gregori G, Yehoshua Z, Stetson PF, Feuer W, Moshfeghi AA, et al. Predicting the progression of geographic atrophy in age-related macular degeneration with SD-OCT en face imaging of the outer retina. Ophthalmic Surg Lasers Imaging Retina. 2013;44(4):344–59.PubMedCrossRefGoogle Scholar
  45. 45.
    Pilotto E, Convento E, Guidolin F, Abalsamo CK, Longhin E, Parrozzani R, et al. Microperimetry features of geographic atrophy identified with en face optical coherence tomography. JAMA Ophthalmol. 2016;134(8):873–9.PubMedCrossRefGoogle Scholar
  46. 46.
    Pilotto E, Guidolin F, Convento E, Antonini R, Stefanon FG, Parrozzani R, et al. En face optical coherence tomography to detect and measure geographic atrophy. Invest Ophthalmol Vis Sci. 2015;56(13):8120–4.PubMedCrossRefGoogle Scholar
  47. 47.
    Schaal KB, Gregori G, Rosenfeld PJ. En face optical coherence tomography imaging for the detection of nascent geographic atrophy. Am J Ophthalmol. 2017;174:145–54.PubMedCrossRefGoogle Scholar
  48. 48.
    Yehoshua Z, de Amorim Garcia Filho CA, Nunes RP, Gregori G, Penha FM, Moshfeghi AA, et al. Comparison of geographic atrophy growth rates using different imaging modalities in the COMPLETE study. Ophthalmic Surg Lasers Imaging Retina. 2015;46(4):413–22.PubMedCrossRefGoogle Scholar
  49. 49.
    Yehoshua Z, Garcia Filho CAA, Penha FM, Gregori G, Stetson PF, Feuer WJ, et al. Comparison of geographic atrophy measurements from the OCT fundus image and the sub-RPE slab image. Ophthalmic Surg Lasers Imaging Retina. 2013;44(2):127–32.PubMedCrossRefGoogle Scholar
  50. 50.
    Rispoli M, Le Rouic J-F, Lesnoni G, Colecchio L, Catalano S, Lumbroso B. Retinal surface en face optical coherence tomography: a new imaging approach in epiretinal membrane surgery. Retina. 2012;32(10):2070–6.PubMedCrossRefGoogle Scholar
  51. 51.
    Greven MA, Elkin Z, Nelson RW, Leng T. En face imaging of epiretinal membranes and the retinal nerve fiber layer using swept-source optical coherence tomography. Ophthalmic Surg Lasers Imaging Retina. 2016;47(8):730–4.PubMedCrossRefGoogle Scholar
  52. 52.
    Clamp MF, Jumper JM, McDonald HR, Fu AD, Lujan BJ. Sequential en face spectral-domain optical coherence tomographic analysis of macular hole formation. JAMA Ophthalmol. 2015;133(4):486–8.PubMedCrossRefGoogle Scholar
  53. 53.
    Clamp MF, Wilkes G, Leis LS, McDonald HR, Johnson RN, Jumper JM, et al. En face spectral domain optical coherence tomography analysis of lamellar macular holes. Retina. 2014;34(7):1360–6.PubMedCrossRefGoogle Scholar
  54. 54.
    Prünte C, Flammer J. Choroidal capillary and venous congestion in central serous chorioretinopathy. Am J Ophthalmol. 1996;121(1):26–34.PubMedCrossRefGoogle Scholar
  55. 55.
    Imamura Y, Fujiwara T, Margolis R, Spaide RF. Enhanced depth imaging optical coherence tomography of the choroid in central serous chorioretinopathy. Retina. 2009;29(10):1469–73.PubMedCrossRefGoogle Scholar
  56. 56.
    van Velthoven MEJ, Verbraak FD, Garcia PM, Schlingemann RO, Rosen RB, de Smet MD. Evaluation of central serous retinopathy with en face optical coherence tomography. Br J Ophthalmol. 2005;89(11):1483–8.PubMedPubMedCentralCrossRefGoogle Scholar
  57. 57.
