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Signaling Pathways of Anticancer Plants: Action and Reaction

  • Bilal Ahmad
  • Mohd Irfan Naikoo
  • Hassan Jaleel
  • Asfia Shabbir
  • Farha Rehman
  • Yawar Sadiq
  • M. Masroor Akhtar Khan
Chapter

Abstract

Insights into the alterations of the mammalian genome in neoplastic diseases and the mechanism of action of the therapeutic anticancer drugs are one of the extremely important, diverse, and challenging areas of study currently. By the virtue of lingering toxicity of the reputable chemical drugs, plant-derived anticancer substances, viz., vinblastine, vincristine, Taxol, topotecan, camptothecin, and podophyllotoxin derivatives, are highly safe and efficient in the treatment and management of this monstrous disease. Among the list of accessible targets of the therapeutic drugs, DNA replication and mitosis, hormonal regulation of cell growth, aberrant signaling pathways, cell surface receptors, and second messengers are noteworthy. Nowadays, newer therapeutic approaches are being followed, and an increased understanding into the mechanism of action of the therapeutic anticancer agents is evolving due to continuous and relentless efforts of the researchers. The aim of the present chapter is to highlight the application of medicinal plants and their secondary metabolites as anticancer substances and also focus on the signaling aspects of potential anticancer compounds to find out their mechanisms of action against cancer cells.

Keywords

Cancer cell DNA methylation Epigenetic factors Secondary metabolites Therapeutic potential 

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Copyright information

© Springer Nature Singapore Pte Ltd. 2017

Authors and Affiliations

  • Bilal Ahmad
    • 1
  • Mohd Irfan Naikoo
    • 1
  • Hassan Jaleel
    • 1
  • Asfia Shabbir
    • 1
  • Farha Rehman
    • 2
  • Yawar Sadiq
    • 1
  • M. Masroor Akhtar Khan
    • 1
  1. 1.Department of BotanyAligarh Muslim UniversityAligarhIndia
  2. 2.Department of BotanyMohammad Ali Jauhar UniversityRampurIndia

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