Biotechnological Strategies for Improvement of Withania somnifera (L.) Dunal

  • Kulwinder Kaur
  • Ashok Kumar Panigrahi
  • Pratap Kumar Pati


Withania somnifera (L.) Dunal is one of the most reputed medicinal plants belonging to the family Solanaceae. The plant contains various steroidal lactones, alkaloids, polyphenols, flavanol glycosides, and sterols, which are responsible for its medicinal properties such as antitumor, neuroprotective, cardioprotective, antiaging, and anti-inflammatory. The main focus of research in W. somnifera is to increase the production of withanolides, the pharmaceutically important constituents. Various in vitro strategies like organ and cell culture and genetic manipulation and molecular biology tools such as metabolic engineering have been adapted to enhance secondary metabolite production. The present chapter provides a brief overview of challenges in W. somnifera and discusses some of the latest developments to address these challenges.


Secondary metabolites Genetic transformation In vitro propagation Withanolide Withania somnifera 



2,4-Dichlorophenoxyacetic acid




Indole-3-acetic acid


Indole-3-butyric acid




Methyl jasmonate


1-Naphthalene acetic acid


Plant growth regulators


Salicylic acid


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Copyright information

© Springer Nature Singapore Pte Ltd. 2018

Authors and Affiliations

  • Kulwinder Kaur
    • 1
  • Ashok Kumar Panigrahi
    • 2
  • Pratap Kumar Pati
    • 1
  1. 1.Department of BiotechnolgyGuru Nanak Dev UniversityAmritsarIndia
  2. 2.Department of PharmacologyVeer Surendra Sai Institute of Medical Sciences and ResearchBurla, SambalpurIndia

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