    Lehmann M, Wolff B, Vasseur V, Martinet V, Manasseh N, Sahel J-A, et al. Retinal and choroidal changes observed with ‘En face’ enhanced-depth imaging OCT in central serous chorioretinopathy. Br J Ophthalmol. 2013;97(9):1181–6.PubMedCrossRefGoogle Scholar
  58. 58.
    Thomas BJ, Albini TA, Flynn HW. Multiple evanescent white dot syndrome: multimodal imaging and correlation with proposed pathophysiology. Ophthalmic Surg Lasers Imaging Retina. 2013;44(6):584–7.PubMedCrossRefGoogle Scholar
  59. 59.
    De Bats F, Wolff B, Vasseur V, Affortit A, Kodjikian L, Sahel J-A, et al. “En-face” spectral-domain optical coherence tomography findings in multiple evanescent white dot syndrome. J Ophthalmol. 2014;2014:928028–6.PubMedGoogle Scholar
  60. 60.
    van Velthoven MEJ, Verbraak FD, Yannuzzi LA, Rosen RB, Podoleanu AGH, de Smet MD. Imaging the retina by en face optical coherence tomography. Retina. 2006;26(2):129–36.PubMedCrossRefGoogle Scholar
  61. 61.
    Chen CL, Wang RK. Optical coherence tomography based angiography [invited]. Biomed Opt Express. 2017;8(2):1056–82.PubMedPubMedCentralCrossRefGoogle Scholar
  62. 62.
    Sambhav K, Grover S, Chalam KV. The application of optical coherence tomography angiography in retinal diseases. Surv Ophthalmol. 2017;62(6):838–66.PubMedCrossRefGoogle Scholar
  63. 63.
    Minvielle W, Caillaux V, Cohen SY, Chasset F, Zambrowski O, Miere A, et al. Macular Microangiopathy in sickle cell disease using optical coherence tomography angiography. Am J Ophthalmol. 2016;164:137–44. e1.PubMedCrossRefGoogle Scholar
  64. 64.
    Zeimer M, Gutfleisch M, Heimes B, Spital G, Lommatzsch A, Pauleikhoff D. Association between changes in macular vasculature in optical coherence tomography- and fluorescein- angiography and distribution of macular pigment in type 2 idiopathic macular telangiectasia. Retina. 2015;35(11):2307–16.PubMedCrossRefGoogle Scholar
  65. 65.
    Costanzo E, Cohen SY, Miere A, Querques G, Capuano V, Semoun O, et al. Optical coherence tomography angiography in central serous Chorioretinopathy. J Ophthalmol. 2015;2015:134783.PubMedPubMedCentralCrossRefGoogle Scholar
  66. 66.
    Miyata M, Ooto S, Hata M, Yamashiro K, Tamura H, Akagi-Kurashige Y, et al. Detection of myopic Choroidal neovascularization using optical coherence tomography angiography. Am J Ophthalmol. 2016;165:108–14.PubMedCrossRefPubMedCentralGoogle Scholar
  67. 67.
    Veverka KK, AbouChehade JE, Iezzi R Jr, Pulido JS. Noninvasive grading of radiation retinopathy: the use of optical coherence tomography angiography. Retina. 2015;35(11):2400–10.PubMedCrossRefGoogle Scholar
  68. 68.
    Coscas F, Sellam A, Glacet-Bernard A, Jung C, Goudot M, Miere A, et al. Normative data for vascular density in superficial and deep capillary plexuses of healthy adults assessed by optical coherence tomography angiography. Invest Ophthalmol Vis Sci. 2016;57(9):OCT211–23.PubMedCrossRefGoogle Scholar
  69. 69.
    Samara WA, Say EA, Khoo CT, Higgins TP, Magrath G, Ferenczy S, et al. Correlation of foveal avascular zone size with foveal morphology in normal eyes using optical coherence tomography angiography. Retina. 2015;35(11):2188–95.PubMedCrossRefGoogle Scholar
  70. 70.
