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Toxicological and Pharmacological Use of Anticancer Compounds

  • Charles Gnanaraj
  • Sivapragasam Gothai
  • Katyakyini Muniandy
  • Rengarajan Thamaraiselvan
  • Palanisamy Arulselvan
Chapter

Abstract

Knowledge of medicinal plants from traditional medicinal drug therapy has brought limitless implications towards the discovery of novel compounds for modern therapeutic applications particularly for anticancer research. Research approaches have been taken for the development of traditional medicinal products into effective, non-toxic and clinically proven pharmaceuticals. Plant-derived anticancer compounds might exert adverse toxic effects in humans, depending on the species of plant, drug administration route, dose regimens and drug receptiveness. Due to this possibility, it is important to assess the toxicity profiles of new potential anticancer compounds through proper toxicological tests. The importance of preclinical toxicology studies is continually drifting from the use of conventional methods to assess the impending adverse effects of new anticancer agents over the past 10 years. Recent practice encompasses designing and carrying out more personalized agent-directed research within the framework of clinical pharmacology guidelines. Distinctive standpoints have been brought into view by clinical application of anticancer drugs that are apparent in their discovery and development. Evolving standards in estimating novel drug candidates through clinical and preclinical trials manifest the cytotoxic compound enhancements over time, with substantial aid from circumstances, and the current interest in discovering drug candidates with specifications on reaching targeted cells. This chapter highlights the relevance of plant-derived anticancer compounds through their pharmacological and toxicological uses.

Keywords

Anticancer compounds Clinical pharmacology Drug discovery Toxicity Polyphenols 

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Copyright information

© Springer Nature Singapore Pte Ltd. 2017

Authors and Affiliations

  • Charles Gnanaraj
    • 1
    • 2
  • Sivapragasam Gothai
    • 3
  • Katyakyini Muniandy
    • 3
  • Rengarajan Thamaraiselvan
    • 2
  • Palanisamy Arulselvan
    • 3
    • 4
  1. 1.Biotechnology Research InstituteUniversiti Malaysia Sabah, Jalan UMSKota KinabaluMalaysia
  2. 2.Scigen Research and Innovation, Periyar Technology Business IncubatorThanjavurIndia
  3. 3.Laboratory of Vaccines and Immunotherapeutics, Institute of BioscienceUniversiti Putra MalaysiaSerdangMalaysia
  4. 4.Muthayammal Centre for Advanced Research, Muthayammal College of Arts and ScienceRasipuram, NamakkalIndia

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