Preparation, Characterization and Optimization of Cinnamon-Loaded PLGA Nanoparticles
Cinnamon act as potential drug for lot of curable diseases such as Diabetes. For increasing its bioavailability as a drug, Nano encapsulation of cinnamon powder was carried out using solvent evaporation method. The effect of organic solvent and surfactant such as PVA(Polyvinylalcohol) and Pluronic F-68 was studied. The morphology and particle size of nanoparticles was studied using Scanning Electron Microscope (SEM). Drug release study for cinnamon and corresponding nanoparticles was also done. Results show that different surfactants have different impact on nanoparticles size and morphology. Nanoparticles obtained were in size range of 100–250 nm. The study reveals that cinnamon loaded PLGA nanoparticles has potential therapeutic efficiency and may be used in treatment of type II Diabetes.
KeywordsBioavailability Nanoparticles Surfactants Drug Cinnamon PLGA PVA Pluronic-68
Authors would like to extend their thanks to Dr. Rakesh Sharma from Delhi University for providing the IR facility and also to Dr. V. V. Ramamurthy from Indian Agricultural Research Institute, New Delhi for providing the SEM facility for their sample study.