    Tan CS, Lim LW, Chow VS, Chay IW, Tan S, Cheong KX, et al. Optical coherence tomography angiography evaluation of the parafoveal vasculature and its relationship with ocular factors. Invest Ophthalmol Vis Sci. 2016;57(9):OCT224–34.PubMedCrossRefGoogle Scholar
  71. 71.
    Shahlaee A, Samara WA, Hsu J, Say EA, Khan MA, Sridhar J, et al. In vivo assessment of macular vascular density in healthy human eyes using optical coherence tomography angiography. Am J Ophthalmol. 2016;165:39–46.PubMedCrossRefGoogle Scholar
  72. 72.
    Ishibazawa A, Nagaoka T, Takahashi A, Omae T, Tani T, Sogawa K, et al. Optical coherence tomography angiography in diabetic retinopathy: a prospective pilot study. Am J Ophthalmol. 2015;160(1):35–44. e1PubMedCrossRefGoogle Scholar
  73. 73.
    Matsunaga DR, Yi JJ, De Koo LO, Ameri H, Puliafito CA, Kashani AH. Optical coherence tomography angiography of diabetic retinopathy in human subjects. Ophthalmic Surg Lasers Imaging Retina. 2015;46(8):796–805.PubMedCrossRefGoogle Scholar
  74. 74.
    Lee J, Rosen R. Optical coherence tomography angiography in diabetes. Curr Diab Rep. 2016;16(12):123.PubMedCrossRefGoogle Scholar
  75. 75.
    Hwang TS, Jia Y, Gao SS, Bailey ST, Lauer AK, Flaxel CJ, et al. Optical coherence tomography angiography features of diabetic retinopathy. Retina. 2015;35(11):2371–6.PubMedPubMedCentralCrossRefGoogle Scholar
  76. 76.
    Takase N, Nozaki M, Kato A, Ozeki H, Yoshida M, Ogura Y. Enlargement of Foveal avascular zone in diabetic eyes evaluated by en face optical coherence tomography angiography. Retina. 2015;35(11):2377–83.PubMedCrossRefGoogle Scholar
  77. 77.
    Agemy SA, Scripsema NK, Shah CM, Chui T, Garcia PM, Lee JG, et al. Retinal vascular perfusion density mapping using optical coherence tomography angiography in Normals and diabetic retinopathy patients. Retina. 2015;35(11):2353–63.PubMedCrossRefGoogle Scholar
  78. 78.
    Schmidt-Erfurth U, Klimscha S, Waldstein SM, Bogunovic H. A view of the current and future role of optical coherence tomography in the management of age-related macular degeneration. Eye (Lond). 2017;31(1):26–44.CrossRefGoogle Scholar
  79. 79.
    Kuehlewein L, Bansal M, Lenis TL, Iafe NA, Sadda SR, Bonini Filho MA, et al. Optical coherence tomography angiography of type 1 neovascularization in age-related macular degeneration. Am J Ophthalmol. 2015;160(4):739–48. e2.PubMedCrossRefGoogle Scholar
  80. 80.
    Kim JY, Kwon OW, Oh HS, Kim SH, You YS. Optical coherence tomography angiography in patients with polypoidal choroidal vasculopathy. Graefes Arch Clin Exp Ophthalmol. 2016;254(8):1505–10.PubMedCrossRefGoogle Scholar
  81. 81.
    Coscas F, Glacet-Bernard A, Miere A, Caillaux V, Uzzan J, Lupidi M, et al. Optical coherence tomography angiography in retinal vein occlusion: evaluation of superficial and deep capillary plexa. Am J Ophthalmol. 2016;161:160–71. e1–2.PubMedCrossRefGoogle Scholar
  82. 82.
    Nobre Cardoso J, Keane PA, Sim DA, Bradley P, Agrawal R, Addison PK, et al. Systematic evaluation of optical coherence tomography angiography in retinal vein occlusion. Am J Ophthalmol. 2016;163:93–107. e6.PubMedCrossRefGoogle Scholar
  83. 83.
