Recent Progress in the Chemistry of Tri-substituted Triazole via [3 + 2] Cycloaddition of Azide and Double Bond: An Overview

  • Rajesh Kumar
  • Manish Kumar
  • Vipin K. Maikhuri
  • Navneet Manav
  • Ashok K. Prasad
  • Divya Mathur
Conference paper


Triazoles belong to a class of nitrogen containing compounds which are known for its highly valuable and versatile biological activities. More than 50 years ago, the first synthesis of tri-substituted triazoles was achieved by Huisgen via azide-alkyne cycloaddition. Over the years the remarkable achievement in triazole-based pharmacology promoted ample interest in the discovery of new synthetic methods and catalysts for the synthesis of this miraculous scaffold. Recent tri-substituted triazoles development based on various azides and double bonds have been summarized in this report.


Catalyst Cycloaddition Regioselective Tri-substituted triazoles 



The authors thank University of Delhi for providing financial support under DU-DST purse grant.


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Copyright information

© Springer Nature Singapore Pte Ltd. 2018

Authors and Affiliations

  • Rajesh Kumar
    • 1
  • Manish Kumar
    • 1
  • Vipin K. Maikhuri
    • 1
  • Navneet Manav
    • 2
  • Ashok K. Prasad
    • 1
  • Divya Mathur
    • 3
  1. 1.Bioorganic Laboratory, Department of ChemistryUniversity of DelhiNew DelhiIndia
  2. 2.Dyal Singh CollegeUniversity of DelhiNew DelhiIndia
  3. 3.Daulat Ram CollegeUniversity of DelhiDelhiIndia

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