CircRNAs occur in the posttranscriptional shear process, and single-stranded RNA molecules form a ring through covalent bonding. The advances in high-throughput sequencing technology have fully explored noncoding linear RNA (NCL), which has made NCL reenter the researchers’ field of view, especially cirRNAs. Annular RNA has been shown to be rich, highly expressive, and evolutionarily conservative. Some annular RNAs have been shown to affect miRNA regulation of genes and can be used as miRNA sponges, and possibly has the effect of transcriptional regulation, translation, and other functions for parent genes. It also plays an important regulatory role in some diseases, for example, Alzheimer’s disease, diabetes, ischemic heart disease, and some cancers, it can halt the progress of disease, and can be used as a biological marker for disease detection. In this chapter, the formation mechanism, function, detection method, identification of novel circRNAs, and the correlation of diseases are summarized, and future research was reviewed.
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