    Kashani AH, Lee SY, Moshfeghi A, Durbin MK, Puliafito CA. Optical coherence tomography angiography of retinal venous occlusion. Retina. 2015;35(11):2323–31.PubMedCrossRefGoogle Scholar
  84. 84.
    de Carlo TE, Romano A, Waheed NK, Duker JS. A review of optical coherence tomography angiography (OCTA). Int J Retina Vitreous. 2015;1:5.PubMedPubMedCentralCrossRefGoogle Scholar
  85. 85.
    Ghasemi Falavarjani K, Al-Sheikh M, Akil H, Sadda SR. Image artefacts in swept-source optical coherence tomography angiography. Br J Ophthalmol. 2017;101(5):564–8.PubMedCrossRefGoogle Scholar
  86. 86.
    Cole ED, Ferrara D, Novais EA, Louzada RN, Waheed NK. Clinical trial endpoints for optical coherence tomography angiography in Neovascular age-related macular degeneration. Retina. 2016;36(Suppl 1):S83–92.PubMedCrossRefGoogle Scholar
  87. 87.
    Ehlers JP, Dupps WJ, Kaiser PK, Goshe J, Singh RP, Petkovsek D, et al. The prospective intraoperative and perioperative ophthalmic ImagiNg with optical CoherEncE TomogRaphy (PIONEER) study: 2-year results. Am J Ophthalmol. 2014;158(5):999–1007.PubMedPubMedCentralCrossRefGoogle Scholar
  88. 88.
    Ray R, Barañano DE, Fortun JA, Schwent BJ, Cribbs BE, Bergstrom CS, et al. Intraoperative microscope-mounted spectral domain optical coherence tomography for evaluation of retinal anatomy during macular surgery. Ophthalmology. 2011;118(11):2212–7.PubMedCrossRefGoogle Scholar
  89. 89.
    Ehlers JP, Srivastava SK, Feiler D, Noonan AI, Rollins AM, Tao YK. Integrative advances for OCT-guided ophthalmic surgery and intraoperative OCT: microscope integration, surgical instrumentation, and heads-up display surgeon feedback. PLoS One. 2014;9(8):e105224.PubMedPubMedCentralCrossRefGoogle Scholar
  90. 90.
    Ehlers JP, Goshe J, Dupps WJ, Kaiser PK, Singh RP, Gans R, et al. Determination of feasibility and utility of microscope-integrated optical coherence tomography during ophthalmic surgery: the DISCOVER study RESCAN results. JAMA Ophthalmol. 2015;133(10):1124–32.PubMedPubMedCentralCrossRefGoogle Scholar
  91. 91.
    Ehlers JP, Uchida A, Srivastava SK. Intraoperative optical coherence tomography-compatible surgical instruments for real-time image-guided ophthalmic surgery. Br J Ophthalmol. 2017;101(10):1306–8.PubMedCrossRefPubMedCentralGoogle Scholar
  92. 92.
    Novotny HR, Alvis DL. A method of photographing fluorescence in circulating blood in the human retina. Circulation. 1961;24:82–6.PubMedCrossRefGoogle Scholar
  93. 93.
    Diabetic retinopathy study. Report Number 6. Design, methods, and baseline results. Report Number 7. A modification of the Airlie House classification of diabetic retinopathy. Prepared by the Diabetic Retinopathy. Invest Ophthalmol Vis Sci. 1981;21(1 Pt 2):1–226.Google Scholar
  94. 94.
    Nagiel A, Lalane RA, Sadda SR, Schwartz SD. Ultra-widefield fundus imaging: a review of clinical applications and future trends. Retina. 2016;36(4):660–78.PubMedCrossRefGoogle Scholar
  95. 95.
    Silva PS, Cavallerano JD, Sun JK, Soliman AZ, Aiello LM, Aiello LP. Peripheral lesions identified by mydriatic ultrawide field imaging: distribution and potential impact on diabetic retinopathy severity. Ophthalmology. 2013;120(12):2587–95.PubMedCrossRefGoogle Scholar
  96. 96.
    Wessel MM, Aaker GD, Parlitsis G, Cho M, D’Amico DJ, Kiss S. Ultra-wide-field angiography improves the detection and classification of diabetic retinopathy. Retina. 2012;32(4):785–91.PubMedCrossRefGoogle Scholar
  97. 97.
    DRCR.net. Peripheral Diabetic Retinopathy (DR) Lesions on Ultrawide-field Fundus Images and Risk of DR Worsening Over Time 2015. http://drcrnet.jaeb.org/Studies.aspx?RecID=239.
  98. 98.
    Singer MA, Tan CS, Surapaneni KR, Sadda SR. Targeted photocoagulation of peripheral ischemia to treat rebound edema. Clin Ophthalmol. 2015;9:337–41.PubMedPubMedCentralCrossRefGoogle Scholar
  99. 99.
    Shoughy SS, Arevalo JF, Kozak I. Update on wide- and ultra-widefield retinal imaging. Indian J Ophthalmol. 2015;63(7):575–81.PubMedPubMedCentralCrossRefGoogle Scholar
  100. 100.
    Abri Aghdam K, Reznicek L, Soltan Sanjari M, Framme C, Bajor A, Klingenstein A, et al. Peripheral retinal non-perfusion and treatment response in branch retinal vein occlusion. Int J Ophthalmol. 2016;9(6):858–62.PubMedPubMedCentralGoogle Scholar
  101. 101.
    Abri Aghdam K, Reznicek L, Soltan Sanjari M, Klingenstein A, Kernt M, Seidensticker F. Anti-VEGF treatment and peripheral retinal nonperfusion in patients with central retinal vein occlusion. Clin Ophthalmol. 2017;11:331–6.PubMedPubMedCentralCrossRefGoogle Scholar
  102. 102.
    Cho M, Kiss S. Detection and monitoring of sickle cell retinopathy using ultra wide-field color photography and fluorescein angiography. Retina. 2011;31(4):738–47.PubMedCrossRefGoogle Scholar
  103. 103.
    Leder HA, Campbell JP, Sepah YJ, Gan T, Dunn JP, Hatef E, et al. Ultra-wide-field retinal imaging in the management of non-infectious retinal vasculitis. J Ophthalmic Inflamm Infect. 2013;3(1):30.PubMedPubMedCentralCrossRefGoogle Scholar
  104. 104.
    Klufas MA, Yannuzzi NA, Pang CE, Srinivas S, Sadda SR, Freund KB, et al. Feasibility and clinical utility of ultra-widefield indocyanine green angiography. Retina. 2015;35(3):508–20.PubMedCrossRefGoogle Scholar
  105. 105.
    Tsui I, Franco-Cardenas V, Hubschman JP, Schwartz SD. Pediatric retinal conditions imaged by ultra wide field fluorescein angiography. Ophthalmic Surg Lasers Imaging Retina. 2013;44(1):59–67.PubMedCrossRefGoogle Scholar
  106. 106.
    Delori FC, Dorey CK, Staurenghi G, Arend O, Goger DG, Weiter JJ. In vivo fluorescence of the ocular fundus exhibits retinal pigment epithelium lipofuscin characteristics. Invest Ophthalmol Vis Sci. 1995;36(3):718–29.PubMedGoogle Scholar
  107. 107.
    Delori FC, Goger DG, Dorey CK. Age-related accumulation and spatial distribution of lipofuscin in RPE of normal subjects. Invest Ophthalmol Vis Sci. 2001;42(8):1855–66.PubMedGoogle Scholar
  108. 108.
    Warrant EJ, Nilsson DE. Absorption of white light in photoreceptors. Vis Res. 1998;38(2):195–207.PubMedCrossRefGoogle Scholar
  109. 109.
    Rudolf M, Vogt SD, Curcio CA, Huisingh C, McGwin G Jr, Wagner A, et al. Histologic basis of variations in retinal pigment epithelium autofluorescence in eyes with geographic atrophy. Ophthalmology. 2013;120(4):821–8.PubMedPubMedCentralCrossRefGoogle Scholar
  110. 110.
    Pilotto E, Benetti E, Convento E, Guidolin F, Longhin E, Parrozzani R, et al. Microperimetry, fundus autofluorescence, and retinal layer changes in progressing geographic atrophy. Can J Ophthalmol. 2013;48(5):386–93.PubMedCrossRefGoogle Scholar
  111. 111.
    Holz FG, Bindewald-Wittich A, Fleckenstein M, Dreyhaupt J, Scholl HP, Schmitz-Valckenberg S, et al. Progression of geographic atrophy and impact of fundus autofluorescence patterns in age-related macular degeneration. Am J Ophthalmol. 2007;143(3):463–72.PubMedCrossRefGoogle Scholar
  112. 112.
    Karadimas P, Paleokastritis GP, Bouzas EA. Fundus autofluorescence imaging findings in retinal pigment epithelial tear. Eur J Ophthalmol. 2006;16(5):767–9.PubMedCrossRefGoogle Scholar
  113. 113.
    Mendis R, Lois N. Fundus autofluorescence in patients with retinal pigment epithelial (RPE) tears: an in-vivo evaluation of RPE resurfacing. Graefes Arch Clin Exp Ophthalmol. 2014;252(7):1059–63.PubMedCrossRefGoogle Scholar
  114. 114.
    Joseph A, Rahimy E, Freund KB, Sorenson JA, Sarraf D. Fundus autofluorescence and photoreceptor bleaching in multiple evanescent white dot syndrome. Ophthalmic Surg Lasers Imaging Retina. 2013;44(6):588–92.PubMedCrossRefGoogle Scholar
  115. 115.
    Marmor MF, Kellner U, Lai TY, Melles RB, Mieler WF. American Academy of O. Recommendations on screening for chloroquine and hydroxychloroquine retinopathy (2016 Revision). Ophthalmology. 2016;123(6):1386–94.PubMedCrossRefGoogle Scholar
  116. 116.
    Greenberg JP, Duncker T, Woods RL, Smith RT, Sparrow JR, Delori FC. Quantitative fundus autofluorescence in healthy eyes. Invest Ophthalmol Vis Sci. 2013;54(8):5684–93.PubMedPubMedCentralCrossRefGoogle Scholar
  117. 117.
    Delori F, Greenberg JP, Woods RL, Fischer J, Duncker T, Sparrow J, et al. Quantitative measurements of autofluorescence with the scanning laser ophthalmoscope. Invest Ophthalmol Vis Sci. 2011;52(13):9379–90.PubMedPubMedCentralCrossRefGoogle Scholar
  118. 118.
    Dubra A, Sulai Y, Norris JL, Cooper RF, Dubis AM, Williams DR, et al. Noninvasive imaging of the human rod photoreceptor mosaic using a confocal adaptive optics scanning ophthalmoscope. Biomed Opt Express. 2011;2(7):1864–76.PubMedPubMedCentralCrossRefGoogle Scholar
  119. 119.
    Roorda A, Zhang Y, Duncan JL. High-resolution in vivo imaging of the RPE mosaic in eyes with retinal disease. Invest Ophthalmol Vis Sci. 2007;48(5):2297–303.PubMedCrossRefGoogle Scholar
  120. 120.
    Bedggood P, Metha A. Direct visualization and characterization of erythrocyte flow in human retinal capillaries. Biomed Opt Express. 2012;3(12):3264–77.PubMedPubMedCentralCrossRefGoogle Scholar
  121. 121.
    Huang G, Gast TJ, Burns SA. In vivo adaptive optics imaging of the temporal raphe and its relationship to the optic disc and fovea in the human retina. Invest Ophthalmol Vis Sci. 2014;55(9):5952–61.PubMedPubMedCentralCrossRefGoogle Scholar
  122. 122.
    Takayama K, Ooto S, Hangai M, Arakawa N, Oshima S, Shibata N, et al. High-resolution imaging of the retinal nerve fiber layer in normal eyes using adaptive optics scanning laser ophthalmoscopy. PLoS One. 2012;7(3):e33158.PubMedPubMedCentralCrossRefGoogle Scholar
  123. 123.
    Ivers KM, Li C, Patel N, Sredar N, Luo X, Queener H, et al. Reproducibility of measuring lamina cribrosa pore geometry in human and nonhuman primates with in vivo adaptive optics imaging. Invest Ophthalmol Vis Sci. 2011;52(8):5473–80.PubMedPubMedCentralCrossRefGoogle Scholar
  124. 124.
    Chui TY, Gast TJ, Burns SA. Imaging of vascular wall fine structure in the human retina using adaptive optics scanning laser ophthalmoscopy. Invest Ophthalmol Vis Sci. 2013;54(10):7115–24.PubMedPubMedCentralCrossRefGoogle Scholar
  125. 125.
    Chui TY, Vannasdale DA, Burns SA. The use of forward scatter to improve retinal vascular imaging with an adaptive optics scanning laser ophthalmoscope. Biomed Opt Express. 2012;3(10):2537–49.PubMedPubMedCentralCrossRefGoogle Scholar
  126. 126.
    Chui TYP, Mo S, Krawitz B, Menon NR, Choudhury N, Gan A, et al. Human retinal microvascular imaging using adaptive optics scanning light ophthalmoscopy. Int J Retina Vitreous. 2016;2:11.PubMedPubMedCentralCrossRefGoogle Scholar
  127. 127.
    Scoles D, Sulai YN, Dubra A. In vivo dark-field imaging of the retinal pigment epithelium cell mosaic. Biomed Opt Express. 2013;4(9):1710–23.PubMedPubMedCentralCrossRefGoogle Scholar
  128. 128.
    Scoles D, Sulai YN, Langlo CS, Fishman GA, Curcio CA, Carroll J, et al. In vivo imaging of human cone photoreceptor inner segments. Invest Ophthalmol Vis Sci. 2014;55(7):4244–51.PubMedPubMedCentralCrossRefGoogle Scholar
  129. 129.
    Liang J, Williams DR, Miller DT. Supernormal vision and high-resolution retinal imaging through adaptive optics. J Opt Soc Am A Opt Image Sci Vis. 1997;14(11):2884–92.PubMedCrossRefGoogle Scholar
  130. 130.
    Sun LW, Johnson RD, Langlo CS, Cooper RF, Razeen MM, Russillo MC, et al. Assessing photoreceptor structure in retinitis Pigmentosa and usher syndrome. Invest Ophthalmol Vis Sci. 2016;57(6):2428–42.PubMedPubMedCentralCrossRefGoogle Scholar
  131. 131.
    Tanna P, Kasilian M, Strauss R, Tee J, Kalitzeos A, Tarima S, et al. Reliability and repeatability of cone density measurements in patients with Stargardt disease and RPGR-associated retinopathy. Invest Ophthalmol Vis Sci. 2017;58(9):3608–15.PubMedPubMedCentralCrossRefGoogle Scholar
  132. 132.
    Bessho K, Fujikado T, Mihashi T, Yamaguchi T, Nakazawa N, Tano Y. Photoreceptor images of normal eyes and of eyes with macular dystrophy obtained in vivo with an adaptive optics fundus camera. Jpn J Ophthalmol. 2008;52(5):380–5.PubMedCrossRefGoogle Scholar
  133. 133.
    Kitaguchi Y, Kusaka S, Yamaguchi T, Mihashi T, Fujikado T. Detection of photoreceptor disruption by adaptive optics fundus imaging and Fourier-domain optical coherence tomography in eyes with occult macular dystrophy. Clin Ophthalmol. 2011;5:345–51.PubMedPubMedCentralCrossRefGoogle Scholar
  134. 134.
    Flatter JA, Cooper RF, Dubow MJ, Pinhas A, Singh RS, Kapur R, et al. Outer retinal structure after closed-globe blunt ocular trauma. Retina. 2014;34(10):2133–46.PubMedPubMedCentralCrossRefGoogle Scholar
  135. 135.
    Stepien KE, Han DP, Schell J, Godara P, Rha J, Carroll J. Spectral-domain optical coherence tomography and adaptive optics may detect hydroxychloroquine retinal toxicity before symptomatic vision loss. Trans Am Ophthalmol Soc. 2009;107:28–33.PubMedPubMedCentralGoogle Scholar
  136. 136.
    Ooto S, Hangai M, Takayama K, Sakamoto A, Tsujikawa A, Oshima S, et al. High-resolution imaging of the photoreceptor layer in epiretinal membrane using adaptive optics scanning laser ophthalmoscopy. Ophthalmology. 2011;118(5):873–81.PubMedCrossRefGoogle Scholar
  137. 137.
    Ooto S, Hangai M, Takayama K, Ueda-Arakawa N, Hanebuchi M, Yoshimura N. Photoreceptor damage and foveal sensitivity in surgically closed macular holes: an adaptive optics scanning laser ophthalmoscopy study. Am J Ophthalmol. 2012;154(1):174–86. e2.PubMedCrossRefGoogle Scholar
  138. 138.
    Yokota S, Ooto S, Hangai M, Takayama K, Ueda-Arakawa N, Yoshihara Y, et al. Objective assessment of foveal cone loss ratio in surgically closed macular holes using adaptive optics scanning laser ophthalmoscopy. PLoS One. 2013;8(5):e63786.PubMedPubMedCentralCrossRefGoogle Scholar
  139. 139.
    Stepien KE, Martinez WM, Dubis AM, Cooper RF, Dubra A, Carroll J. Subclinical photoreceptor disruption in response to severe head trauma. Arch Ophthalmol. 2012;130(3):400–2.PubMedPubMedCentralCrossRefGoogle Scholar
  140. 140.
    Pinhas A, Dubow M, Shah N, Chui TY, Scoles D, Sulai YN, et al. In vivo imaging of human retinal microvasculature using adaptive optics scanning light ophthalmoscope fluorescein angiography. Biomed Opt Express. 2013;4(8):1305–17.PubMedPubMedCentralCrossRefGoogle Scholar
  141. 141.
    Dubow M, Pinhas A, Shah N, Cooper RF, Gan A, Gentile RC, et al. Classification of human retinal microaneurysms using adaptive optics scanning light ophthalmoscope fluorescein angiography. Invest Ophthalmol Vis Sci. 2014;55(3):1299–309.PubMedPubMedCentralCrossRefGoogle Scholar
  142. 142.
    Pinhas A, Dubow M, Shah N, Cheang E, Liu CL, Razeen M, et al. Fellow eye changes in patients with nonischemic central retinal vein occlusion: assessment of perfused foveal microvascular density and identification of nonperfused capillaries. Retina. 2015;35(10):2028–36.PubMedPubMedCentralCrossRefGoogle Scholar
  143. 143.
    Choudhury NM, Menon N, Gan A, Razeen MM, Pinhas A, Shah N, et al. In vivo imaging of human retinal microvasculature in sickle cell retinopathy using adaptive optics scanning light ophthalmoscope fluorescein angiography and offset pinhole imaging. Invest Ophthalmol Vis Sci. 2015;56:E-abstract 5949.Google Scholar
  144. 144.
    Chui TY, Pinhas A, Gan A, Razeen M, Shah N, Cheang E, et al. Longitudinal imaging of microvascular remodelling in proliferative diabetic retinopathy using adaptive optics scanning light ophthalmoscopy. Ophthalmic Physiol Opt. 2016;36(3):290–302.PubMedPubMedCentralCrossRefGoogle Scholar

Copyright information

© Springer Nature Singapore Pte Ltd. 2018

Authors and Affiliations

  • Alexander Barash
    • 1
  • Richard I. Kaplan
    • 1
  • Meenakashi Gupta
    • 1
  1. 1.New York Eye and Ear Infirmary of Mount SinaiNew YorkUSA

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